Partially inserted nascent chain unzips the lateral gate of the Sec translocon

Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations

(2018) Elisabet C. Mandon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific cardiolipin–SecY interactions are required for proton-motive force stimulation of protein secretion

(2018) Robin A. Corey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY

(2018) Narcis-Adrian Petriman et al.   Scientific Reports

Lipids modulate the insertion and folding of the nascent chains of alpha helical membrane proteins

(2018) Nicola J. Harris et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Forces on Nascent Polypeptides during Membrane Insertion and Translocation via the Sec Translocon

(2018) Michiel J.M. Niesen et al.   BIOPHYSICAL JOURNAL

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Organization of the native ribosome–translocon complex at the mammalian endoplasmic reticulum membrane

(2016) Stefan Pfeffer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers

(2016) Daniela Diedrich et al.   CHEMISTRY-A EUROPEAN JOURNAL

Lipids Activate SecA for High Affinity Binding to the SecYEG Complex

(2016) Sabrina Koch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

(2016) Ahmad Jomaa et al.   Nature Communications

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis

(2016) Alexej Kedrov et al.   Cell Reports

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies

(2016) Benedikt Frieg et al.   PLoS Computational Biology

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Mechanisms of Integral Membrane Protein Insertion and Folding

(2015) Florian Cymer et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structures of SecYEG in Lipidic Cubic Phase Elucidate a Precise Resting and a Peptide-Bound State

(2015) Yoshiki Tanaka et al.   Cell Reports

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Escherichia coli SecG Is Required for Residual Export Mediated by Mutant Signal Sequences and for SecY-SecE Complex Stability

(2014) Dominique Belin et al.   JOURNAL OF BACTERIOLOGY

Dynamic Interaction of the Sec Translocon with the Chaperone PpiD

(2014) Ilie Sachelaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YfgM Is an Ancillary Subunit of the SecYEG Translocon inEscherichia coli

(2014) Hansjörg Götzke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Architecture and conformational switch mechanism of the ryanodine receptor

(2014) Rouslan G. Efremov et al.   NATURE

Visualization of a polytopic membrane protein during SecY-mediated membrane insertion

(2014) Lukas Bischoff et al.   Nature Communications

A structural model of the active ribosome-bound membrane protein insertase YidC

(2014) Stephan Wickles et al.   eLife

Helical membrane protein conformations and their environment

(2013) Timothy A. Cross et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald

(2013) Romelia Salomon-Ferrer et al.   Journal of Chemical Theory and Computation

Elucidating the Native Architecture of the YidC: Ribosome Complex

(2013) Alexej Kedrov et al.   JOURNAL OF MOLECULAR BIOLOGY

Monitoring the Activity of Single Translocons

(2013) Intan Taufik et al.   JOURNAL OF MOLECULAR BIOLOGY

Optimized Phospholipid Bilayer Nanodiscs Facilitate High-Resolution Structure Determination of Membrane Proteins

(2013) Franz Hagn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the SecY channel during initiation of protein translocation

(2013) Eunyong Park et al.   NATURE

Transitions to catalytically inactive conformations in EGFR kinase

(2013) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomolecular Simulation: A Computational Microscope for Molecular Biology

(2012) Ron O. Dror et al.   Annual Review of Biophysics

Competitive Binding of the SecA ATPase and Ribosomes to the SecYEG Translocon

(2012) Zht Cheng Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial protein translocation requires only one copy of the SecY complex in vivo

(2012) Eunyong Park et al.   JOURNAL OF CELL BIOLOGY

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

(2012) Levi C.T. Pierce et al.   Journal of Chemical Theory and Computation

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration

(2012) Nurzian Ismail et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the SecY Complex Unlocked by a Preprotein Mimic

(2012) Dilem Hizlan et al.   Cell Reports

Membrane Protein Insertion at the Endoplasmic Reticulum

(2011) Sichen Shao et al.   Annual Review of Cell and Developmental Biology

A single copy of SecYEG is sufficient for preprotein translocation

(2011) Alexej Kedrov et al.   EMBO JOURNAL

Conformational Dynamics of the Plug Domain of the SecYEG Protein-conducting Channel

(2011) Jelger A. Lycklama a Nijeholt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

(2011) Jens Frauenfeld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation mechanism of the  2-adrenergic receptor

(2011) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

(2010) P. F. Egea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-Dependent Membrane Protein Topogenesis

(2009) William Dowhan et al.   Annual Review of Biochemistry

Signal peptides are allosteric activators of the protein translocase

(2009) Giorgos Gouridis et al.   NATURE

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations

(2008) In Suk Joung et al.   JOURNAL OF PHYSICAL CHEMISTRY B