期刊
EMBO REPORTS
卷 20, 期 11, 页码 -出版社
WILEY
DOI: 10.15252/embr.201947965
关键词
BIK1; Flg22-triggered immunity
资金
- King Abdullah University of Science and Technology [BAS/1/1062-01-01, URF/1/2965-01-01]
- LabEx Saclay Plant Sciences-SPS [ANR-10-LABX-0040-SPS]
To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor-like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1-mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22-induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.
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