Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance

AIM2 regulates vascular smooth muscle cell migration in atherosclerosis

(2018) Jinyu Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AIM2 accelerates the atherosclerotic plaque progressions in ApoE−/− mice

(2018) Jinyu Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Ifi202b/IFI16 expression stimulates adipogenesis in mice and humans

(2018) Mandy Stadion et al.   DIABETOLOGIA

AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality

(2017) Hongbo Zhang et al.   JOURNAL OF IMMUNOLOGY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

(2016) Andrew J. Murphy et al.   Cell Metabolism

IFN-γ Primes Keratinocytes for HSV-1–Induced Inflammasome Activation

(2016) Gerhard E. Strittmatter et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

(2015) Si Ming Man et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The cell biology of fat expansion

(2015) Joseph M. Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

(2014) Alexander V. Misharin et al.   Cell Reports

SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct

(2013) Christian Schulz et al.   BIOCHEMICAL JOURNAL

Role of interferon-inducible protein 202 (p202) in the regulation of adipogenesis in mouse adipose-derived stem cells

(2013) Haifang Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An Interval of the Obesity QTL Nob3.38 within a QTL Hotspot on Chromosome 1 Modulates Behavioral Phenotypes

(2013) Heike Vogel et al.   PLoS One

Chemokine Expression in Inflamed Adipose Tissue Is Mainly Mediated by NF-κB

(2013) Franck Tourniaire et al.   PLoS One

Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies

(2013) Maeve A. McArdle et al.   Frontiers in Endocrinology

Loss of function of Ifi202b by a microdeletion on chromosome 1 of C57BL/6J mice suppresses 11β-hydroxysteroid dehydrogenase type 1 expression and development of obesity

(2012) Heike Vogel et al.   HUMAN MOLECULAR GENETICS

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Fractalkine Is a Novel Human Adipochemokine Associated With Type 2 Diabetes

(2011) R. Shah et al.   DIABETES

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brown fat as a therapy for obesity and diabetes

(2011) Aaron M Cypess et al.   Current Opinion in Endocrinology Diabetes and Obesity

Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus

(2010) R. Panchanathan et al.   JOURNAL OF IMMUNOLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity

(2009) Huaizhu Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo

(2009) R. Shah et al.   DIABETES

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

T-ing up inflammation in fat

(2009) Carey N. Lumeng et al.   NATURE MEDICINE

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

(2008) O. Osborn et al.   CYTOKINE

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH