Article
Nutrition & Dietetics
Gehua Zhu, Jiamin Xu, Guanghua Guo, Feng Zhu
Summary: This study used the two-sample Mendelian randomization (MR) approach to assess the causal relationship between lipids, apolipoproteins, and telomere length (TL). The results suggest potential positive causal relationships between genetically predicted MUFA, MUFA/FA ratio, LDL-C, VLDL-C, total cholesterol, ApoB, and TG with TL.
Article
Clinical Neurology
Tianyu Jin, Wei Huang, Fangzheng Cao, Xinyue Yu, Zhenhua Ying, Shunyuan Guo, Yifan Cheng, Chao Xu
Summary: This study used Mendelian randomization to assess the causal relationship between circulating adiponectin and Alzheimer's disease risk. The findings suggest that there is no significant causal association between circulating adiponectin and Alzheimer's disease risk.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Qiao Liao, Jian He, Fa-Fa Tian, Fang-Fang Bi, Kun Huang
Summary: The study suggests a potential causal effect of leukocyte telomere length (LTL) on the risk of multiple sclerosis (MS). Genetically predicted shorter LTL could increase the risk of MS in the European population. LTL should be noted and emphasized in the pathogenesis and treatment of MS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Dan He, Peilin Meng, Chun'e Li, Yumeng Jia, Yan Wen, Chuyu Pan, Zhen Zhang, Jingxi Zhang, Huijie Zhang, Yujing Chen, Yijing Zhao, Xiaoyue Qin, Qingqing Cai, Wenming Wei, Sirong Shi, Xiaoge Chu, Na Zhang, Feng Zhang
Summary: This study aimed to investigate the association and causal relationship between sleep and telomere length (TL). Using genome-wide association study (GWAS) datasets and mendelian randomization (MR) analysis, the study found no evidence for causal association between insomnia and TL in individuals of European ancestry, but identified a candidate gene associated with both insomnia and TL.
Article
Immunology
Jun Zhang
Summary: This study used Mendelian randomization (MR) analysis and found a negative association between telomere length (TL) and the risk of juvenile idiopathic arthritis (JIA), but no association with JIA-associated iridocyclitis. These results were validated in a European population and larger studies are needed to further understand the role of TL in these diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jodie Lord, Bradley Jermy, Rebecca Green, Andrew Wong, Jin Xu, Cristina Legido-Quigley, Richard Dobson, Marcus Richards, Petroula Proitsi
Summary: This study explored the causal relationship between metabolites associated with midlife cognition and AD, highlighting XL.HDL.FC, total lipids, phospholipids, and XL.HDL particle concentration as potential causal candidates. Evidence suggests that GP may also play a role in AD pathology and warrants further investigation. Understanding these relationships could inform risk reduction strategies for AD, which is believed to develop decades before symptoms appear.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Jiaxin Hu, Jukun Song, Zhu Chen, Jing Yang, Qianhui Shi, Fuqian Jin, Qiyuan Pang, Xingtao Chang, Yuan Tian, Yi Luo, Liming Chen
Summary: This study investigated the causal relationship between periodontitis and shortened telomere lengths (TL) using a two-sample Mendel randomized (MR) study. The results showed that a genetic prediction of short TL was causally associated with a higher risk of periodontitis, while periodontitis had no significant effect on TL. No pleiotropy was detected in sensitivity analysis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The research indicates a causal relationship between telomere attrition and kidney function impairment. Genetic predisposition towards telomere attrition is associated with a higher risk of chronic kidney disease, while a genetically predicted kidney function decrease is linked to an increase in telomere attrition.
KIDNEY INTERNATIONAL
(2021)
Article
Virology
Danqi Huang, Siqi Lin, Junting He, Qi Wang, Yiqiang Zhan
Summary: Using a bidirectional Mendelian randomization study, no evidence was found to support a causal association between COVID-19 and leukocyte telomere length (LTL).
