Article
Biochemistry & Molecular Biology
Ewa Stepien, Jakub Dworzanski, Anna Dworzanska, Bartlomiej Drop, Malgorzata Polz-Dacewicz
Summary: In patients with type 2 diabetes, EBV infection may lead to significant differences in the concentration of MMP-3 and MMP-9. MMPs may be useful biomarkers in the diagnosis, prognosis, and monitoring of diabetes associated with EBV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Qinghe Meng, Xiaojing Wang, Dandan Guo, Changying Shi, Raymond Gu, Julia Ma, Gary Nieman, Michaela Kollisch-Singule, Juntao Luo, Robert N. Cooney
Summary: This study found that intratracheal nano-formulation of CMT-3 can attenuate LPS-induced acute lung injury and inflammation through multiple mechanisms, demonstrating significant anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Yu-Hsiang Chang, Yuan-Li Huang, Hsiao-Chi Tsai, An-Chen Chang, Chih-Yuan Ko, Yi-Chin Fong, Chih-Hsin Tang
Summary: This study aims to investigate the role of miRNAs in CCL2-mediated MMP expression and cell motility in human osteosarcoma. The results demonstrate a positive correlation between CCL2 or MMP-3 levels and osteosarcoma metastasis, and stimulation of osteosarcoma cells with CCL2 enhances migration and invasion abilities. Additionally, CCL2 enhances MMP-3-dependent cell motility by inhibiting miR-3659 synthesis.
Article
Biochemistry & Molecular Biology
Shu Zhang, Hui Wang, Pengfei Mao, Qi Sun, Haochen Su, Yixuan Zhang, Shanshan Shen, Guifang Xu, Lei Wang, Xiaoping Zou, Qiang Zhan, Ying Lv
Summary: This study found that PTPN2 is downregulated in PDAC tissues and its reduced expression is associated with poor prognosis. Functional studies showed that PTPN2 knockdown promotes the migration and invasion abilities of PDAC cells and liver metastasis. Mechanistically, PTPN2 depletion activates MMP-1 through regulating the interaction of p-STAT3 with its promoter in PDAC progression.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Deep Sankar Rudra, Uttam Pal, Nilkanta Chowdhury, Nakul Chandra Maiti, Angshuman Bagchi, Snehasikta Swarnakar
Summary: The repairing of damaged tissues in the gastric tract starts with extracellular matrix remodeling by matrix metalloproteinases (MMPs). The drug omeprazole, used to cure gastric ulcers, has been shown to restore MMP-2 activity and reduce apoptosis, preventing stress-induced gastric ulcers by modulating NF-kappa B and PPAR-gamma activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Masoud Nakhaei, Mathew Bligh, Victoria Chernyak, Abraham F. Bezuidenhout, Alexander Brook, Olga R. Brook
Summary: After long-term follow-up, the risk of pancreatic malignancy in patients with asymptomatic small pancreatic cysts was found to be 0.9 cases per 1,000 patient-years, similar to those without cysts. Very few cases of pancreatic cancer developed in areas separate from the known cysts.
EUROPEAN RADIOLOGY
(2022)
Review
Medicine, General & Internal
Marco Del Chiaro, Robert J. Torphy, Richard D. Schulick
Summary: The incidence of pancreatic incidentalomas is increasing with the use of advanced imaging techniques, particularly in the general population. Proper management involves accurate characterization using dedicated imaging protocols, followed by tailored diagnosis and subsequent treatment based on the type of lesion.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Multidisciplinary Sciences
Shanshan Wang, Xin You, Xiaoshu Liu, Fengwei Zhang, Hongjuan Zhou, Xuechai Shang, Long Cai
Summary: This study investigates the contribution of histone methyltransferase SMYD3 to sorafenib resistance in hepatocellular carcinoma (HCC). SMYD3 was found to be significantly elevated in sorafenib-resistant tumors and cells. Functional studies demonstrated that SMYD3 promotes the migration, invasion, metastasis, and stemness of sorafenib-resistant HCC cells. Mechanistically, SMYD3 is required for SMAD2/3-mediated epithelial-mesenchymal transition (EMT) in sorafenib-resistant HCC cells by promoting the expression of SOX4, ZEB1, SNAIL1, and MMP9 genes.
Article
Biochemistry & Molecular Biology
Arno Kirchhain, Asta Zubriene, Visvaldas Kairys, Federico Vivaldi, Andrea Bonini, Denise Biagini, Delio Santalucia, Daumantas Matulis, Fabio Di Francesco
Summary: Matrix metalloproteinases play a crucial role in cancer progression and metastasis, and molecular probes have been successfully used to study their activity. In this study, a series of MMP-2 and MMP-9 binding probes were synthesized, showing high selectivity against MMP-2 and potential for sensor fabrication. The experimental results were confirmed by molecular modeling, indicating the potential application of these probes for targeted enzyme detection.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Huan Wang, Sihai Chen, Xu Shu, Zhijian Liu, Pi Liu, Yong Zhu, Yin Zhu, Huifang Xiong
Summary: This study investigated the value of serum tumor markers and inflammation-related biomarkers in the differentiation of pancreatic serous cystic neoplasms (SCNs) and pancreatic mucinous cystic neoplasms (MCNs). The results showed that CA199 and LA had good efficiency in the differential diagnosis of SCNs and MCNs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marcela Silva dos Santos, Marcio Marcal Lobo, Simone Schneider Amaral, Nilo Zanatta, Cassiana Macagnan Viau, Jenifer Saffi
Summary: The study demonstrates that compound 9c induces cell cycle arrest in G2/M phase, increases levels of reactive oxygen species and DNA damage, and triggers DNA damage response by ATM and histone H2AX phosphorylation induction in PC-3 cells. Additionally, compound 9c leads to lipid peroxidation and mitochondrial depolarization, activating the intrinsic pathway and increasing cleaved caspase-9 and 3. Furthermore, 9c reduces vascular endothelial growth factor expression (VEGF) and inhibits topoisomerase I enzyme, indicating its potential as a new molecule for further investigation in prostate cancer management.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Jiajun Liu, Fangzheng Wu, Minghui Wang, Menglin Tao, Zhengjie Liu, Zijuan Hai
Summary: A tumor-targeted fluorescent/photoacoustic probe was developed to monitor the activity of Caspase-3 in vivo. The probe could enter and accumulate in tumor cells, resulting in increased fluorescence and photoacoustic signals. This study provides a new method for clinical imaging of tumor apoptosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Magda M. F. Ismail, Taghreed Z. Shawer, Rabab S. Ibrahim, Mostafa S. Abusaif, Mona M. Kamal, Rasha M. Allam, Yousry A. Ammar
Summary: This study discovered seventeen novel quinoxaline-3-propanamides that exhibited strong cytotoxic activity against colon cancer and breast cancer cells by targeting vascular endothelial growth factor receptor-2. These compounds showed higher selectivity and cytotoxicity compared to reference drugs, and they effectively inhibited angiogenesis and induced apoptosis through various pathways.