Integration of morphological preprocessing and fractal based feature extraction with recursive feature elimination for skin lesion types classification

Background and objective: Skin cancer is the commonest form of cancer in the worldwide population. Non-invasive and non-contact imaging modalities are being used for the screening of melanoma and other cutaneous malignancies to endorse early detection and prevention of the disease. Traditionally it has been a problem for medical personnel to differentiate melanoma, dysplastic nevi and basal cell carcinoma (BCC) diseases from one another due to the confusing appearance and similarity in the characteristics of the pigmented lesions. The paper reports an integrated method developed for identifying these skin diseases from the dermoscopic images. Methods: The proposed integrated computer-aided method has been employed for the identification of each of these diseases using recursive feature elimination (RFE) based layered structured multiclass image classification technique. Prior to the classification, different quantitative features have been extracted by analyzing the shape, the border irregularity, the texture and the color of the skin lesions, using different image processing tools. Primarily, a combination of gray level co-occurrence matrix (GLCM) and a proposed fractal-based regional texture analysis (FRTA) algorithm has been used for the quantification of textural information. The performance of the framework has been evaluated using a layered structure classification model using support vector machine (SVM) classifier with radial basis function (RBF). Results: The performance of the morphological skin lesion segmentation algorithm has been evaluated by estimating the pixel level sensitivity (Sen) of 0.9172, 0.9788 specificity (Spec), 0.9521 accuracy (ACU), along with the image similarity measuring indices as Jaccard similarity index USI) of 0.8562 and Dice similarity coefficient (DSC) of 0.9142 with respect to the corresponding ground truth (GT) images. The quantitative features extracted from the proposed feature extraction algorithms have been employed for the proposed multi-class skin disease identification. The proposed layered structure identifies all the three classes of skin diseases with a highly acceptable classification accuracy of 98.99%, 97.54% and 99.65% for melanoma, dysplastic nevi and BCC respectively. Conclusion: To overcome the difficulties of proper diagnosis of diseases based on visual evaluation, the proposed integrated system plays an important role by quantifying the effective features and identifying the diseases with higher degree of accuracy. This combined approach of quantitative and qualitative analysis not only increases the diagnostic accuracy, but also provides some important information not obtainable from qualitative assessment alone. (C) 2019 Elsevier B.V. All rights reserved.