Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety

The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics

(2018) Michelle F. Richter et al.   Annals of the New York Academy of Sciences

Antibacterial Drug Discovery: Some Assembly Required

(2018) Rubén Tommasi et al.   ACS Infectious Diseases

Re-estimating annual deaths due to multidrug-resistant organism infections

(2018) Jason P. Burnham et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Notes from the Field: Pan-Resistant New Delhi Metallo-Beta-Lactamase-Producing Klebsiella pneumoniae — Washoe County, Nevada, 2016

(2017) Lei Chen et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Antibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC

(2016) Alice L. Erwin   Cold Spring Harbor Perspectives in Medicine

Rational Use of Plasma Protein and Tissue Binding Data in Drug Design

(2014) Xingrong Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploring the UDP pocket of LpxC through amino acid analogs

(2013) Michael R. Hale et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS