Review
Chemistry, Multidisciplinary
Myuto Kashihara, Yoshiaki Nakao
Summary: Cross-coupling reactions using nitroarenes as electrophiles have gained attention due to their ease of accessibility and potential advantages over haloarenes. Recent research has focused on developing new catalyst systems and reaction conditions to improve the efficiency and practicality of these reactions, with promising results in diversifying bond-forming reactions and reducing catalyst loading. Research in this field is expected to continue growing as the utility of nitroarenes in organic synthesis is reevaluated.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Ji-Jun Chen, Jia-Yong Zhang, Jia-Heng Fang, Xuan-Yi Du, Hai-Dong Xia, Bin Cheng, Nan Li, Zhang-Long Yu, Jun-Qian Bian, Fu-Li Wang, Jing-Jing Zheng, Wei-Long Liu, Qiang-Shuai Gu, Zhong-Liang Li, Xin-Yuan Liu
Summary: By using appropriate ligand selection, a copper catalyzed enantioconvergent radical C(sp(3))-N cross-coupling reaction between racemic alkyl halides and (hetero)aromatic amines has been achieved under ambient conditions. The method allows for the synthesis of enantioenriched N-alkyl (hetero)aromatic amines, and exhibits good functional group compatibility and broad substrate scope for activated racemic secondary/tertiary alkyl bromides/chlorides and (hetero)aromatic amines.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Qingyao Li, Peng Dai, Haidi Tang, Muliang Zhang, Jie Wu
Summary: The significance of amide functional groups in organic synthesis and pharmaceutical studies is widely recognized. However, current synthesis methods often involve the use of stoichiometric activating reagents and metallic reductants, leading to the production of toxic chemical waste. In this study, a photo-mediated hydrogen atom transfer catalysis is developed for direct reductive amidation reaction, which avoids the use of metallic reductants and toxic chemical waste. The method provides an efficient and practical strategy for the synthesis of amides.
Article
Multidisciplinary Sciences
Shuaishuai Wang, Tingrui Li, Chengyihan Gu, Jie Han, Chuan-Gang Zhao, Chengjian Zhu, Hairen Tan, Jin Xie
Summary: This article reports on an iron-catalyzed reaction for efficient construction of aromatic tertiary amines, which is important in drug discovery and organic chemistry. The reaction employs a radical tandem C-N coupling strategy and can synthesize nonsymmetric aromatic tertiary amines under mild conditions.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Gang Li, Liu Yang, Jian-Jun Liu, Wei Zhang, Rui Cao, Chao Wang, Zunting Zhang, Jianliang Xiao, Dong Xue
Summary: This study demonstrates a photochemical C-N coupling of aryl halides with nitroarenes for the first time, catalyzed by a Ni-II complex in the absence of any external photosensitizer. The method provides a step-economic extension to the widely used Buchwald-Hartwig C-N coupling reaction and tolerates coupling partners with steric-congestion and functional groups sensitive to bases and nucleophiles. Mechanistic studies suggest the reaction proceeds via the addition of an aryl radical, generated from a Ni-I/Ni-III cycle, to a nitrosoarene intermediate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Siyuan Wang, Qilin Xue, Zhipeng Guan, Yayu Ye, Aiwen Lei
Summary: A manganese-catalyzed electrochemical intermolecular dehydrogenative cross-coupling reaction between aryl C-H and diphenyl phosphine oxides was reported in this study. By adjusting the proportion of substrates, a series of phosphorylation or diphosphorylation products could be obtained separately, without the need for external chemical oxidants. The research also indicated that C-H activation was not the rate-determining step.
Review
Chemistry, Multidisciplinary
Vignesh Palani, Melecio A. Perea, Richmond Sarpong
Summary: This review discusses strategies for site-selective functionalization of polyhalogenated arenes and heteroarenes, including traditional reaction types and emerging strategies.
