Review
Engineering, Biomedical
Kai Tang, Meng-Lin Luo, Wei Zhou, Li-Na Niu, Ji-Hua Chen, Fu Wang
Summary: Stable soft tissue integration is crucial for long-term implant stability, preventing peri-implantitis, and protecting underlying bone tissue. Zirconia abutments are preferred over titanium for aesthetic restoration, but achieving soft tissue attachment remains challenging. This review discusses advances in zirconia surface treatment and structural design that can enhance soft tissue integration.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Mariana Brito da Cruz, Joana Faria Marques, Neusa Silva, Sara Madeira, Oscar Carvalho, Filipe Samuel Silva, Joao Carames, Antonio Mata
Summary: This study evaluated the response of periodontal hard tissue and soft tissue cells to microgroove-milled zirconia surfaces. The results showed that the milled microgroove texture did not affect the viability of gingival and bone cells, but it seemed to influence the cellular differentiation of osteoblasts.
Article
Medicine, General & Internal
Akihiro Furuhashi, Yasunori Ayukawa, Ikiru Atsuta, Yunia Dwi Rakhmatia, Kiyoshi Koyano
Summary: This study compared the response of cell lines and soft tissue to titanium, zirconia, and platinum-gold alloy substrates. Titanium and zirconia displayed excellent cell adhesion properties, while the platinum-gold alloy showed poorer adhesion properties.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Ludan Zhang, Yamin Li, Lintian Yuan, Qianyi Zhang, Yuqing Yan, Fan Dong, Jun Tang, Yuguang Wang
Summary: Non-invasive light-based antibacterial therapy has limited efficacy due to poor penetration of light into human tissues, but a wireless-powered blue-light zirconia implant shows promise for treating peri-implant infections. It allows for complete irradiation to complex peri-implant structures and enables timely and controllable anti-infection treatment. The use of blue micro-light emitting diodes as therapeutic light sources effectively kills peri-implant infection-related bacteria without the need for external photosensitive agents.
Article
Chemistry, Physical
Masfueh Razali, Wen Lin Chai, Ros Anita Omar, Wei Cheong Ngeow
Summary: The study aimed to investigate the effect of photofunctionalization on the soft-tissue contour at the interface of different abutment materials. The results showed that UV treatment of the materials led to the formation of more non-pocket tissue types. Among all the tested materials, yttria-stabilized zirconia exhibited higher scores for the non-pocket type of soft tissue contour. This study highlights the importance of evaluating the biological endpoints of implant surface modifications using the 3D-OMM.
Article
Biochemistry & Molecular Biology
Masfueh Razali, Wei Cheong Ngeow, Ros Anita Omar, Wen Lin Chai
Summary: This study demonstrated that surface modification of implant abutment materials through photofunctionalization can enhance epithelial and connective tissue attachment around zirconia implant abutments, forming a biological seal. YSZ showed the lowest permeability among all materials, indicating superior biological seal formation.
Article
Dentistry, Oral Surgery & Medicine
Chaoling Zheng, Shimin Wang, Hongqiang Ye, Yunsong Liu, Wenjie Hu, Yongsheng Zhou
Summary: The study aimed to evaluate clinical outcomes and soft tissue changes following implant restoration with or without a pre-implantation free gingival graft (FGG). Clinical parameters were slightly lower in the FGG group, although not significantly different from the Control group. Peri-implant soft tissue changes were significantly less in the FGG group compared to the Control group, indicating that FGG may help maintain soft tissue. However, the impact on implant health over 12 months was not significant.
