Review
Biochemistry & Molecular Biology
Katarzyna Piotrowska, Katarzyna Zgutka, Marta Tkacz, Maciej Tarnowski
Summary: Diabetes is a major healthcare problem, especially for pregnant women, and requires an appropriate approach. Gestational diabetes mellitus and type 2 diabetes mellitus share many similarities and induce oxidative stress and cellular stress signaling. The risk of diabetes during pregnancy can lead to complications for both the mother and fetus. Physical activity is not only important for treating the negative effects of diabetes, but also for preventing its progression and reversing changes. Regular training sessions have a positive effect on the immune status of diabetic patients, mothers, and fetuses, causing changes in immune cell levels, cytokine activation, production and secretion, as well as microRNA, which improve overall well-being.
Article
Biochemistry & Molecular Biology
Monisha Prasad, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan, Praveen Kumar Kumar, Shanmughavel Piramanayagam, Leelavinothan Pari
Summary: The study found that diosgenin reduces dyslipidemia, hypertension, and pro-inflammatory cytokines in the aorta of diabetic rats by regulating the iRhom2/TACE signaling pathway. Molecular docking analysis confirmed the potential binding interaction of diosgenin with key signaling molecules. The results indicate that diosgenin can attenuate ER stress-induced inflammation in diabetic rat aorta.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Xueqiong Yao, Rui Liu, Xiu Li, Yan Li, Zhen Zhang, Shanshan Huang, Yanyan Ge, Xiuzhi Chen, Xuefeng Yang
Summary: The combination supplementation of zinc, selenium, and chromium significantly alleviated glucose intolerance and oxidative stress induced by GDM, and inhibited the activation of hepatic ER stress, contributing to the promotion of insulin signaling and maintenance of glucose homeostasis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Renata Saucedo, Clara Ortega-Camarillo, Aldo Ferreira-Hermosillo, Mary Flor Diaz-Velazquez, Claudia Meixueiro-Calderon, Jorge Valencia-Ortega
Summary: Gestational diabetes mellitus (GDM) is a common pregnancy complication related to oxidative stress and inflammation. This review evaluates the mechanisms through which oxidative stress and inflammation contribute to the development of GDM. Additionally, it discusses therapies that can modulate oxidative stress and inflammation.
Article
Developmental Biology
Mengzhou He, Xijiao Guo, Jing Jia, Jingyi Zhang, Xuan Zhou, Lijie Wei, Jun Yu, Shaoshuai Wang, Ling Feng
Summary: This study investigates the role of endoplasmic reticulum stress (ERS) and peroxisome proliferator-activated receptor a (PPARa) in the development of gestational diabetes mellitus (GDM) and their relationship in regulating inflammation. The results show that ERS is elevated in GDM placentas, leading to increased secretion of IL-6 and TNF-a and reduced expression of GLUT-4. PPARa is diminished in GDM placentas and inhibits inflammatory responses through the NF-κB nuclear-transport process.
Article
Biochemistry & Molecular Biology
Rebeca Melero, Maria Elena Quiroz-Rodriguez, Francisco Lara-Hernandez, Josep Redon, Guillermo Saez, Laisa S. Briongos-Figuero, Jessica Abadia-Otero, Juan Carlos Martin-Escudero, F. Javier Chaves, Guillermo Ayala, Ana-Barbara Garcia-Garcia
Summary: This study found a significant association between genetic polymorphisms related to oxidative stress parameters and the risk of developing Type 2 Diabetes Mellitus in a general population from Spain, indicating the important role of genetic variations and their interaction with oxidative stress parameters in the risk of developing T2D.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Ling Chen, Penghui Nie, LiYang Yao, YiZhou Tang, Wuding Hong, Wenting Liu, Fen Fu, Hengyi Xu
Summary: This study found that TiO2 nanoparticles have adverse effects on mice with gestational diabetes mellitus, potentially triggering oxidative stress and activating the ER stress pathway to induce cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Xue Li, Mingming Zhen, Chen Zhou, Meilan Yu, Lei Liu, Chunying Shu, Chunru Wang
Summary: This study investigates the use of hydroxylated [70] fullerene nanoparticles (HFNPs) as antioxidants to reverse insulin resistance in diabetes. The study shows that HFNPs can alleviate insulin resistance by regulating oxidative stress and endoplasmic reticulum stress, resulting in improved glucose uptake and reduced blood glucose levels. Furthermore, HFNPs inhibit the activation of phosphorylated c-Jun N-terminal kinase (JNK), reactivating the insulin receptor substrate (IRS) signaling pathway and inhibiting gluconeogenesis. Importantly, HFNPs exhibit no severe toxicity to main tissues. This research contributes to the understanding of the role of antioxidants in regulating insulin resistance and provides new perspectives for the treatment of insulin resistance-related diseases.