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Ancha Baranova, Hongbao Cao, Fuquan Zhang
Summary: Genetic correlation and Mendelian randomization analyses showed that severe COVID-19 may contribute to the development of Alzheimer's disease, while mild cases of COVID-19 do not increase the risk. The influence of COVID-19 on Alzheimer's disease may be mediated by immunity-related pathways acting predominantly in the lung and brain.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Geriatrics & Gerontology
Wenxiu Wang, Ninghao Huang, Zhenhuang Zhuang, Zimin Song, Yueying Li, Xue Dong, Wendi Xiao, Yimin Zhao, Jinzhu Jia, Zhonghua Liu, Lu Qi, Tao Huang
Summary: Telomere length has been found to be associated with various health outcomes. Through a large-scale Mendelian randomization study, it is suggested that genetically determined telomere length might have causal effects on respiratory diseases, digestive diseases, myocardial infarction, neoplasms, diseases of the genitourinary system, and essential hypertension.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Blanca Rodriguez-Fernandez, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sanchez-Benavides, Marc Suarez-Calvet, Gregory Operto, Carolina Minguillon, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Pineyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, Jose Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila, Marta Crous-Bou
Summary: This study used Mendelian randomization analysis to explore the potential causal role of telomere length (TL) in Alzheimer's disease (AD) endophenotypes. The results showed that longer TL was associated with lower levels of CSF A beta and higher levels of CSF NfL in APOE-epsilon 4 non-carriers. Additionally, longer TL was associated with greater cortical thickness in age and AD-related brain signatures and lower levels of CSF p-tau among individuals at high genetic predisposition to AD.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Inmaculada Rodriguez-Martin, Gonzalo Villanueva-Martin, Alfredo Guillen-Del-Castillo, Norberto Ortego-Centeno, Jose L. Callejas, Carmen P. Simeon-Aznar, Javier Martin, Marialbert Acosta-Herrera
Summary: By using the two-sample Mendelian randomization approach, this study reveals a causal relationship between telomere length in leukocytes and systemic sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jackson G. Thorp, Brittany L. Mitchell, Zachary F. Gerring, Jue-Sheng Ong, Puya Gharahkhani, Eske M. Derks, Michelle K. Lupton
Summary: Alzheimer's disease (AD) is projected to affect 132 million people by 2050. This study investigates whether previously speculated AD risk factors are causally associated with AD susceptibility using large-scale genetic data. The findings suggest that only the cognitive component of educational attainment (intelligence) is independently causally linked to AD.
NEUROBIOLOGY OF AGING
(2022)
Article
Immunology
Meijie Ye, Yu Wang, Yiqiang Zhan
Summary: This study used the two-sample Mendelian randomization design to investigate the causal effect of leukocyte telomere length (TL) on the risk of Graves' disease. The results showed that genetically predicted longer leukocyte TL was associated with a lower risk of Graves' disease. Further studies are needed to explore the underlying mechanism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Nasim Mavaddat, Lorenzo Ficorella, Tim Carver, Andrew Lee, Alex P. Cunningham, Michael Lush, Joe Dennis, Marc Tischkowitz, Kate Downes, Donglei Hu, Eric Hahnen, Rita K. Schmutzler, Tracy L. Stockley, Gregory S. Downs, Tong Zhang, Anna M. Chiarelli, Stig E. Bojesen, Cong Liu, Wendy K. Chung, Monica Pardo, Lidia Feliubadalo, Judith Balmana, Jacques Simard, Antonis C. Antoniou, Douglas F. Easton
Summary: BOADICEA model can identify women at higher or lower risk of developing breast cancer by incorporating PRS. Different variations of the PRS were evaluated, and logistic regression and retrospective likelihood approaches were used to estimate the parameters. The study showed that BOADICEA can be adapted to different PRS, providing a comprehensive breast cancer risk assessment.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Critical Care Medicine
Sune Moeller Skov-Jeppesen, Camilla Jannie Kobylecki, Katja Kemp Jacobsen, Stig Egil Bojesen
Summary: This study investigated the relationship between AHRR gene methylation and smoking behaviors and demographic variables. The research found that AHRR gene methylation could recover after quitting smoking, and the recovery was more pronounced and faster in younger individuals.
