Article
Multidisciplinary Sciences
Jinrun Dong, Yuxian Lu, Yang Xu, Fanfan Chen, Jinmei Yang, Yuang Chen, Jiandong Feng
Summary: Optical imaging of single-molecule electrochemical reactions in aqueous solution enables super-resolution electrochemiluminescence microscopy, providing high spatiotemporal resolution for monitoring adhesion dynamics of live cells. Single-molecule methods go beyond ensemble averages and reveal statistical distribution of reaction positions, pathways, and dynamics, advancing fundamental understanding of electrochemical reactions and proving useful for bioassays and cell-imaging applications.
Article
Chemistry, Physical
Christine A. Carlson, Xavier S. Udad, Quintus Owen, Alaknanda P. Amin-Patel, Woo-Jin Chang, Jorg C. Woehl
Summary: This study reports the reversible and tunable trapping of single DNA molecules and other charged microparticles and nanoparticles in aqueous solution using a DC corral trap setup. The trap shows the ability to stably confine charged objects at the nanoscale, control trap stiffness with applied voltage, and simultaneously trap multiple objects.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Maoning Wang, Jieyi Zhang, Adila Adijiang, Xueyan Zhao, Min Tan, Xiaona Xu, Surong Zhang, Wei Zhang, Xinyue Zhang, Haoyu Wang, Dong Xiang
Summary: The manipulation of single molecules at room temperature still faces challenges, but by utilizing scanning tunneling microscope break junction (STM-BJ) techniques and localized surface plasmon (LSP)-assisted trapping, adjustable plasmonic nanogaps can be created and the formation of molecular junctions can be characterized.
Review
Chemistry, Multidisciplinary
Biao-Feng Zeng, Yu-Ling Zou, Gan Wang, Wenjing Hong, Zhong-Qun Tian, Yang Yang
Summary: Recent advances in single-molecule electronics have opened up new opportunities to investigate single-molecule chemistry. The focus has shifted towards quantitative analysis of the physical and chemical behavior of single molecules, including dynamic molecular configurations, redox states, single-molecule reactions, single-molecule sensing, and molecular adsorption behaviors.
Article
Chemistry, Multidisciplinary
Maria Bespalova, Robin Oz, Fredrik Westerlund, Madhavi Krishnan
Summary: This study demonstrates the use of surfaces coated with charged lipid bilayers as a system with tunable surface properties for molecular electrometry experiments, and explores the relevance of lipid bilayer formation and wetting dynamics on nanostructured surfaces.
Article
Chemistry, Multidisciplinary
Yuna Bae, Min Young Ha, Ki-Taek Bang, Sanghee Yang, Sung Yun Kang, Joodeok Kim, Jongbaek Sung, Sungsu Kang, Dohun Kang, Won Bo Lee, Tae-Lim Choi, Jungwon Park
Summary: This paper utilizes liquid-phase transmission electron microscopy to track the real-time dynamics of single-chain polymers, revealing the conformational characteristics of these polymers and their dependence on intrachain interactions and environmental factors.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Olessya Yukhnovets, Henning Hofig, Nuno Bustorff, Alexandros Katranidis, Jorg Fitter
Summary: For single-molecule studies in solution, very low concentrations of dye-labelled molecules are needed to achieve single-molecule sensitivity. Specific demands on surface passivation are required to ensure stability of molecule concentration over a period of several hours. Diffusion rate and absolute molecule concentrations are important for controlling the number of molecules in the detection volume.
Review
Chemistry, Physical
Joshua D. Kolbow, Nathan C. Lindquist, Christopher T. Ertsgaard, Daehan Yoo, Sang-Hyun Oh
Summary: Optical tweezers were developed in 1970 by Arthur Ashkin for manipulation of micron-sized particles, and have since evolved into nano-optical tweezers and holographic tweezers. These new technologies have enabled trapping of single molecules and various studies on them.
