Article
Biology
Ya-tang Li, Markus Meister
Summary: The superior colliculus in the brain is a crucial visual processing station that receives input from various types of retinal ganglion cells. Through recording mouse superficial SC neurons, we identified 24 functional types using an unsupervised clustering algorithm. These types can be grouped into two categories: one that responds similarly to retinal ganglion cells and another with more diverse and specialized stimulus selectivity. Cells of the same functional type tend to cluster together in anatomical space, and the visual representation in the SC has lower dimensionality compared to the retina, suggesting a sifting process along the visual pathway.
Article
Neurosciences
Hui Chen, Elise L. Savier, Victor J. DePiero, Jianhua Cang
Summary: Through studying the mouse superior colliculus, it was found that direction-selective neurons are not organized into stereotypical columns, but rather exist in clusters. This phenomenon is not affected by factors such as animal state, SC depth, research technique, and stimulus type, challenging recent reports on region-specific organizations in the mouse SC.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Dario Campagner, Ruben Vale, Yu Lin Tan, Panagiota Iordanidou, Oriol Pavon Arocas, Federico Claudi, A. Vanessa Stempel, Sepiedeh Keshavarzi, Rasmus S. Petersen, Troy W. Margrie, Tiago Branco
Summary: This study reveals that the mouse retrosplenial cortex (RSP) and superior colliculus (SC) form a circuit that encodes the shelter-direction vector and is crucial for accurately orienting to shelter during escape. The circuit incorporates spatial information to execute rapid flights along the most efficient route to shelter.
Article
Neurosciences
Faraj L. Haddad, Maryam Ghahremani, Cleusa De Oliveira, Ella E. Doornaert, Kevin D. Johnston, Stefan Everling, Susanne Schmid
Summary: This study successfully measured changes in spatial attention and orienting responses by developing a novel touchscreen task. Results show that unilateral inactivation of the superior colliculus may lead to increased turning angle, bias towards the ipsilateral side, and a leftward shift of the respective psychometric function.
Article
Neurosciences
Joshua M. Brenner, Riccardo Beltramo, Charles R. Gerfen, Sarah Ruediger, Massimo Scanziani
Summary: It has been believed that the cortical responses to visual stimuli rely on the geniculo-striate pathway. However, recent research has shown that the postrhinal cortex (POR), a visual cortical area, actually depends on the tecto-thalamic pathway via the superior colliculus (SC). This discovery suggests the existence of a wider system of tecto-thalamic cortical visual areas. The lateral visual areas, in particular, show the strongest dependence on the SC. This system is driven by a specific genetically defined cell type that connects the SC to the pulvinar thalamic nucleus. Furthermore, the SC-dependent cortices can distinguish self-generated visual motion from externally generated motion. Therefore, these lateral visual areas form a system that relies on the tecto-thalamic pathway and plays a crucial role in processing visual motion as animals move through their environment.
Article
Oncology
Sonia Iyer, Shuang Zhang, Simge Yucel, Heiko Horn, Sean G. Smith, Ferenc Reinhardt, Esmee Hoefsmit, Bimarzhan Assatova, Julia Casado, Marie-Charlotte Meinsohn, M. Inmaculada Barrasa, George W. Bell, Fernando Perez-Villatoro, Kaisa Huhtinen, Johanna Hynninen, Jaana Oikkonen, Pamoda M. Galhenage, Shailja Pathania, Paula T. Hammond, Benjamin G. Neel, Anniina Farkkila, David Pepin, Robert A. Weinberg
Summary: The study developed a series of mouse models carrying genotypes of human high-grade serous tubo-ovarian carcinomas (HGSC) that can grow in syngeneic immunocompetent hosts, recapitulating human disease characteristics, including genotype-driven responses to treatment. The research identified follistatin as a driver of resistance to checkpoint inhibitors.
Article
Neurosciences
Qingpeng Yu, Hang Fu, Gang Wang, Jiayi Zhang, Biao Yan
Summary: The study found that visual experience can potentiate spontaneous activity in mouse superior colliculus neurons, with feature selectivity for direction and orientation. By stimulating retinal ganglion cells or optogenetically activating parvalbumin neurons, this potentiation can be attenuated or blocked.
NEUROSCIENCE BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Tadashi Isa, Emmanuel Marquez-Legorreta, Sten Grillner, Ethan K. Scott
Summary: The superior colliculus, or tectum, is responsible for registering events in the surrounding space through various sensory modalities. It forms maps of the space and positions of stimuli, with different sensory inputs arranged in layers. Outputs from the tectum can directly influence motor circuits or be relayed to cortical areas through the thalamus to control behavior.
Article
Chemistry, Multidisciplinary
Chong Duan, Jing-Jing Hu, Rui Liu, Jun Dai, Mojie Duan, Lizhen Yuan, Fan Xia, Xiaoding Lou
Summary: Researchers focused on different spatial arrangements of modular-agent probes and designed two MAPs to compare their specificity and toxicity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Lloyd D. Fricker, Alexandre K. Tashima, Amanda K. Fakira, Ute Hochgeschwender, William C. Wetsel, Lakshmi A. Devi
Summary: This study utilized a conditional disruption mouse model of the Cpe gene to identify specific forms of neuropeptides through peptidomics, revealing the specific forms of neuropeptides in cells with disrupted Cpe gene.