Article
Chemistry, Physical
Xin Guo, Hao Ge, Zhijia Sun, Qin Zhao, Yang Tian, Daliang Liu, Qiong Wu, Xi-Ming Song
Summary: In this study, an advanced nanocomposite with abundant metal-oxygen-carbon bonds was fabricated for the first time, which can enhance the intrinsic kinetics and structural stability, and promote the electrode activity. Electrochemical tests showed that the newly prepared electrode exhibited superior long-term durability and ultrafast charging/discharging capability. This work provides a scalable approach for constructing high-performance electrode materials through interfacial regulation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Chemistry, Physical
Shasha Geng, Chaoqun Shi, Bohao Guo, Haoran Hou, Zhengli Liu, Zhang Feng
Summary: Transition-metal-catalyzed reductive cross-coupling reactions using diboron reagents as reductants have gained prominence due to their simplicity and good compatibility, offering advantages over conventional cross-coupling reactions.
Article
Chemistry, Multidisciplinary
Dan Wang, Zhaohua Wan, Heng Zhang, Hesham Alhumade, Hong Yi, Aiwen Lei
Summary: A novel electrochemical reductive arylation method was developed for the efficient synthesis of various diarylamines without the need for transition-metal catalysts. The reaction could be scaled up efficiently in a flow cell, and several derivatization reactions were successfully carried out. Cyclic voltammetry experiments and mechanism studies revealed the roles of acetonitrile, formic acid, and triethyl phosphite in promoting this reductive arylation transformation.
Article
Chemistry, Physical
Roman G. Belli, Victoria C. Tafuri, Matthew Joannou, Courtney C. Roberts
Summary: This study describes a redox-active ligand-enabled alkyl-alkyl cross-coupling method using a d(0) metal, which allows for controlled oxidative addition, prevents beta-hydride elimination, and tolerates hindered electrophiles.
Article
Chemistry, Organic
Yang Cao, Yang Huang, Paul R. Blakemore
Summary: In this study, a desilylative Sonogashira process was employed to prepare 1-methylthio-2-arylethynes and 1-methylthio-2-heteroarylethynes from aryl iodides and 1-methylthio-2-(trimethylsilyl)ethyne. The reaction conditions were optimized to achieve high yields, and the method was also applicable for thioalkynes substituted on sulfur.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Xiao Hai, Yang Zheng, Qi Yu, Na Guo, Shibo Xi, Xiaoxu Zhao, Sharon Mitchell, Xiaohua Luo, Victor Tulus, Mu Wang, Xiaoyu Sheng, Longbin Ren, Xiangdong Long, Jing Li, Peng He, Huihui Lin, Yige Cui, Xinnan Peng, Jiwei Shi, Jie Wu, Chun Zhang, Ruqiang Zou, Gonzalo Guillen-Gosalbez, Javier Perez-Ramirez, Ming Joo Koh, Ye Zhu, Jun Li, Jiong Lu
Summary: Heterogeneous geminal-atom catalysts (GACs) offer a new avenue for the sustainable manufacture of fine chemicals by pairing single-atom sites in specific coordination and spatial proximity.
Review
Chemistry, Multidisciplinary
Dung L. Golden, Sung-Eun Suh, Shannon S. Stahl
Summary: C-H functionalization reactions are important in the preparation and modification of complex organic molecules. There are two main methods: radical-chain and radical-rebound. Recently, it has been found that radical-relay methods can greatly expand the scope and utility of C-H functionalization and cross coupling.
NATURE REVIEWS CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Stavros K. Kariofillis, Abigail G. Doyle
Summary: In recent years, the development of light-driven reactions has made significant advancements in synthetic organic chemistry, particularly in combining photoredox and nickel catalysis for challenging cross-coupling reactions. The question of whether photo-induced activation of the nickel catalyst itself could lead to new approaches to cross-coupling has been explored. By utilizing a visible-light-driven mechanism for chlorine radical formation and conducting mechanistic investigations on organometallic Ni complexes relevant to cross-coupling, the study aims to facilitate new catalyst design and develop novel synthetic methods.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)