The concept of dual roles design in clean organic preparation

Herein we summarized some clean preparation examples to emphasize the concept of dual roles design (or named as two birds one stone strategy) in green and sustainable chemistry. In those examples, the reactants and/or solvent play dual roles rendering a cleaner organic preparation process. Consequently, both the chemical waste and manufacturing cost could be reduced. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.