Article
Engineering, Biomedical
John Xiong, Catherine M. Miller, Dileep Sharma
Summary: The study examined the safety of bergenin, a traditional medicine, on human gingival fibroblasts cultured on acid-etched zirconia implant surfaces. Bergenin at different concentrations did not have a significant effect on cellular responses, suggesting its potential as a safe pharmacological agent for peri-implant inflammatory diseases.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biology
Marco Aoqi Rausch, Hassan Shokoohi-Tabrizi, Christian Wehner, Benjamin E. Pippenger, Raphael S. Wagner, Christian Ulm, Andreas Moritz, Jiang Chen, Oleh Andrukhov
Summary: The translation discusses the comparison between zirconia and titanium dental implants in relation to the behavior of primary human gingival fibroblasts. The study found that surface roughness had a more significant impact on cell behavior and gene expression compared to the implant material. No clear advantage of zirconia over titanium was observed, highlighting the importance of surface structure in soft tissue healing.
Article
Medicine, General & Internal
Martina Stefanini, Matteo Sangiorgi, Diego Bianchelli, Pietro Bellone, Federico Gelpi, Daniele De Santis, Giovanni Zucchelli
Summary: This article describes a novel approach that combines muco-gingival, regenerative, and prosthetics concepts for immediate implant insertion. By using specific surgical techniques and materials, this approach allows for soft- and hard-tissue augmentation, resulting in good aesthetic outcomes and high patient satisfaction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Dentistry, Oral Surgery & Medicine
Lorenzo Tavelli, Shayan Barootchi, Gustavo Avila-Ortiz, Istvan A. Urban, William Giannobile, Hom-Lay Wang
Summary: This study analyzed the efficacy of soft tissue augmentation procedures aimed at modifying the peri-implant soft tissue phenotype and their impact on peri-implant health. Results showed that using bilaminar techniques combined with soft tissue grafts resulted in a significant increase in mucosal thickness, while apically positioned flap techniques combined with free gingival grafts showed a significant increase in keratinized mucosa width.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Maria Elisa Galarraga-Vinueza, Lorenzo Tavelli
Summary: This article reviews the importance of soft tissue grafting in preventing and treating peri-implant diseases. It explores the inflammatory mechanisms in the peri-implant soft tissue, examines the impact of different structural components on peri-implant health, and evaluates the clinical indications and expected outcomes of soft tissue augmentation procedures. The review provides valuable insights and recommendations for the comprehensive treatment of peri-implant disease.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Martina Stefanini, Matteo Marzadori, Matteo Sangiorgi, Alexandra Rendon, Tiziano Testori, Giovanni Zucchelli
Summary: This paper discusses the possible factors contributing to inadequate quality, quantity, or aesthetics of peri-implant soft tissues and provides clinical insights on surgical soft tissue management to prevent or treat complications that may affect the status of the peri-implant soft tissues. Mastering the learning curve and understanding the limitations of each technique are crucial to avoid treatment failures and patient dissatisfaction.
PERIODONTOLOGY 2000
(2023)
Article
Engineering, Biomedical
Yosuke Asami, Hodaka Sasaki, Atsuro Harada, Kiyotoshi Hanazawa, Takafumi Kobayashi, Gentaro Mori, Yasutomo Yajima
Summary: During wound healing, the gene expression of PIST-specific inflammatory markers was higher in PIST compared to OMT, but there were no significant differences in the expression of standard inflammatory markers. The molecule CXCL2 was locally expressed at the implant-connective tissue interface, with immune cells closely matching its expression pattern. In PIST, seven of the PIST-specific inflammatory markers were specifically and strongly expressed during wound healing and their expression continued until the end of healing, establishing a unique defense mechanism not seen in OMT or PT.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Dentistry, Oral Surgery & Medicine
Frederic Dethier, Miljana Bacevic, Geoffrey Lecloux, Laurence Seidel, Eric Rompen, France Lambert
Summary: This study evaluated the soft tissue integration of four different transmucosal materials in a minipig model and examined the peri-implant bone remodeling. The results showed that all tested materials allowed soft tissue integration, characterized by a long junctional epithelium and a short connective tissue attachment. Additionally, the peri-implant bone remodeling was similar in all four groups.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2022)
