Article
Cell Biology
Lindsay E. Wu, Corrine E. Fiveash, Nicholas L. Bentley, Myung-Jin Kang, Hemna Govindaraju, Jayne A. Barbour, Brendan P. Wilkins, Sarah E. Hancock, Romanthi Madawala, Abhijit Das, Hassina Massudi, Catherine Li, Lynn-Jee Kim, Ashley S. A. Wong, Maria B. Marinova, Ghazal Sultani, Abhirup Das, Neil A. Youngson, David G. Le Couteur, David A. Sinclair, Nigel Turner
Summary: The NAD+-dependent deacylase family of sirtuin enzymes, including SIRT2, play important roles in biological aging, late-life health, and overall lifespan. However, the role of SIRT2 has been less clear. Previous studies showed that transgenic overexpression of SIRT2 can improve health and increase lifespan in a progeria model. In this study, the researchers tested whether SIRT2 overexpression would impact the overall health and lifespan of mice on a nonprogeroid, wild-type background. They found that SIRT2 overexpression did not have an additional impact on health or lifespan in these mice. Biochemical studies also revealed changes in brain metabolites in SIRT2 overexpressing mice, but these changes did not translate into functional differences.
Article
Multidisciplinary Sciences
Maria Razzoli, Kewir Nyuyki-Dufe, Brian H. Chen, Alessandro Bartolomucci
Summary: Sustained life stress and low socioeconomic status are major causes of aging-related diseases and decreased life expectancy. However, there are very few studies that address the long-term consequences of social stress on aging.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Thais R. Peclat, Katie L. Thompson, Gina M. Warner, Claudia C. S. Chini, Mariana G. Tarrago, Delaram Z. Mazdeh, Chunlian Zhang, Jose Zavala-Solorio, Ganesh Kolumam, Yao Liang Wong, Robert L. Cohen, Eduardo N. Chini
Summary: Inhibiting CD38 enzyme can prolong the lifespan and healthspan of aged mice, improve exercise performance, endurance, and metabolic function, with differences observed between sexes.
Review
Nutrition & Dietetics
So-Hyun Park, Da-Hye Lee, Dae-Hee Lee, Chang Hwa Jung
Summary: Age is a risk factor for diseases, and prolonging healthspan is important. Dietary restriction, such as calorie restriction and fasting, has received attention for its potential to extend lifespan and healthspan. However, scientific evidence on specific foods' effects on lifespan and healthspan is lacking. This study aims to synthesize recent research on the effects of foods and phytochemicals on lifespan and healthspan.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Yiling Yang, Wenbin Wang, Kefeng Liu, Jie Zhao
Summary: This study developed an antioxidant nanosystem (SOD@MSN) by immobilizing SOD on mesoporous silica nanoparticles (MSNs) and conducted anti-aging experiments using the nematode model. The results showed that SOD@MSN could be effectively internalized by the nematode and protect it against external stress, thus extending its lifespan and healthspan.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xin-Xin Zhang, Shi-Hao He, Xu Liang, Wei Li, Tian-Fang Li, Dai-Feng Li
Summary: Osteoarthritis is a chronic joint disease characterized by cartilage destruction, with aging playing a key role. Current treatments are palliative, and there is a need for disease-modifying drugs. Cellular senescence, synovial inflammation, and epigenetic changes may contribute to its pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Tobias Nespital, Brit Neuhaus, Andrea Mesaros, Andre Pahl, Linda Partridge
Summary: Lithium shows a potential positive impact on health span in mice within a tolerable dose range, with caution needed for overdosing to avoid organ health issues.
