Article
Gastroenterology & Hepatology
Essi K. Karjalainen, Laura Renkonen-Sinisalo, Reetta Satokari, Harri Mustonen, Ari Ristimaki, Perttu Arkkila, Anna H. Lepisto
Summary: The fecal microbiota transplantation treatment did not show efficacy in treating chronic pouchitis, however the safety profile was good. Among patients who were using continuous antibiotics before the study, the relapse-free survival was shorter in the intervention group.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Olga Brusnic, Danusia Maria Onisor, Amedeo Amedei, Ryota Niikura
Summary: Imbalances in the gut microbiota play a crucial role in the development of liver diseases, and fecal microbiota transplantation has shown promise as an effective treatment for chronic liver diseases and cirrhosis.
Article
Microbiology
Zhi-Luo Deng, Dietmar H. Pieper, Andreas Stallmach, Arndt Steube, Marius Vital, Michael Reck, Irene Wagner-Dobler
Summary: This study reveals that FMT leads to a temporary engraftment of donor microbiota, particularly in butyrate biosynthesis, which helps alleviate pouchitis. However, this engraftment is short-lived and needs to be repeated to achieve therapeutic effects.
Review
Gastroenterology & Hepatology
Rohma Ghani, Benjamin H. Mullish, Lauren A. Roberts, Frances J. Davies, Julian R. Marchesi
Summary: Disruption to the intestinal microbiota increases the risk of infection, and restoring its composition is a potential strategy to mitigate this risk. Fecal microbiota transplantation is currently the major therapeutic approach, with potential use in treating other infectious diseases.
Review
Gastroenterology & Hepatology
Shaghayegh Habibi, Armin Rashidi
Summary: Disruptions to the gut microbiota have been linked to adverse outcomes after hematopoietic cell transplantation and cellular therapy. Fecal microbiota transplantation (FMT) is a potential therapeutic intervention, but more research is needed before it can be considered a standard treatment. This review examines the evidence for microbiota-outcome associations, highlights the main FMT trials, and suggests future paths for research.
Article
Gastroenterology & Hepatology
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Summary: Fecal microbiota transplantation is an effective strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome. For patients with IBS-D, FMT with antibiotic pretreatment significantly reduces bacterial engraftment.
Review
Immunology
Hui Xu, Chenxi Cao, Yuqing Ren, Siyuan Weng, Long Liu, Chunguang Guo, Libo Wang, Xinwei Han, Jianzhuang Ren, Zaoqu Liu
Summary: This review systematically summarizes the role of fecal microbiome transplantation (FMT) in regulating tumor immunity and highlights its importance in treating refractory tumors and improving the efficacy of immunotherapy. Ongoing clinical trials combining FMT with immunotherapy are also summarized, along with a focus on refined protocols for FMT in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Jing Xu, Mingzhu Wang, Qiuping Liu, Xiaoying Lin, Kefeng Pu, Zhixing He
Summary: Nitrite has toxic effects on mice, and gut microbiota can mediate the toxicity of nitrite. High doses of nitrite can cause dysbiosis in the gut microbiota, affecting metabolism and stress response.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Veterinary Sciences
Maimaiti Tuniyazi, Wenqing Wang, Naisheng Zhang
Summary: Fecal microbiota transplantation (FMT) is a technique that involves transferring fecal matter from a healthy donor to a recipient in order to restore a healthy gut microbiome. It has been used in horses to treat gastrointestinal disorders such as colitis and diarrhea. The authors conducted a systematic review of the existing literature to evaluate the efficacy, safety, and potential applications of FMT in horses.
