标题
Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities
作者
关键词
-
出版物
DRUG METABOLISM AND DISPOSITION
Volume 47, Issue 10, Pages 1097-1099
出版商
American Society for Pharmacology & Experimental Therapeutics (ASPET)
发表日期
2019-08-10
DOI
10.1124/dmd.119.088708
参考文献
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- (2019) Sara C. Humphreys et al. Nucleic Acid Therapeutics
- Fresh from the biotech pipeline—2018
- (2019) Chris Morrison NATURE BIOTECHNOLOGY
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- (2019) Amita Datta-Mannan DRUG METABOLISM AND DISPOSITION
- Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates
- (2019) Donglu Zhang et al. DRUG METABOLISM AND DISPOSITION
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- (2019) Sara C Humphreys et al. DRUG METABOLISM AND DISPOSITION
- Top 15 Best-Selling Drugs of 2018
- (2019) Alex Philippidis Genetic Engineering & Biotechnology News
- siRNA therapeutics: a clinical reality
- (2019) Phei Er Saw et al. Science China-Life Sciences
- Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities
- (2019) Donglu Zhang et al. DRUG METABOLISM AND DISPOSITION
- In Vitro Drug-Drug Interaction Evaluation of GalNAc conjugated siRNAs Against CYP450 Enzymes and Transporters
- (2019) Diane Ramsden et al. DRUG METABOLISM AND DISPOSITION
- Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
- (2019) Donglu Zhang et al. DRUG METABOLISM AND DISPOSITION
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- (2019) Noah Post et al. DRUG METABOLISM AND DISPOSITION
- Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species
- (2019) Robert S. Foti et al. DRUG METABOLISM AND DISPOSITION
- Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development
- (2018) Shalini Andersson et al. DRUG DISCOVERY TODAY
- Evolutionary and genetic features of drug targets
- (2018) Yuan Quan et al. MEDICINAL RESEARCH REVIEWS
- 2017 FDA drug approvals
- (2018) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
- (2017) Tracy S. Zimmermann et al. MOLECULAR THERAPY
- Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
- (2017) Jayaprakash K. Nair et al. NUCLEIC ACIDS RESEARCH
- The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market
- (2017) Ricardo Titze-de-Almeida et al. PHARMACEUTICAL RESEARCH
- Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies
- (2016) Patrick M. Glassman et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Altering Antibody–Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability
- (2016) Kevin J. Hamblett et al. MOLECULAR PHARMACEUTICS
- A comprehensive map of molecular drug targets
- (2016) Rita Santos et al. NATURE REVIEWS DRUG DISCOVERY
- Antibody-drug conjugates: recent advances in conjugation and linker chemistries
- (2016) Kyoji Tsuchikama et al. Protein & Cell
- Antibody Drug Conjugates: Preclinical Considerations
- (2015) Gadi G. Bornstein AAPS Journal
- Assessments of antibody biodistribution
- (2015) Patrick M. Glassman et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics
- (2015) Dhaval K. Shah JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development
- (2015) Jay Tibbitts et al. mAbs
- Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development
- (2015) Aman P. Singh et al. PHARMACEUTICAL RESEARCH
- Bioanalytical approaches to assess the proteolytic stability of therapeutic fusion proteins
- (2015) Josh T Pearson et al. Bioanalysis
- Next-generation optimized biotherapeutics — A review and preclinical study
- (2014) Tadashi Ueda BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives
- (2013) Tjerk Bueters et al. DRUG DISCOVERY TODAY
- Antibody biodistribution coefficients
- (2013) Dhaval K. Shah et al. mAbs
- Challenges and Opportunities in Absorption, Distribution, Metabolism, and Excretion Studies of Therapeutic Biologics
- (2012) Xin Xu et al. AAPS Journal
- Pharmacokinetics of Biotech Drugs: Peptides, Proteins and Monoclonal Antibodies
- (2009) Jiunn Lin CURRENT DRUG METABOLISM
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