Article
Urology & Nephrology
Christoph Wanner, Mark E. Cooper, Odd Erik Johansen, Robert Toto, Julio Rosenstock, Darren K. McGuire, Steven E. Kahn, Egon Pfarr, Sven Schnaidt, Maximilian von Eynatten, Jyothis T. George, Nicholas D. Gollop, Nikolaus Marx, John H. Alexander, Bernard Zinman, Vlado Perkovic
Summary: Individuals with T2D and NRP have a high disease burden. LINA reduces their albuminuria burden and HbA1c, without affecting CV or kidney risk.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Endocrinology & Metabolism
Geert Jan Biessels, Chloe Verhagen, Jolien Janssen, Esther van den Berg, Gudrun Wallenstein, Bernard Zinman, Mark A. Espeland, Odd Erik Johansen
Summary: The study assessed the impact of the DPP-4 inhibitor linagliptin compared to the sulfonylurea glimepiride on accelerated cognitive decline in individuals with type 2 diabetes. Results showed no significant difference in the risk for cognitive decline between the two drugs over a 6.1-year period in people with early type 2 diabetes at elevated cardiovascular risk.
Article
Endocrinology & Metabolism
Ran Abuhasira, Irit Ayalon-Dangur, Neta Zaslavsky, Ronit Koren, Mally Keller, Dror Dicker, Alon Grossman
Summary: The study found no significant difference in time to clinical improvement between hospitalized patients with diabetes and COVID-19 who received linagliptin compared to those who received standard of care.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Dario Giugliano, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito
Summary: The commentary discusses the concepts of removed and residual risks in conditioning the cardiorenal outlook of patients with type 2 diabetes. The study highlights the significant role of newer antihyperglycemic drugs, especially SGLT-2i, in reducing cardiovascular events and the progression of diabetic kidney disease.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Moahad S. Dar, Christoph Wanner, Nikolaus Marx, Anne Pernille Ofstad, Michaela Mattheus, Stefan Kaspers, Sami A. Beg
Summary: This study used the diabetes staging system (DSS) to assess the association between disease stage and mortality rates in type 2 diabetes cardiovascular outcome trials, and found that higher DSS stage was associated with increased rates of all-cause mortality and cardiovascular death.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Steven J. Russell, Roy W. Beck, Edward R. Damiano, Firas H. El-Khatib, Katrina J. Ruedy, Zoey Li, Courtney A. Balliro, Peter Calhoun, R. Paul Wadwa, Bruce Buckingham, Keren Zhou, Mark Daniels, Philip Raskin, Perrin C. White, Jane Lynch, Jeremy Pettus, Irl B. Hirsch, Robin Goland, John B. Buse, Davida Kruger, Nelly Mauras, Andrew Muir, Janet B. McGill, Fran Cogen, Jill Weissberg-Benchell, Jordan S. Sherwood, Luz E. Castellanos, Mallory A. Hillard, Marwa Tuffaha, Melissa S. Putman, Mollie Y. Sands, Gregory Forlenza, Robert Slover, Laurel H. Messer, Erin Cobry, Viral N. Shah, Sarit Polsky, Rayhan Lal, Laya Ekhlaspour, Michael S. Hughes, Marina Basina, Betul Hatipoglu, Leann Olansky, Amrit Bhangoo, Nikta Forghani, Himala Kashmiri, Francoise Sutton, Abha Choudhary, Jimmy Penn, Rabab Jafri, Maria Rayas, Elia Escaname, Catherine Kerr, Ruby Favela-Preza, Schafer Boeder, Subbulaxmi Trikudanathan, Kristen M. Williams, Natasha Leibel, M. Sue Kirkman, Kate Bergamo, Klara R. Klein, Jean M. Dostou, Sriram Machineni, Laura A. Young, Jamie C. Diner, Arti Bhan, J. Kimberly Jones, Matthew Benson, Keisha Bird, Kimberly Englert, Andrea Cedeno, Joe Permuy, Kristina Cossen, Eric Felner, Maamoun Salam, Julie M. Silverstein, Samantha Adamson, Seema Meighan, Andrew Dauber
Summary: In this 13-week, randomized trial, the use of a bionic pancreas was shown to be more effective in reducing glycated hemoglobin levels compared to standard care.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Sanjoy K. Paul, Jonathan E. Shaw, Peter Fenici, Olga Montvida
Summary: This study aimed to explore the risks and mediation effects of developing chronic kidney disease (CKD) and heart failure (HF) in young- and usual-onset type 2 diabetes (T2D) among White Americans (WAs) and African Americans (AAs). The study found that AAs had a higher risk of developing CKD and HF compared to WAs, and CKD had a greater mediation effect on the HF risk difference between ethnicities compared to HF on CKD risk difference.