CELL CHEMICAL BIOLOGY
(2021)
Article
Neurosciences
Yufei Si, Shinya Ito, Alan M. Litke, David A. Feldheim
Summary: This study investigates the lack of frontal auditory receptive fields (RFs) in C57BL/6 mice and finds that they lack the ability to detect high-frequency spectral cues. The researchers also demonstrate that crossing and gene introduction can improve the auditory deficits in C57BL/6 mice.
Article
Neurosciences
Masatoshi Kasai, Tadashi Isa
Summary: This study found that changes in brain states can affect the selectivity of SC neurons and the organization of neuronal populations. Under isoflurane anesthesia, orientation selectivity increased and more orientation-selective cells were observed, while the proportions of direction-selective cells were similar in both conditions. Additionally, neurons with similar preferences located closer together and showed enhanced cluster-like spatial patterns.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Baiwei Liu, Anna C. Nobre, Freek van Ede
Summary: The study found that covert visual spatial attention can modulate neural activity and bias the direction of microsaccades. These two markers co-vary but microsaccades are not necessary for neural modulation by attention to occur.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Shuang Zhang, Sonia Iyer, Hao Ran, Igor Dolgalev, Shengqing Gu, Wei Wei, Connor J. R. Foster, Cynthia A. Loomis, Narciso Olvera, Fanny Dao, Douglas A. Levine, Robert A. Weinberg, Benjamin G. Neel
Summary: Genetically informed, immunocompetent tumor models are crucial for evaluating conventional, targeted, and immune therapies. By engineering mouse fallopian tube organoids, researchers were able to study the effects of specific mutations found in high-grade serous tubo-ovarian cancer (HGSC) models, leading to the development of effective combination treatments for different genetic subgroups of HGSC. These findings highlight the importance of genotype-informed, syngeneic organoid models for understanding tumor biology and therapeutic responses.
Review
Neurosciences
Thomas Wheatcroft, Aman B. Saleem, Samuel G. Solomon
Summary: The superior colliculus (SC) is a highly conserved area in the mammalian midbrain that is involved in the organization and control of behavior. Recent studies in mice have provided anatomical data and experimental evidence to understand the roles of different cells within SC in simple behaviors. The functional organization of SC can be explained by three distinct circuits supporting three classes of simple behaviors- arrest, turning towards, and the triggering of escape or capture.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Biochemistry & Molecular Biology
Ming-Shih Hwang, Jerome Boulanger, Jonathan D. Howe, Anna Albecka, Mathias Pasche, Leila Muresan, Yorgo Modis
Article
Neurosciences
Stefano L. Giandomenico, Susanna B. Mierau, George M. Gibbons, Lea M. D. Wenger, Laura Masullo, Timothy Sit, Magdalena Sutcliffe, Jerome Boulanger, Marco Tripodi, Emmanuel Derivery, Ole Paulsen, Andras Lakatos, Madeline A. Lancaster
NATURE NEUROSCIENCE
(2019)
Editorial Material
Neurosciences
Letizia Mariotti, Marco Tripodi
Editorial Material
Biochemistry & Molecular Biology
Laura Masullo, Marco Tripodi
Editorial Material
Neurosciences
Ana Gonzalez-Rueda, Marco Tripodi
TRENDS IN NEUROSCIENCES
(2019)
Article
Cell Biology
Natalia Gomez-Navarro, Alejandro Melero, Xiao-Han Li, Jerome Boulanger, Wanda Kukulski, Elizabeth A. Miller
JOURNAL OF CELL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Girish R. Mali, Ferdos Abid Ali, Clinton K. Lau, Farida Begum, Jerome Boulanger, Jonathan D. Howe, Zhuo A. Chen, Juri Rappsilber, Mark Skehel, Andrew P. Carter
Summary: The protein Shulin binds to ODAs in the cytoplasm, inhibits their motor activity, stabilizes their compact form, and facilitates their delivery to the cilia, providing a molecular explanation for the process.
Article
Multidisciplinary Sciences
Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Letizia Mariotti, Tullio Pozzan, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato, Micaela Zonta
Summary: This study reveals that decreased calcium activity in astrocytes is associated with memory loss in a mouse model of Alzheimer's disease. Overexpression of STIM1 can restore calcium signaling and synaptic plasticity in astrocytes.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Elisa Greotti, Ilaria Fortunati, Diana Pendin, Camilla Ferrante, Luisa Galla, Lorena Zentilin, Mauro Giacca, Nina Kaludercic, Moises Di Sante, Letizia Mariotti, Annamaria Lia, Marta Gomez-Gonzalo, Michele Sessolo, Fabio Di Lisa, Giorgio Carmignoto, Renato Bozio, Tullio Pozzan
Article
Multidisciplinary Sciences
Fei Kang, Mengxuan Zhou, Xiaoshuai Huang, Junchao Fang, Lisi Wei, Jerome Boulanger, Zengzhen Liu, Jean Salamero, Yanmei Liu, Liangyi Chen
SCIENTIFIC REPORTS
(2019)