Review
Oncology
Yang Zhang, Haiquan Chen
Summary: The National Lung Screening Trial (NLST) showed that LDCT screening can reduce lung cancer mortality by 20.0%. In China, LDCT is affordable and accessible, leading to differences in screening results compared to Western countries. LDCT in China detects a significant proportion of young, female, and non-smoking lung cancer patients with a higher percentage of ADC and early-stage disease. However, concerns about overdiagnosis and overtreatment are also raised.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Oncology
Fangqiu Fu, Yaodong Zhou, Yang Zhang, Haiquan Chen
Summary: Lung cancer is a leading cause of cancer deaths globally. While LDCT screening has proven benefits for high-risk individuals, the question of screening non-high-risk individuals remains debated. A recommended interval of five to ten years for LDCT screening for non-high-risk individuals, based on lung cancer risk, may help reduce unnecessary radiation exposure and decrease lung cancer mortality.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Health Care Sciences & Services
Daniela Amicizia, Maria Francesca Piazza, Francesca Marchini, Matteo Astengo, Federico Grammatico, Alberto Battaglini, Irene Schenone, Camilla Sticchi, Rosa Lavieri, Bruno Di Silverio, Giovanni Battista Andreoli, Filippo Ansaldi
Summary: Lung cancer is the leading cause of cancer-related deaths in Europe, with low survival rates due to late-stage diagnosis. Early detection can significantly improve survival rates, but lung cancer screening is not implemented in Italy. Many countries have implemented screening programs and studies have shown a reduction in mortality.
Article
Critical Care Medicine
Mengyan Wang, Shangqun Lin, Na He, Chen Yang, Ruoxin Zhang, Xing Liu, Chen Suo, Tao Lin, Haiquan Chen, Wanghong Xu
Summary: The increasing use of LDCT in low-risk populations in China has led to lung cancer overdiagnosis, especially in women. Criteria for LDCT screening and management of screening-detected nodules need to be addressed for expanded application in China.
Article
Multidisciplinary Sciences
Szu-Chun Yang, Jung-Der Wang, Shi-Yi Wang
Summary: This study used a nationwide cancer registry and stage shift from a lung cancer trial to adjust for lead-time bias in mortality studies after diagnosis. By comparing life expectancy gained and loss-of-LE saved, the study found that the former approach overestimated the effectiveness of screening, highlighting the importance of adjusting for different distributions in age, sex, and calendar year at early diagnosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Tara Ivic-Pavlicic, Shivam Joshi, Angelo Zegarelli, Emanuela Taioli
Summary: This study examines the impact of eligibility criteria for lung cancer (LC) screening set by the USPSTF and CMS on racial disparities. The current screening criteria, which rely on factors such as age and pack years, contribute to racial disparities in LC screening. More individualized risk assessment methods, including biomarkers of smoking exposure, are needed.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Tara Ivic-Pavlicic, Shivam Joshi, Angelo Zegarelli, Emanuela Taioli
Summary: This study analyzed data from the CDC and found that current lung cancer screening criteria contribute to higher mortality rates among non-White smokers. The study suggests considering more individualized factors, such as smoking biomarkers, when determining screening eligibility.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Caryn E. S. Oshiro, Timothy B. Frankland, Joanne Mor, Carmen P. Wong, Yannica Theda Martinez, Cheryl K. K. Aruga, Stacey Honda
Summary: The study examined racial and ethnic differences in lung cancer screening completion and follow-up rates in a multiethnic population in Hawaii. Disparities were found in completion rates among different racial and ethnic groups, with Asian individuals and their subgroups having higher completion rates.