Article
Endocrinology & Metabolism
Jeremy M. Silverman, Carolyn W. Zhu, James Schmeidler, Pearl G. Lee, Neil B. Alexander, Elizabeth Guerrero-Berroa, Michal S. Beeri, Rebecca K. West, Mary Sano, Martina Nabozny, Martha Karran
Summary: This study compared an adaptive computerized cognitive training intervention with a non-adaptive version in type 2 diabetes patients. Contrary to the hypothesis, only memory showed improvement in the adaptive arm. Post-hoc analysis combining the two arms revealed that computer-related activities may improve diabetes self-management and other outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Katrina B. Dietsche, Sheela N. Magge, Sydney A. Dixon, Faith S. Davis, Andrea Krenek, Aruba Chowdhury, Lilian Mabundo, Michael Stagliano, Amber B. Courville, Shanna Yang, Sara Turner, Hongyi Cai, Kannan Kasturi, Arthur S. Sherman, Joon Ha, Eileen Shouppe, Mary Walter, Peter J. Walter, Kong Y. Chen, Robert J. Brychta, Cody Peer, Yi Zeng, William Figg, Fran Cogen, D. Elizabeth Estrada, Shaji Chacko, Stephanie T. Chung
Summary: This study evaluated the glucose-lowering mechanisms of metformin and liraglutide in African American youth with youth-onset type 2 diabetes. The results showed that both metformin and liraglutide improved glycemic control but did not suppress high rates of gluconeogenesis. Novel therapies targeting beta-cell function and elevated rates of gluconeogenesis are needed for youth-onset type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Froukje Vanweert, Michael Neinast, Edmundo Erazo Tapia, Tineke van de Weijer, Joris Hoeks, Vera B. Schrauwen-Hinderling, Megan C. Blair, Marc R. Bornstein, Matthijs K. C. Hesselink, Patrick Schrauwen, Zoltan Arany, Esther Phielix
Summary: This study used NaPB to lower plasma BCAA levels in patients with T2D and found that it improved peripheral insulin sensitivity, muscle mitochondrial oxidative capacity, and whole-body insulin-stimulated carbohydrate oxidation while reducing plasma BCAA and glucose levels.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Wenying Yang, Xiangjin Xu, Tao Lei, Jianhua Ma, Ling Li, Jie Shen, Binqi Ye, Sandy Zhu, Thomas Meinicke
Summary: The 24-week clinical trial in Chinese patients with T2DM showed that adding linagliptin to insulin therapy was more effective in improving glycemic control compared to placebo, with good tolerability and safety profile. There was no increased risk of hypoglycemia or weight gain observed, indicating that linagliptin could be a beneficial add-on therapy for these patients.
DIABETES OBESITY & METABOLISM
(2021)
Article
Urology & Nephrology
Karsten Heusser, Jens Tank, Andre Diedrich, Annelie Fischer, Tim Heise, Jens Jordan
Summary: This study investigated the effects of SGLT2 inhibitor Empa and HCT on muscle sympathetic nerve activity in patients with type 2 diabetes. The results showed that although both drugs caused volume depletion, Empa had a more significant effect on body weight and glycemic control compared to HCT. Moreover, compared to HCT, Empa led to lower sympathetic nerve activity, indicating that Empa may attenuate sympathetic excitation caused by sodium loss through its specific actions.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Economics
Mi Jun Keng, Jose Leal, Marion Mafham, Louise Bowman, Jane Armitage, Borislava Mihaylova
Summary: By using data from ASCEND, the study assessed the performance of the UKPDS-OM2 model in predicting cardiovascular events and death risks in patients with T2D. The findings showed that the model substantially overpredicted risks of myocardial infarction, stroke, cardiovascular death, and other death, indicating the need for appropriate adjustments or a new model for accurate assessments in contemporary T2D cohorts.