Article
Chemistry, Multidisciplinary
Biao-Feng Zeng, Ran Deng, Yu-Ling Zou, Chun-An Huo, Jing-Yu Wang, Wei-Ming Yang, Qing-Man Liang, Sheng-Jie Qiu, Anni Feng, Jia Shi, Wenjing Hong, Zhilin Yang, Zhong-Qun Tian, Yang Yang
Summary: This study proposes an affordable solution for manipulating single chemical and biological molecules in nanoscience. By using an adjustable plasmonic optical nanogap and single-molecule conductance measurement, the direct trapping and in situ sensing of single molecules with unprecedented size down to 5 angstrom in solution is achieved. Theoretical simulations show that high enhancement factor local fields are generated at small nanogaps, resulting in optical forces large enough to suppress Brownian motion and trap sub-1 nm length molecules.
Article
Chemistry, Physical
Lingzhi Tu, Hongguang Liu
Summary: Ignoring the molecular packing effects can lead to significant deviations in charge transfer rate and energy, impacting the performance of organic semiconductor materials.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Albert C. Aragones, Katrin F. Domke
Summary: The study introduces a plasmon-supported break-junction (PBJ) platform to significantly increase the lifetime of 1,4-benzenedithiol (BDT) molecular junctions without the need for chemical modification. Experimental results show that this platform can enhance the survival period of single molecule structures and pave the way for advancements in molecular electronics.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Article
Chemistry, Analytical
Javier Sabines-Chesterking, Ivan A. Burenkov, Sergey V. Polyakov
Summary: Fluorescent biomarkers are widely used for detecting trace amounts of target molecules in heterogeneous cell populations. However, it is challenging to detect these biomarkers in a flow cytometer due to their low abundance. In this study, we propose a framework based on quantum measurements and single-photon detection to establish a detection baseline for individual emitters and enable absolute calibration of a flow cytometer. We demonstrate accurate identification of rare events with occurrence rates below 10-5 even at modest signal-to-noise ratios, which could potentially facilitate early disease diagnostics and post-disease monitoring.
Article
Multidisciplinary Sciences
Carl W. Fuller, Pius S. Padayatti, Hadi Abderrahim, Lisa Adamiak, Nolan Alagar, Nagaraj Ananthapadmanabhan, Jihye Baek, Sarat Chinni, Chulmin Choi, Kevin J. Delaney, Rich Dubielzig, Julie Frkanec, Chris Garcia, Calvin Gardner, Daniel Gebhardt, Tim Geiser, Zachariah Gutierrez, Drew A. Hall, Andrew P. Hodges, Guangyuan Hou, Sonal Jain, Teresa Jones, Raymond Lobaton, Zsolt Majzik, Allen Marte, Prateek Mohan, Paul Mola, Paul Mudondo, James Mullinix, Thuan Nguyen, Frederick Ollinger, Sarah Orr, Yuxuan Ouyang, Paul Pan, Namseok Park, David Porras, Keshav Prabhu, Cassandra Reese, Travers Ruel, Trevor Sauerbrey, Jaymie R. Sawyer, Prem Sinha, Jacky Tu, A. G. Venkatesh, Sushmitha VijayKumar, Le Zheng, Sungho Jin, James M. Tour, George M. Church, Paul W. Mola, Barry Merriman
Summary: This study presents an advanced molecular electronics chip that utilizes molecular circuit elements as general-purpose single-molecule sensors. The chip digitizes the electrical characteristics of single-molecule interactions with probe molecules, enabling high-resolution measurements of interaction kinetics. This scalable platform offers broad applicability for studying various molecular interactions in a massively parallel fashion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Qi Hao, Zhaohui Peng, Jiawei Wang, Xingce Fan, Guoqun Li, Xing Zhao, Libo Ma, Teng Qiu, Oliver G. Schmidt
Summary: Polarization-selective Raman measurement is proposed as a reliable method for single-molecule surface-enhanced Raman scattering (SMSERS) verification, featuring rapid acquisition of SMSERS events and liberal requirements for analyte concentration. This method efficiently sorts out multiple SMSERS events from a large-scale plasmonic dimer array and allows identification of mixed SMSERS events.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Nathaniel B. Vilas, Christian Hallas, Loic Anderegg, Paige Robichaud, Andrew Winnicki, Debayan Mitra, John M. Doyle
Summary: In this study, the successful magneto-optical trapping of a polyatomic molecule, calcium monohydroxide (CaOH), demonstrates the feasibility and practicality of laser cooling and trapping for polyatomic species. This achievement has significant implications for various applications in quantum science.