Article
Biochemistry & Molecular Biology
Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang
Summary: JAT has vasoprotective effects in diabetes and obesity by enhancing the Akt/eNOS pathway and NO bioavailability, as well as suppressing ER stress and oxidative stress to improve endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Li Ji, Huan Gu
Summary: The study showed that rhein has inhibitory effects on weight, inflammatory factors, and oxidative stress, and improves insulin resistance, blood lipid levels, and pathological injury. Moreover, rhein also affects ERs in peripheral blood and adipose tissue, significantly reducing cell apoptosis levels. Additionally, rhein treatment decreases adipogenic differentiation and increases p62 expression, while impacting PPAR gamma and INSR levels.
Article
Cell Biology
Subramani Yuvaraj, Arumugam Kalaiselvi Ajeeth, Shanavas Syed Mohamed Puhari, Albert Abhishek, Tharmarajan Ramprasath, Varadaraj Vasudevan, Narasimman Vignesh, Govindan Sadasivam Selvam
Summary: This study reveals that chrysin attenuates ER stress and shows a cardioprotective effect through the activation of the Nrf2 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Hongri Wang, Xuzheng Chen, Xueqin Miao, Kunbin Lu, Mengjuan He, Xiaomei Wu
Summary: Dendrobium mixture (DMix) improved gestational diabetes mellitus (GDM) by inhibiting oxidative condition, inflammation factors, hyperglycemia, and hyperlipidemia. This research provides a new approach for the prevention and treatment of GDM.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Liping Cao, Jinliang Du, Zhijuan Nie, Rui Jia, Guojun Yin, Pao Xu, Weidong Ding, Gangchun Xu
Summary: This study investigated the mechanism of CTX-induced liver injury in tilapia by studying the changes in endoplasmic reticulum stress, inflammation, and antioxidant status. The results showed that CTX administration caused cytotoxicity on hepatocytes, increased liver index, and histological lesions. CTX also decreased antioxidant ability, up-regulated inflammatory response-related genes, and promoted ERS-related gene expression. Furthermore, CTX injection down-regulated gene expressions related to antioxidative status. Overall, these findings suggest that CTX injection induces liver damage through cytotoxicity, reduced antioxidant capacity, inflammation, and endoplasmic reticulum stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Zhou, Chunxiu Zhou, Xutao Zhang, Chi Teng Vong, Yitao Wang, Wai San Cheang
Summary: The study showed that coptisine can improve vascular function in diabetic patients by suppressing ER stress and oxidative stress, enhancing endothelium-dependent relaxation, indicating the therapeutic potential of coptisine for treating diabetic vasculopathy.
Article
Pharmacology & Pharmacy
Krishna M. Prasad, Sundhar Mohandas, Kunka Mohanram Ramkumar
Summary: Endoplasmic reticulum stress plays a key role in the development of metabolic diseases like diabetes. The unfolded protein response signaling pathways are dysregulated in diabetes and contribute to the complications associated with the disease. Factors like hyperglycemia, oxidative stress, disrupted calcium homeostasis, and inflammation activate signaling pathways that overwhelm the endoplasmic reticulum's ability to restore homeostasis, leading to cell apoptosis. Understanding these signaling pathways has revealed potential therapeutic targets in the form of ER stress inhibitors, which have shown promise in alleviating ER stress in diabetes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)