Article
Nutrition & Dietetics
Guanqiong Na, Jing Zhang, Dian Lv, Ping Chen, Xinyue Song, Fenfen Cai, Sicong Zheng, Wenting Wan, Yujuan Shan
Summary: This study aimed to investigate the effects of a 3-month germinated brown rice (GBR) diet on type 2 diabetes mellitus (T2DM) patients and explore the association with serum fatty acids. The results showed that GBR intervention reduced inflammation and significantly decreased blood glucose and lipid levels in T2DM patients. GBR intake also altered fatty acid composition, with increased levels of n-3 polyunsaturated fatty acids and n-3/n-6 PUFA ratio. Moreover, GBR group had higher levels of anti-inflammatory n-3 metabolites and lower levels of pro-inflammatory n-6 metabolites.
CLINICAL NUTRITION
(2023)
Article
Health Care Sciences & Services
Roman Leischik, Katharina Schwarz, Patrick Bank, Ania Brzek, Birgit Dworrak, Markus Strauss, Henning Litwitz, Christian Erik Gerlach
Summary: In patients with type 2 diabetes, walking and e-health (pedometer) activities significantly improve cognitive function and memory. Walking also has benefits in improving body composition and waist circumference. Physical activity is a cost-effective treatment that has preventive and restorative effects on cognitive memory brain function in patients with type 2 diabetes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Geriatrics & Gerontology
Willem S. Eikelboom, Jana Koch, Elizabeth Beattie, Nicola T. Lautenschlager, Colleen Doyle, Esther van den Berg, Janne M. Papma, Kaarin J. Anstey, Moyra E. Mortby
Summary: This study analyzed electronic care notes from residential aged care facilities to investigate the reporting and management of neuropsychiatric symptoms (NPS) by staff. The findings suggest that staff primarily focus on and respond to NPS they perceive as distressing, potentially leading to under-recognition of specific NPS types and a lack of routine assessment and management of underlying causes.
AGING & MENTAL HEALTH
(2023)
Article
Clinical Neurology
S. Franzen, E. van den Berg, Y. Ayhan, D. D. Satoer, O. Turkoglu, G. E. Genc Akpulat, E. G. Visch-Brink, E. A. Scheffers, J. Kranenburg, L. C. Jiskoot, J. van Hemmen, J. M. Papma
Summary: The study aimed to develop and validate a new naming impairment assessment test (NAME) for culturally, educationally, and linguistically diverse individuals. Through a multistage pilot study, a 60-item test with excellent reliability and robust correlations with other language tests was obtained. The study found that patients with AD/mixed dementia obtained lower scores on most items of the NAME test.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychology, Clinical
Sanne Franzen, Esther van den Berg, Willemijn Bossenbroek, Judi Kranenburg, Esther A. Scheffers, Moniek van Hout, Lotte van de Wiel, Miriam Goudsmit, Rozemarijn L. Van Bruchem-Visser, Judy van Hemmen, Lize C. Jiskoot, Janne M. Papma
Summary: This study aimed to develop a new neuropsychological test battery for culturally diverse populations and investigate its feasibility. The results showed that the completion rates of the test battery were generally high, but supplementary tests were administered less frequently. Complicating factors such as suboptimal effort, fatigue, and depression were frequently observed.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Clinical Neurology
Ellen H. Singleton, Jay L. P. Fieldhouse, Jochum J. van 't Hooft, Marta Scarioni, Marie-Paule E. van Engelen, Sietske A. M. Sikkes, Casper de Boer, Diana Bocancea, Esther van den Berg, Philip Scheltens, Wiesje M. van der Flier, Janne M. Papma, Yolande A. L. Pijnenburg, Rik Ossenkoppele
Summary: The study examines the social cognition impairments in patients with behavioural variant of Alzheimer's disease (bvAD) and compares them with patients with behavioural variant frontotemporal dementia (bvFTD) and typical Alzheimer's disease. The findings suggest that patients with bvAD exhibit similar but milder social cognition impairments compared to bvFTD, and greater impairments compared to typical Alzheimer's disease.
