期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 22, 页码 4407-4412出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-019-03273-4
关键词
Moonlighting proteins; Multifunctional proteins; Cell signalling regulation; Short linear motifs; Molecular switch; Protein interaction networks; Bioinformatics
资金
- Excellence Initiative of Aix-Marseille University - A*MIDEX, a French Investissements d'Avenir programme
Moonlighting proteins perform multiple unrelated functions without any change in polypeptide sequence. They can coordinate cellular activities, serving as switches between pathways and helping to respond to changes in the cellular environment. Therefore, regulation of the multiple protein activities, in space and time, is likely to be important for the homeostasis of biological systems. Some moonlighting proteins may perform their multiple functions simultaneously while others alternate between functions due to certain triggers. The switch of the moonlighting protein's functions can be regulated by several distinct factors, including the binding of other molecules such as proteins. We here review the approaches used to identify moonlighting proteins and existing repositories. We particularly emphasise the role played by short linear motifs and PTMs as regulatory switches of moonlighting functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据