Review
Geriatrics & Gerontology
Saghi Hakimi Naeini, Laleh Mavaddatiyan, Zahra Rashid Kalkhoran, Soroush Taherkhani, Mahmood Talkhabi
Summary: Aging is a natural process that causes functional decline in cells and tissues, increasing the risk of disease and death. Efforts have been made to control aging and increase lifespan and healthspan, leading to the discovery of drugs like rapamycin and metformin. Alpha-ketoglutarate (AKG) is a metabolite that shows potential as an anti-aging compound, improving longevity and reproductive health. It plays a crucial role in various cellular functions and exerts its effects through different mechanisms. This article summarizes recent studies on AKG-related lifespan and discusses its promises and limitations for delaying aging and other potential applications.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Cell Biology
Aleksandra Dabrowska, Juhi Kumar, Charalampos Rallis
Summary: Cellular and animal models have played a crucial role in understanding the relationship between diet, nutrient-response signaling pathways, and lifespan regulation. Recent advancements in drug treatments, mutagenesis, and high-throughput screens have provided valuable insights into cellular metabolism, development, and aging. Scientists are now focusing on characterizing growth and stress pathways to identify interventions for healthy aging and age-related diseases.
Article
Biochemistry & Molecular Biology
Lindsey H. Burton, Maryam F. Afzali, Lauren B. Radakovich, Margaret A. Campbell, Lauren A. Culver, Christine S. Olver, Kelly S. Santangelo
Summary: The study demonstrated that pharmacologic iron chelation with deferoxamine reduced iron levels and delayed the progression of primary osteoarthritis in an animal model. Reduction of iron content alleviated cartilage lesions, decreased chondrocyte hypocellularity, enhanced expression of anti-apoptotic genes, and decreased expression of matrix-degrading enzymes.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Orthopedics
Shannon K. Walsh, Rikin Soni, Lisa M. Arendt, Melissa C. Skala, Corinne R. Henak
Summary: The study revealed age-dependent metabolic activity in cartilage, with metabolic dysfunction impacting gene expression related to tissue maintenance. Glycolysis, oxidative phosphorylation activity, and optical redox ratio were positively correlated with severity of cartilage damage.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Qianqian Wang, Junhui Zhang, Jiachen Zhuang, Fei Shen, Minjie Zhao, Juan Du, Peng Yu, Hao Zhong, Fengqin Feng
Summary: This study found that supplementation with soft-shelled turtle peptides could prolong the lifespan and healthspan of fruit flies. It improved antioxidant, starvation, and heat stress abilities, and achieved anti-aging effects by enhancing autophagy and reducing oxidative stress through the downregulation of the target of rapamycin signaling pathway.
Review
Geriatrics & Gerontology
Shital Wakale, Xiaoxin Wu, Yogita Sonar, Antonia Sun, Xiwei Fan, Ross Crawford, Indira Prasadam
Summary: Osteoarthritis (OA) is a common degenerative joint disease that significantly impairs the physical function of the elderly population. This review focuses on the age-related changes in chondrocytes and their impact on OA development, including senescence, mitochondrial dysfunction, epigenetic modifications, and decreased growth factor response. These changes also extend to the matrix, subchondral bone, and synovium. Understanding these alterations provides potential therapeutic approaches for OA treatment.
Article
Pharmacology & Pharmacy
Qihang Hou, Jingxi Huang, Lihua Zhao, Xianjie Pan, Chaoyong Liao, Qiuyu Jiang, Jiaqi Lei, Fangshen Guo, Jian Cui, Yuming Guo, Bingkun Zhang
Summary: Age-related gastrointestinal decline contributes to whole-organism frailty and mortality. Dietary genistein promotes a healthier and longer life in aging mice by decreasing systemic inflammatory cytokines levels and ameliorating gut dysfunctions. Genistein-associated alteration in gut microbiota increases Lachnospira abundance and short-chain fatty acid production, rejuvenating the aging gut and extending the lifespan of progeroid mice.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiaze Tang, Anji Ju, Boya Li, Shaosen Zhang, Yuanchao Gong, Boyuan Ma, Yi Jiang, Hongyi Liu, Yan Fu, Yongzhang Luo
Summary: The injection of exogenous recombinant mouse serum albumin (rMSA) reduced protein damages in mice, improving their healthspan and lifespan significantly. The young and undamaged rMSA used in the study showed better results than endogenous serum albumin, leading to potential further improvements in healthspan and lifespan.