Review
Oncology
Pierluigi Novellis, Silvia Raimondi Cominesi, Francesca Rossetti, Michele Mondoni, Vanesa Gregorc, Giulia Veronesi
Summary: LDCT is highly sensitive for detecting noninvasive small lung tumors in high-risk populations in Europe. Cost-effectiveness analyses on LCS indicate a favorable economic profile, with different risk models being used to identify target populations and guide screening intervals.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Yeon Wook Kim, Minhee Jeon, Myung Jin Song, Byoung Soo Kwon, Sung Yoon Lim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Kyung Won Lee, Jae Ho Lee, Choon-Taek Lee
Summary: Although LDCT screening is effective for detecting peripheral lung cancers, it does not show improved outcomes for central lung cancers. Developing novel screening modalities is necessary for central lung cancer detection and treatment.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Harris Majeed, Hong Zhu, Sarah A. Williams, Heidi A. Hamann, Vijaya Subbu Natchimuthu, Jessica Lee, Noel O. Santini, Travis Browning, Tanushree Prasad, Joyce O. Adesina, Minh Do, David Balis, Juana Gamarra de Willams, Ellen Kitchell, David H. Johnson, Simon J. Craddock Lee, David E. Gerber
Summary: This study evaluated the prevalence and effects of comorbidities in a real-world population undergoing lung cancer screening. The specific type and degree of comorbidity were found to have no association with the completion and results of the screening.
CLINICAL LUNG CANCER
(2022)
Article
Oncology
Jaeho Lee, Yeol Kim, Hyae Young Kim, Jin Mo Goo, Juntae Lim, Choon-Taek Lee, Seung Hun Jang, Won-Chul Lee, Chan Wha Lee, Kui Son Choi, Boyoung Park, Duk Hyoung Lee
Summary: The K-LUCAS project evaluated the feasibility of implementing a national lung cancer screening program in Korea. Results showed that approximately 15.2% of screening participants had positive results, with about 66.7% of lung cancer patients having early-stage cancer. Additionally, screening helped reduce anxiety levels and encouraged smoking cessation motivation.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Adriana A. Rodriguez Alvarez, Sun Yuming, Jui Kothari, Subba R. Digumarthy, Nicole M. Byrne, Yi Li, David C. Christiani
Summary: This study aimed to evaluate the impact of lung cancer screening on survival rates between females and males. The study found that unscreened females had a lower risk of mortality and better survival than unscreened males, while there was no significant difference in overall survival between sexes among the screened population.
Article
Geriatrics & Gerontology
Leon Lenchik, Ryan Barnard, Robert D. Boutin, Stephen B. Kritchevsky, Haiying Chen, Josh Tan, Peggy M. Cawthon, Ashley A. Weaver, Fang-Chi Hsu
Summary: This study developed a fully automated method for muscle measurement on CT images and found that higher paraspinous skeletal muscle area and skeletal muscle density were associated with better survival in older men, but not in women.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Oncology
Reza Zarinshenas, Arya Amini, Isa Mambetsariev, Tariq Abuali, Jeremy Fricke, Colton Ladbury, Ravi Salgia
Summary: This review summarizes the advancements in lung cancer management, including the importance of screening, the challenges in early-stage diagnosis and biomarker testing, and the potential opportunities for improvement. It also highlights the significance of a multidisciplinary approach and the impact of early detection on patient outcomes.
Article
Oncology
Luigi Ventura, Paolo Carbognani, Letizia Gnetti, Maurizio Rossi, Marcello Tiseo, Enrico Maria Silini, Nicola Sverzellati, Mario Silva, Marcello Succi, Cesare Braggio, Sara Cattadori, Giovanni Bocchialini, Valeria Balestra, Michele Rusca, Luca Ampollini
Summary: The study aimed to explore the clinical features and prognosis of patients with multiple primary malignancies (MPM). The results showed that MPM incidence was 19.8%, with male sex, squamous cell lung carcinoma, synchronous and LCF MPM associated with poorer overall survival.
Article
Rheumatology
Aldo Carnevale, Mario Silva, Elisa Maietti, Gianluca Milanese, Marta Saracco, Simone Parisi, Elena Bravi, Fabio De Gennaro, Eugenio Arrigoni, Flavio Cesare Bodini, Enrico Fusaro, Carlo Alberto Scire, Nicola Sverzellati, Alarico Ariani
Summary: This study aimed to determine the correlation between functional and radiological changes in patients with SSc-ILD, and tested the OMERACT criteria's ability to predict ILD evolution. It was found that changes in radiological extent were correlated to functional decline in a limited time frame. Repeated HRCT every 12-24 months could detect early progression in SSc-ILD, even in patients with stable pulmonary function, and OMERACT criteria might overlook some cases of radiological progression.
