期刊
CEREBRAL CORTEX
卷 30, 期 3, 页码 989-1000出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhz142
关键词
[C-11] raclopride; catechol-O-methyltransferase; dopamine D2 receptors; episodic memory; working memory
资金
- Swedish Research Council, Umea University
- Knut and Alice Wallenberg Foundation
- Torsten and Ragnar Soderberg Foundation
- Jochnick Foundation
- Swedish Brain Power
- Swedish Brain Foundation
- Vasterbotten County Council
- Innovation Fund of the Max Planck Society
- German Research Foundation (DFG)
- Umea University-Karolinska Institute Strategic Neuroscience Program
Insufficient or excessive dopaminergic tone impairs cognitive performance. We examine whether the balance between transmitter availability and dopamine (DA) D2 receptors (D2DRs) is important for successful memory performance in a large sample of adults (n= 175, 64-68 years). The Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal DA availability, and D2DRs in dorsolateral prefrontal cortex (dlPFC) were measured with [C-11]raclopride-PET. Individuals for whom D2DR status matched DA availability showed higher levels of episodic and working-memory performance than individuals with insufficient or excessive DA availability relative to the number of receptors. A similar pattern restricted to episodic memory was observed for D2DRs in caudate. Functional magnetic resonance imaging data acquired during working-memory performance confirmed the importance of a balanced DA system for load-dependent brain activity in dlPFC. Our data suggest that the inverted-U-shaped function relating DA signaling to cognition is modulated by a dynamic association between DA availability and receptor status.
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