Article
Oncology
Josephine M. N. L. Cardozo, Irene L. E. Andrulis, Stig E. Bojesen, Thilo M. Doerk, Diana M. A. Eccles, Peter A. J. Fasching, Maartje J. Hooning, Renske Keeman, Heli Nevanlinna, Emiel J. T. F. Rutgers, Douglas F. Easton, Per Hall, Paul D. P. J. Pharoah, Laura J. K. van't Veer, Marjanka K. Schmidt
Summary: A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS313) is associated with risk of breast cancer and contralateral breast cancer. This study aimed to evaluate the association of the PRS313 with clinicopathologic characteristics of, and survival following, breast cancer. The results showed that PRS313 is associated with favorable tumor characteristics but not independently associated with prognosis. Rating: 8/10.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Ophthalmology
Katrine L. L. Rasmussen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard, Ruth Frikke-Schmidt
Summary: This study aims to determine the association between genetic variations in the apolipoprotein E (APOE) gene and the risk of age-related macular degeneration (AMD). The results suggest that structural variations in the APOE gene may be important for the risk of AMD in individuals of European ancestry.
JAMA OPHTHALMOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Medical Laboratory Technology
Jesper Qvist Thomassen, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: This study found that high plasma concentrations of calcium ions were associated with increased risk of Alzheimer's disease (AD), but no genetic associations were found. This suggests that the observational findings may be due to reverse causation or residual confounding.
CLINICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Benjamin N. Wadstrom, Kasper M. Pedersen, Anders B. Wulff, Borge G. Nordestgaard
Summary: The purpose of this review is to compare the evidence for inflammation and low-density lipoprotein (LDL) cholesterol in atherosclerotic cardiovascular disease (ASCVD). Recent findings suggest that IL-6 mediated inflammation may cause ASCVD along with LDL cholesterol. Future research should focus on improving anti-inflammatory therapy and implementing more effective LDL cholesterol lowering therapy.
CURRENT OPINION IN LIPIDOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Caroline A. Koch, Emilie W. Kjeldsen, Ruth Frikke-Schmidt
Summary: Due to the increasing environmental focus, plant-based diets are gaining popularity. A systematic review and meta-analysis were conducted to examine the effect of vegetarian and vegan diets on blood lipid levels. The results showed that plant-based diets can reduce total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B levels.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Ida Juul Rasmussen, Ruth Frikke-Schmidt
Summary: Dementia is a major global challenge, but 40% of cases can be prevented. Prevention measures, such as reducing cardiovascular risk factors, are crucial for reducing the incidence of dementia. Genome-wide association studies can be useful for identifying novel pathogenic pathways and high-risk individuals.