Review
Cell Biology
Oksana Sulaieva, Oleksandr Dudin, Pavlina Botsun, Svitlana Pischanska, Valentina Karpachova, Iryna Omelianenko, Mariia Burkatska, Ihor Panko, Tetyana Meged, Yaroslava Solodka, Olena Haidamak, Tetiana Prokopenko, Bogdan Morozov, Taras Rybalchenko, Mykola Dzerzhinsky, Tetyana Falalyeyeva, Nazarii Kobyliak
Summary: The Covid-19 pandemic and ongoing war in Ukraine had a significant impact on cytopathology activities. A retrospective study revealed a decline in testing volumes and a geographic redistribution of cytopathological testing during the war. Despite the challenges, cytopathology practice in Ukraine demonstrated resilience in maintaining healthcare services during the war.
Article
Neurosciences
Willem S. Eikelboom, Esther van den Berg, Michiel Coesmans, Jeannette A. Goudzwaard, Marc Koopmanschap, Najoua Lazaar, Rozemarijn L. van Bruchem-Visser, Jan J. M. Driesen, Tom den Heijer, Susanne Hoogers, Frank Jan de Jong, Francesco Mattace-Raso, Elsbeth C. Thomeer, Suzanne Vrenken, Lilian J. H. M. Vroegindeweij, Sytse U. Zuidema, Ellen H. Singleton, John C. van Swieten, Rik Ossenkoppele, Janne M. Papma
Summary: This study evaluated the effectiveness of the Describe, Investigate, Create, Evaluate (DICE) method in improving neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) at the memory clinic. The results showed that the method did not provide significant benefits at the group level, but individuals with high levels of NPS and NPS-related distress may benefit from this intervention.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Lize C. Jiskoot, Lucy L. Russell, Caroline V. Greaves, Esther van Schaik, Esther van den Berg, Jackie M. Poos, Liset de Boer, Laura Donker Kaat, Harro Seelaar, Yolande A. L. Pijnenburg, John C. van Swieten, Jonathan D. Rohrer
Summary: This study developed and validated an FTD Module to be used in conjunction with the Neuropsychiatric Inventory (NPI) for the assessment of neuropsychiatric symptoms (NPS) in frontotemporal dementia (FTD). The FTD Module improved the diagnostic accuracy of the NPI and has potential for research and therapeutic trials in FTD.
JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Odd Erik Johansen, Delphine Curti, Maximilian von Eynatten, Andreas Rytz, Anirban Lahiry, Frederik Delodder, Gerhard Ufheil, Carmine D'Urzo, Audrey Orengo, Kate Thorne, Jaclyn S. Lerea-Antes
Summary: This study aimed to assess the digestive tolerance and safety of a novel slowly digestible carbohydrate (SDC), oligomalt, in healthy adults. The results showed a dose-dependent effect of high-dose oligomalt compared to maltodextrin on gastrointestinal symptom rating score (GSRS), although the clinical relevance was limited. In conclusion, oligomalt has good safety and tolerance in healthy, normal weight young adults.