VETERINARY SCIENCES
(2023)
Review
Medicine, General & Internal
Yuanyuan Zhao, Chen Gong, Jing Xu, Dong Chen, Bo Yang, Zhishui Chen, Lai Wei
Summary: A growing body of evidence suggests that gut microbiota plays a role in liver diseases through the gut-liver axis. The imbalance of gut microbiota is associated with various liver diseases, including ALD, NAFLD, viral hepatitis, cirrhosis, PSC, and HCC. FMT, as a method to restore the gut microbiota, has been widely studied and regarded in clinical trials. This review summarizes the role of FMT in liver disease treatment, explores the gut-liver axis, and discusses the definition, objectives, advantages, and procedures of FMT. The clinical value of FMT therapy in LT recipients is also briefly discussed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Lena Van Dingenen, Charlotte Segers, Shari Wouters, Mohamed Mysara, Natalie Leys, Samir Kumar-Singh, Surbhi Malhotra-Kumar, Rob Van Houdt
Summary: Colorectal cancer is a common and burdensome disease. Current treatment includes surgery, chemotherapy, radiotherapy, and immunotherapy. The gut microbiome may influence treatment efficacy and toxicity, and fecal microbiota transplantation can reduce toxicity and enhance efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ning He, Gerong Shen, Xiaoqin Jin, Heyangzi Li, Jingyu Wang, Lintao Xu, Jun Chen, Xi Cao, Chunyan Fu, Dongling Shi, Xinghui Song, Shuangshuang Liu, Yanwei Li, Tengfei Zhao, Jun Li, Jinjie Zhong, Yueliang Shen, Mingzhi Zheng, Ying-ying Chen, Lin-lin Wang
Summary: Spinal cord injury can alter the gut microbiota and metabolites, affecting the prognosis of the injury. Resveratrol, with its anti-inflammatory properties, can restore the disrupted gut microbiota and increase the concentration of butyrate, promoting functional recovery after spinal cord injury.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Qiaomai Xu, Shumeng Zhang, Jiazheng Quan, Zhengjie Wu, Silan Gu, Yunbo Chen, Beiwen Zheng, Longxian Lv, Lanjuan Li
Summary: Vancomycin is the preferred treatment for CDI but has a high recurrence rate. FMT has emerged as a successful treatment for recurrent CDI. Our study suggests that FMT can better restore gut microbiota and metabolites, promoting the recovery of colonization resistance in mice compared to vancomycin.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Sijia Fang, Shan Wu, Lina Ji, Yongsheng Fan, Xinchang Wang, Kepeng Yang
Summary: Meta-analysis of FMT and laxatives in functional constipation showed that combined therapy had significantly higher total effective rate, improved stool form scale score, reduced severity of constipation, and enhanced quality of life compared to using laxatives alone. However, caution is needed due to poor methodological quality and the need for further exploration in larger studies.
Letter
Gastroenterology & Hepatology
Craig Haifer, Aiasha Saikal, Ramesh Paramsothy, Nadeem O. Kaakoush, Rupert W. Leong, Thomas J. Borody, Michael A. Kamm, Sudarshan Paramsothy
Article
Genetics & Heredity
Nandan P. Deshpande, Stephen M. Riordan, Claire J. Gorman, Shaun Nielsen, Tonia L. Russell, Carolina Correa-Ospina, Bentotage S. M. Fernando, Shafagh A. Waters, Natalia Castano-Rodriguez, Si Ming Man, Nicodemus Tedla, Marc R. Wilkins, Nadeem O. Kaakoush
Summary: This study comprehensively assessed the esophageal microenvironment in patients with gastro-esophageal reflux disease and metaplasia, identifying bacterial strain-specific signatures with high relevance to disease progression.
Article
Gastroenterology & Hepatology
Laurence Don Wai Luu, Georgia Popple, Samuel Pok Wei Tsang, Karla Vinasco, Ida Hilmi, Ruey Terng Ng, Kee Seang Chew, Shin Yee Wong, Stephen Riordan, Way Seah Lee, Hazel M. Mitchell, Nadeem O. Kaakoush, Natalia Castano-Rodriguez
Summary: This study identified eight SNPs associated with IBD and/or its subtypes in the Malaysian population, significantly advancing our understanding of the genetic contribution to IBD in this understudied population. Three of these SNPs modulated relevant cytokine levels and thus, may directly contribute to IBD pathogenesis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Obstetrics & Gynecology
Monica Shahid, Julie A. Quinlivan, Michael Peek, Natalia Castano-Rodriguez, George L. Mendz
Summary: The study showed significant differences in the vaginal microbiomes between women who miscarried and those who delivered at term, both in overall microbiome populations and in the abundances of individual taxa. The composition of the vaginal microbiome was found to vary with pregnancy history.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Review
Cell Biology
Laurence Don Wai Luu, Nadeem O. Kaakoush, Natalia Castano-Rodriguez
Summary: Macroautophagy/autophagy is a crucial cell process for human health, and ATG16L2, a protein related to autophagy, plays a significant role in various cancers and chronic diseases. However, there is still limited research on ATG16L2, and its function in autophagy remains unknown.