EUROPEAN HEART JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Shoaib Afzal, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: Genetic variants in ABCA1 associated with high HDL cholesterol concentrations are also associated with higher risk of AMD, suggesting a role for ABCA1 in AMD pathogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu-Yu Chen, Juncheng Dai, Rayjean J. Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Maria Teresa Landi, Dongxin Lin, Wei Zheng, Zhihua Yin, Baosen Zhou, Bao Song, Jiucun Wang, Wei Jie Seow, Lei Song, I-Shou Chang, Wei Hu, Li-Hsin Chien, Qiuyin Cai, Yun-Chul Hong, Hee Nam Kim, Yi-Long Wu, Maria Pik Wong, Brian Douglas Richardson, Karen M. Funderburk, Shilan Li, Tongwu Zhang, Charles Breeze, Zhaoming Wang, Batel Blechter, Bryan A. Bassig, Jin Hee Kim, Demetrius Albanes, Jason Y. Y. Wong, Min-Ho Shin, Lap Ping Chung, Yang Yang, She-Juan An, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young-Chul Kim, Neil E. Caporaso, Jiang Chang, James Chung Man Ho, Michiaki Kubo, Yataro Daigo, Minsun Song, Yukihide Momozawa, Yoichiro Kamatani, Masashi Kobayashi, Kenichi Okubo, Takayuki Honda, Dean H. Hosgood, Hideo Kunitoh, Harsh Patel, Shun-ichi Watanabe, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Hidehito Horinouchi, Masahiro Tsuboi, Ryuji Hamamoto, Koichi Goto, Yuichiro Ohe, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Megumi Hara, Yuichiro Nishida, Kenji Takeuchi, Kenji Wakai, Koichi Matsuda, Yoshinori Murakami, Kimihiro Shimizu, Hiroyuki Suzuki, Motonobu Saito, Yoichi Ohtaki, Kazumi Tanaka, Tangchun Wu, Fusheng Wei, Hongji Dai, Mitchell J. Machiela, Jian Su, Yeul Hong Kim, In-Jae Oh, Victor Ho Fun Lee, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Adeline Seow, Jae Yong Park, Sun-Seog Kweon, Kun-Chieh Chen, Yu-Tang Gao, Biyun Qian, Chen Wu, Daru Lu, Jianjun Liu, Ann G. Schwartz, Richard Houlston, Margaret R. Spitz, Ivan P. Gorlov, Xifeng Wu, Ping Yang, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeboeller, Bu-Tian Ji, H-Erich Wichmann, David C. Christiani, Gadi Rennert, Susanne Arnold, Paul Brennan, James McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Kjell Grankvist, Mikael Johansson, Angela Cox, Fiona Taylor, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Hyo-Sung Jeon, Shih Sheng Jiang, Jae Sook Sung, Chung-Hsing Chen, Chin-Fu Hsiao, Yoo Jin Jung, Huan Guo, Zhibin Hu, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Belynda Hicks, Jia Liu, Bin Zhu, Sonja I. Berndt, Wei Wu, Junwen Wang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, Chang Hyun Kang, Wen-Chang Wang, Jun Xu, Peng Guan, Wen Tan, Chong-Jen Yu, Gong Yang, Alan Dart Loon Sihoe, Ying Chen, Yi Young Choi, Jun Suk Kim, Ho-Il Yoon, In Kyu Park, Ping Xu, Qincheng He, Chih-Liang Wang, Hsiao-Han Hung, Roel C. H. Vermeulen, Iona Cheng, Junjie Wu, Wei-Yen Lim, Fang-Yu Tsai, John K. C. Chan, Jihua Li, Hongyan Chen, Hsien-Chih Lin, Li Jin, Jie Liu, Norie Sawada, Taiki Yamaji, Kathleen Wyatt, Shengchao A. Li, Hongxia Ma, Meng Zhu, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ann Chao, Motoki Iwasaki, Junjie Zhu, Gening Jiang, Ke Fei, Guoping Wu, Chih-Yi Chen, Chien-Jen Chen, Pan-Chyr Yang, Jinming Yu, Victoria L. Stevens, Joseph F. Fraumeni, Nilanjan Chatterjee, Olga Y. Gorlova, Chao Agnes Hsiung, Christopher I. Amos, Hongbing Shen, Stephen J. Chanock, Nathaniel Rothman, Takashi Kohno, Qing Lan
Summary: This study identified 12 novel susceptibility variants for lung adenocarcinoma and a total of 28 loci associated with the disease in East Asian populations. Additionally, new candidate genes were discovered, contributing to the understanding of the disease etiology. These findings have important implications for the research and translational applications of lung adenocarcinoma in individuals from East Asian populations.
NATURE COMMUNICATIONS
(2023)
Review
Peripheral Vascular Disease
Takahito Doi, Anne Langsted, Borge G. Nordestgaard
Summary: East Asia has a significant population and ischemic heart disease is a major cause of death in this region. However, the evidence on lipoproteins and lipoprotein cholesterol with risk of ASCVD mainly comes from White people in Europe and North America, lacking representation of East Asian populations. Understanding the association between lipoproteins and lipoprotein cholesterol with risk of ASCVD in East Asia is important for both East Asian and non-East Asian populations worldwide.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Endocrinology & Metabolism
Berit Storgaard Hedegaard, Borge Gronne Nordestgaard, Helle Lynge Kanstrup, Kristian Korsgaard Thomsen, Jan Bech, Lia Evi Bang, Finn Lund Henriksen, Lars Juel Andersen, Thomas Gohr, Linnea Hornbech Larsen, Anne Merete Boas Soja, Frank-Peter Elpert, Tomas Joen Jakobsen, Anette Sjol, Albert Marni Joensen, Ib Christian Klausen, Erik Berg Schmidt, Christian Sorensen Bork
Summary: This study investigated the presence of lipoprotein(a) in individuals referred to Danish lipid clinics and found that elevated lipoprotein(a) played a role in a quarter of individuals who met the diagnosis criteria for clinical familial hypercholesterolemia (FH).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Pooja K. Middha, Xiaoliang Wang, Sabine Behrens, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Javier Benitez, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Daniele Campa, Federico Canzian, Angel Carracedo, Jose E. Castelao, Stephen J. Chanock, Georgia Chenevix-Trench, Emilie Cordina-Duverger, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Laure Dossus, Pierre-Antoine Dugue, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Marike Gabrielson, Manuela Gago-Dominguez, Graham G. Giles, Anna Gonzalez-Neira, Felix Grassmann, Anne Grundy, Pascal Guenel, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Susan E. Hankinson, Elaine F. Harkness, Bernd Holleczek, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Christian Ingvar, Karolin Isaksson, Helena Jernstroem, Esther M. John, Michael E. Jones, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W. Kurian, James V. Lacey, Diether Lambrechts, Nicole L. Larson, Susanna Larsson, Loic Le Marchand, Flavio Lejbkowicz, Shuai Li, Martha Linet, Jolanta Lissowska, Maria Elena Martinez, Tabea Maurer, Anna Marie Mulligan, Claire Mulot, Rachel A. Murphy, William G. Newman, Sune F. Nielsen, Borge G. Nordestgaard, Aaron Norman, Katie M. O'Brien, Janet E. Olson, Alpa V. Patel, Ross Prentice, Erika Rees-Punia, Gad Rennert, Valerie Rhenius, Kathryn J. Ruddy, Dale P. Sandler, Christopher G. Scott, Mitul T. Shah, Xiao-Ou Shu, Ann Smeets, Melissa C. Southey, Jennifer Stone, Rulla M. Tamimi, Jack A. Taylor, Lauren R. Teras, Katarzyna Tomczyk, Melissa A. Troester, Therese Truong, Celine M. Vachon, Sophia S. Wang, Clarice R. Weinberg, Hans Wildiers, Walter Willett, Stacey J. Winham, Alicja Wolk, Xiaohong Yang, M. Pilar Zamora, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Montserrat Garcia-Closas, Marjanka K. Schmidt, Peter Kraft, Roger L. Milne, Sara Lindstroem, Douglas F. Easton, Jenny Chang-Claude
Summary: A genome-wide study identified two independent SNP-risk factor pairs associated with breast cancer risk and estrogen receptor positive (ER +) breast cancer risk. Overall, gene-environment interactions have a very small contribution to the heritability of breast cancer. At the population level, these interactions do not significantly contribute to risk prediction for breast cancer.
BREAST CANCER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jiao Luo, Jesper Qvist Thomassen, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: This study investigated the associations between neutrophil counts and nine cardiovascular endpoints using observational and genetic approaches. The results showed that high neutrophil counts were associated with an increased risk of all cardiovascular outcomes. Genetic studies also supported this finding. No robust associations were found for other types of leukocytes in the two-sample MR analysis.
EUROPEAN HEART JOURNAL
(2023)