Article
Immunology
Pavlo Petakh, Nazarii Kobyliak, Aleksandr Kamyshnyi
Summary: This study analyzed the changes in gut microbiota in COVID-19 patients with Type 2 Diabetes (T2D) using a culture-based method. The results showed differences in gut microbiota composition in T2D patients compared to non-T2D individuals, potentially related to inflammatory dysfunction. This study is important as it provides insights into the role of gut microbiota in COVID-19 patients and may inform future research and treatment strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Geriatrics & Gerontology
Lisanne Tap, Meike W. Vernooij, Frank Wolters, Esther van den Berg, Francesco U. S. Mattace-Raso
Summary: Cerebral small vessel disease (cSVD) is commonly seen in brain imaging of older adults, especially those with cardiovascular disease risk factors. The link between cSVD and cognitive impairment is established, but how and when these vascular changes lead to cognitive decline is still uncertain. Technological advances allow for more accurate identification and quantification of cSVD, which can aid in diagnosing vascular cognitive impairment and identifying individuals at higher risk of cognitive and functional deterioration. This study explores how improved assessment of cSVD through neuropsychological testing, comprehensive geriatric assessment, and modern imaging techniques can enhance diagnosis and prognosis of cognitive impairment. The study also discusses new treatment approaches for cSVD and how these insights can optimize screening and treatment strategies for older adults with cognitive impairment and multiple morbidities.
Article
Medicine, Research & Experimental
Ganna Zaychenko, Igor Belenichev, Valeriia Hnatiuk, Andrii Doroshenko, Oksana Sinitsyna, Oksana Sulaieva, Tetyana Falalyeyeva, Nazarii Kobyliak
Summary: The aim of this study was to determine the effect of resveratrol on joint tissue and its therapeutic mechanism in ovariectomized rats. The results showed that resveratrol prevented weight gain and improved the structure and signaling of cartilage and bone in ovariectomized rats by activating BCL-2 and inhibiting Casp-3 expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Microbiology
Nazarii Kobyliak, Maria Khomenko, Tetyana Falalyeyeva, Alexandra Fedchenko, Oleksii Savchuk, Yuliya Tseyslyer, Liudmyla Ostapchenko
Summary: Type 2 diabetes is a metabolic disease characterized by insulin resistance and beta-cell dysfunction. The gut microbiota has a direct impact on metabolism and metabolic diseases. There is current focus on the effects of probiotics on insulin resistance, glycemic control, and related factors, but there is a lack of evidence for their efficacy on beta-cell function.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Clinical Neurology
Lize C. C. Jiskoot, Esther van den Berg, Sascha A. A. M. Laenen, Jackie M. M. Poos, Lucia A. A. Giannini, Djaina D. D. Satoer, Judy van Hemmen, Yolande A. L. Pijnenburg, Jet M. J. Vonk, Harro Seelaar
Summary: Research suggests that qualitative measures of semantic fluency can provide valuable insights into the progression of different genetic mutations associated with Frontotemporal Dementia (FTD). Specifically, GRN mutation carriers show a decrease in clustering and an increase in cluster size, which is associated with decline in executive function. On the other hand, MAPT mutation carriers display an increase in lexical frequency and a decline in age of acquisition, which is associated with decline in semantic processing. These qualitative measures have the potential to serve as sensitive cognitive biomarkers for the diagnosis and monitoring of FTD.
JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Yurii Penchuk, Maryana Savytska, Nazarii Kobyliak, Danylo Ostapchenko, Igor Kolodiy, Svitlana Onysenko, Olena Tsyryuk, Oleksandr Korotkyi, Fedir Grygoriev, Tetyana Falalyeyeva
Summary: The bacterial lysate of Lactobacillus rhamnosus DV demonstrates antibacterial and antifungal properties when in direct contact with pathogenic agents.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Maryana Savytska, Dmytro Kyriienko, Iuliia Komisarenko, Oleksandr Kovalchuk, Tetyana Falalyeyeva, Nazarii Kobyliak
Summary: This study assessed the impact of probiotic therapy on pancreatic beta-cell function in patients with type 2 diabetes through a double-blind, randomized, placebo-controlled trial. The results showed that probiotic supplementation slightly improved beta-cell function and reduced fasting glucose levels and HbA1c levels. Additionally, probiotic therapy was found to reduce systemic inflammation in patients with type 2 diabetes by lowering pro-inflammatory cytokine levels.