CLINICAL RHEUMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Gianluca Milanese, Stefano Sestini, Federica Sabia, Colin Jacobs, Bram van Ginneken, Mathias Prokop, Cornelia M. Schaefer-Prokop, Alfonso Marchiano, Nicola Sverzellati, Ugo Pastorino
Summary: This study analyzed the distribution of Lung-RADS v1.1 volumetric categories and lung cancer outcomes within 3 years in order to explore personalized algorithm for lung cancer screening. It found that nodule volume was a strong predictor of lung cancer risk and personalized screening algorithm by increased interval seems feasible in 80% of NLST eligible participants.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Roberta Eufrasia Ledda, Mark Schiebler, Maurizio Balbi, Sandro Sironi, Francesca Milone, Paola Affanni, Gianluca Milanese, Nicola Sverzellati
Summary: Ancillary findings of COVID-19 pneumonia on CT, including vessel enlargement, subpleural curvilinear lines, and dependent subpleural atelectasis, are associated with disease severity and clinical parameters. These findings may provide additional insights into disease progression and phenotyping.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Michele Maddalo, Eleonora Leoni, Sara Giuliotti, Gianluca Milanese, Caterina Ghetti, Elisabetta Biasini, Massimo De Filippo, Gabriele Missale, Nicola Sverzellati
Summary: This study evaluated the prognostic value of radiomics in IMCC patients and developed a comprehensive risk model. The study found that radiomic features can stratify overall survival and the dichotomized RSign* can classify survival strata, showing an adjunct yield in risk models. However, the cut-off value of RSign* varied between readers, indicating limitations due to interobserver variability.
ABDOMINAL RADIOLOGY
(2021)
Article
Oncology
U. Pastorino, M. Boeri, S. Sestini, F. Sabia, G. Milanese, M. Silva, P. Suatoni, C. Verri, A. Cantarutti, N. Sverzellati, G. Corrao, A. Marchiano, G. Sozzi
Summary: This study predicts individual lung cancer incidence and mortality by combining LDCT and blood miRNAs, and finds that MSC has a significant impact on LDCT-positive individuals.
ANNALS OF ONCOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Gianluca Milanese, Roberta E. Ledda, Sundeep M. Nayak, Ugo Pastorino, Nicola Sverzellati
Summary: This article provides a detailed description of the challenges and potential solutions in the practice of low-dose computed tomography lung cancer screening, aiming to help the readers understand and apply it effectively.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Virology
Emanuele Montomoli, Giovanni Apolone, Alessandro Manenti, Mattia Boeri, Paola Suatoni, Federica Sabia, Alfonso Marchiano, Valentina Bollati, Ugo Pastorino, Gabriella Sozzi
Summary: The rapid outbreak of COVID-19 suggests the possibility of undetected earlier circulation of the SARS-CoV-2 virus. Testing of pre-pandemic samples from Italy showed the presence of SARS-CoV-2 antibodies, indicating possible infection before the pandemic. These findings highlight the importance of harmonizing serological assays for testing the spread of the virus and may contribute to a better understanding of future virus dynamics.
Article
Oncology
Arsela Prelaj, Mattia Boeri, Alessandro Robuschi, Roberto Ferrara, Claudia Proto, Giuseppe Lo Russo, Giulia Galli, Alessandro De Toma, Marta Brambilla, Mario Occhipinti, Sara Manglaviti, Teresa Beninato, Achille Bottiglieri, Giacomo Massa, Emma Zattarin, Rosaria Gallucci, Edoardo Gregorio Galli, Monica Ganzinelli, Gabriella Sozzi, Filippo G. M. de Braud, Marina Chiara Garassino, Marcello Restelli, Alessandra Laura Giulia Pedrocchi, Francesco Trovo
Summary: This study demonstrates the usefulness of artificial intelligence and machine learning tools in predicting the response and efficacy of immunotherapy in non-small cell lung cancer patients. By integrating multifactorial data, these tools can assist in selecting candidates for immunotherapy.