Article
Oncology
Sabrina E. Wang, S. Ghazaleh Dashti, Allison M. Hodge, Suzanne C. Dixon-Suen, Natalia Castano-Rodriguez, Robert J. S. Thomas, Graham G. Giles, Roger L. Milne, Alex Boussioutas, Bradley J. Kendall, Dallas R. English
Summary: The study found that men, but not women, who were H. pylori sero-negative had increased risks of GERD and Barrett's esophagus, possibly due to differences in patterns of H. pylori-induced atrophic antral gastritis between sexes.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Gastroenterology & Hepatology
Craig Haifer, Laurence Don Wai Luu, Sudarshan Paramsothy, Thomas J. Borody, Rupert W. Leong, Nadeem O. Kaakoush
Summary: This study characterized the differences in gut microbiota between two FMT donors and found that donor microbiota stability and species evenness were associated with therapeutic efficacy in UC. These findings have important implications for improving FMT donor selection.
Review
Cell Biology
Apeksha Bharatgiri Goswami, Dimitrije Karadarevic, Natalia Castano-Rodriguez
Summary: IRGM plays a crucial role in regulating autophagy and inflammation, impacting inflammatory diseases and cancer development. Its polymorphisms are functionally relevant to autophagic and inflammatory responses.
INFLAMMATION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Valentina Rodriguez Paris, Xin Yi Denise Wong, Samantha M. Solon-Biet, Melissa C. Edwards, Ali Aflatounian, Robert B. Gilchrist, Stephen J. Simpson, David J. Handelsman, Nadeem O. Kaakoush, Kirsty A. Walters
Summary: The study found that diet influences gut microbiota diversity, but overall gut microbiota composition is affected by PCOS pathology. The role of the gut microbiome in the development of PCOS traits was explored, and PCOS-like mice transplanted with healthy fecal microbiota did not show improvement in PCOS traits.
Article
Food Science & Technology
Michael D. Kendig, Kyoko Hasebe, Aynaz Tajaddini, Nadeem O. Kaakoush, R. Frederick Westbrook, Margaret J. Morris
Summary: This study examines the effects of a diet switch intervention in a rat model of maternal obesity. The results show that the intervention leads to reductions in body weight and adiposity, improvements in place recognition memory, and changes in gut microbiota composition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Genetics & Heredity
Laurence D. W. Luu, Harveen Singh, Natalia Castano-Rodriguez, Steven T. Leach, Stephen M. Riordan, Nicodemus Tedla, Usha Krishnan, Nadeem O. Kaakoush
Summary: This study investigates the diversity of upper gastrointestinal microbiotas in pediatric patients. It finds significant differences in bacterial diversity and composition among oral, esophageal, and gastric samples, while fungi show no replication of these differences. Reflux leads to increased homogeneity in the bacterial component of these microbiotas. Oral and esophageal microbiotas are associated with age, sex, history of esophageal atresia, and the presence of esophageal metaplasia. Proton pump inhibitor use is associated with increased oral bacterial richness in the gastric fluid and increased levels of gastric pro-inflammatory cytokines.
MICROBIAL GENOMICS
(2022)
Letter
Gastroenterology & Hepatology
John David Chetwood, Sudarshan Paramsothy, Craig Haifer, Rupert W. Leong, Nadeem O. Kaakoush
Article
Gastroenterology & Hepatology
Isidora Simovic, Ida Hilmi, Ruey Terng Ng, Kee Seang Chew, Shin Yee Wong, Way Seah Lee, Stephen Riordan, Natalia Castano-Rodriguez
Summary: ATG16L1 rs2241880 is significantly associated with susceptibility to Crohn's disease (CD) and influences clinical outcomes, especially in Caucasian populations.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