Article
Chemistry, Medicinal
Massimo Moro, Orazio Fortunato, Giulia Bertolini, Mavis Mensah, Cristina Borzi, Giovanni Centonze, Francesca Andriani, Daniela Di Paolo, Patrizia Perri, Mirco Ponzoni, Ugo Pastorino, Gabriella Sozzi, Mattia Boeri
Summary: Despite improvements in therapies and screening strategies, lung cancer prognosis remains poor, especially for patients with metastatic tumors. Cancer stem cells (CSCs) are a major cause of the low survival rate, and microRNA miR-486-5p has been identified as a potential therapeutic target for lung cancer.
Article
Critical Care Medicine
Simon L. F. Walsh, John A. Mackintosh, Lucio Calandriello, Mario Silva, Nicola Sverzellati, Anna Rita Larici, Stephen M. Humphries, David A. Lynch, Helen E. Jo, Ian Glaspole, Christopher Grainge, Nicole Goh, Peter M. A. Hopkins, Yuben Moodley, Paul N. Reynolds, Christopher Zappala, Gregory Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Ellis, Athol U. Wells, Tamera J. Corte
Summary: This study evaluated the prognostic accuracy of a deep learning algorithm for predicting outcomes in patients with fibrotic lung disease using high-resolution computed tomography (HRCT) data. The results showed that this algorithm outperformed expert radiologist evaluation and guideline-based histologic pattern in predicting survival. It has the potential to be a useful tool in characterizing fibrotic lung disease in a multidisciplinary approach. Further research is needed to investigate its utility as a decision support system when interstitial lung disease expertise is unavailable.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Oncology
Wieland Voigt, Helmut Prosch, Mario Silva
Summary: Early detection is crucial for successful treatment of lung cancer. Low dose computed tomography (LDCT) screening is an effective tool for early detection, but candidate selection and technical advancements are important considerations. In this review, we discuss current limitations and advances in lung cancer screening and the integration of scientific and technological progress to improve its performance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Giulia Picozzi, Nicola Sverzellati, Sandra Anglesio, Maurizio Bartolucci, Edoardo Cavigli, Annalisa Deliperi, Massimo Falchini, Fabio Falaschi, Domenico Ghio, Paola Gollini, Anna Rita Larici, Alfonso Marchiano, Stefano Palmucci, Lorenzo Preda, Chiara Romei, Carlo Tessa, Cristiano Rampinelli, Mario Mascalchi
Summary: Smoking is the main risk factor for lung cancer, and low dose computed tomography (LDCT) screening has been proven to reduce lung cancer mortality, especially in women. Several Italian initiatives are currently offering LDCT screening and smoking cessation to high-risk individuals, with the aim of implementing a population-based screening program. This position paper provides recommendations for LDCT scan protocol, nodule classification, and management based on international guidelines.
Article
Computer Science, Artificial Intelligence
Colin Jacobs, Arnaud A. A. Setio, Ernst T. Scholten, Paul K. Gerke, Haimasree Bhattacharya, Firdaus A. M. Hoesein, Monique Brink, Erik Ranschaert, Pim A. de Jong, Mario Silva, Bram Geurts, Kaman Chung, Steven Schalekamp, Joke Meersschaert, Anand Devaraj, Paul F. Pinsky, Stephen C. Lam, Bram van Ginneken, Keyvan Farahani
Summary: The study showed that deep learning algorithms developed in a public competition for lung cancer detection on low-dose CT scans reached performance close to that of radiologists, with the average performance of radiologists slightly higher than these algorithms.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2021)
Article
Oncology
Giovanni Apolone, Emanuele Montomoli, Alessandro Manenti, Mattia Boeri, Federica Sabia, Inesa Hyseni, Livia Mazzini, Donata Martinuzzi, Laura Cantone, Gianluca Milanese, Stefano Sestini, Paola Suatoni, Alfonso Marchiano, Valentina Bollati, Gabriella Sozzi, Ugo Pastorino
Summary: The study found that the SARS-CoV-2 virus began circulating in Italy as early as September 2019 among asymptomatic individuals, shedding light on the origin and spread of the COVID-19 pandemic.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)