Review
Medicine, Research & Experimental
Yihui Yang, Liwen Ren, Wan Li, Yizhi Zhang, Sen Zhang, Binbin Ge, Hong Yang, Guanhua Du, Bo Tang, Hongquan Wang, Jinhua Wang
Summary: GABA is a common inhibitory neurotransmitter in the central nervous system of vertebrates, and recent studies have shown its involvement in tumor development and immune regulation. This review summarizes the role of GABAergic signaling in tumor proliferation, metastasis, progression, stemness, and the tumor microenvironment, as well as the underlying molecular mechanisms. The therapeutic advances in targeting GABA receptors for cancer treatment, particularly immunotherapy, are also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Xiyin Li, Lina Zhao, Ceshi Chen, Jianyun Nie, Baowei Jiao
Summary: This review summarizes the regulatory mechanisms of EGFR protein expression in breast cancer cells, including mutations, amplification, endocytic dysfunction, recycling acceleration, and degradation disorders. Potential therapeutic strategies targeting EGFR, such as reducing protein expression, precise clearance of target proteins, and inhibiting non-EGFR signaling pathways, are also discussed.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Oncology
Maria Paz Saldias, Diego Maureira, Octavio Orellana-Serradell, Ian Silva, Boris Lavanderos, Pablo Cruz, Camila Torres, Monica Caceres, Oscar Cerda
Summary: Breast cancer is a leading cause of cancer-related deaths in women globally, and developing new molecular therapies to target the disease is crucial. Ion channels play a significant role in cancer progression, making them potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hussein Al-Akhrass, Mika Pietila, Johanna Lilja, Ella-Maria Vesilahti, Johanna M. Anttila, Heidi M. Haikala, Pauliina M. Munne, Juha Klefstrom, Emilia Peuhu, Johanna Ivaska
Summary: SorLA is a druggable target in breast cancer, as demonstrated by the ability of anti-SorLA antibody to alter breast cancer cells' resistance to HER2 monoclonal antibodies and inhibit tumor cell proliferation and density.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fabienne Bejjani, Claire Tolza, Mathias Boulanger, Damien Downes, Raphael Romero, Muhammad Ahmad Maqbool, Amal Zine El Aabidine, Jean-Christophe Andrau, Sophie Lebre, Laurent Brehelin, Hughes Parrinello, Marine Rohmer, Tony Kaoma, Laurent Vallar, Jim R. Hughes, Kazem Zibara, Charles-Henri Lecellier, Marc Piechaczyk, Isabelle Jariel-Encontre
Summary: The dimeric transcription factors AP-1, composed of Fos and Jun family proteins, play a key role in gene regulation. The overexpression of the Fos family protein Fra-1 in triple negative breast cancers contributes to tumor aggressiveness, while its actions in controlling transcription remain complex and involve a wide range of biological processes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Immunology
Jing-Yan Cheng, Jung-Tung Hung, Juway Lin, Fei-Yun Lo, Jing-Rong Huang, Shih-Pin Chiou, Ya-Hui Wang, Ruey-Jen Lin, Jen-Chine Wu, John Yu, Alice L. Yu
Summary: OAcGD2 is a novel marker for breast cancer stem cells, and treatment with anti-OAcGD2 mAb8B6 can suppress tumor growth and reduce cancer metastasis and recurrence.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Atsushi Takatori, Md Shamim Hossain, Atsushi Ogura, Jesmin Akter, Yohko Nakamura, Akira Nakagawara
Summary: NLRR1 acts as a key regulator of tumor cell proliferation by promoting cell proliferation through its FNIII domain. Monoclonal antibody N1mAb reduces tumor cell proliferation and sensitizes cells to EGFR inhibitor, indicating NLRR1 as a novel regulatory molecule of RTK function.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yifei Wang, Man Tong
Summary: The posttranslational modifications (PTMs) of proteins play a critical role in protein regulation, enhancing proteome functional diversity and participating in complicated biological processes. In cancer biology, PTMs have been shown to interact with pro-tumorigenic signaling pathways, contributing to neoplastic transformation, tumor recurrence, and resistance to therapy. Cancer stemness, which maintains tumor cell self-renewal and differentiation, is essential in cancer development and therapy resistance. Understanding the PTM profile for modulating cancer stemness has shed light on the underlying mechanisms and potential therapeutic targets for gastrointestinal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Fei-Fei Yang, Xue-Li Xu, Ting Hu, Jian-Quan Liu, Jin-Zhu Zhou, Li-Ying Ma, Hong-Min Liu
Summary: Chemotherapy, targeted therapy, and immunotherapy can effectively treat most tumors, but drug resistance limits their success. Lysine-specific demethylase 1 (LSD1) plays a role in regulating tumor cell invasion, metastasis, apoptosis, and immune evasion, which are associated with tumor development and progression. Recent studies have found that LSD1 inhibition can restore sensitivity of tumor cells to anticancer drugs containing immune checkpoint inhibitors (ICIs) through various pathways. This review discusses the role of LSD1 in cancer drug resistance and explores the potential of using LSD1 inhibitors in combination with other agents to overcome resistance.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Multidisciplinary Sciences
Claire Shao, Vivek Anand, Michael Andreeff, Venkata Lokesh Battula
Summary: TNBC is a heterogeneous disease characterized by lack of hormone receptor expression, with high recurrence and distant metastasis rates. Targeting breast cancer stem-like cells is an effective strategy for preventing metastatic spread and enhancing sensitivity to chemotherapy.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Oncology
Vladimir Bezrookove, Imran A. Khan, Mehdi Nosrati, James R. Miller, Sean McAllister, Altaf A. Dar, Mohammed Kashani-Sabet
Summary: This study investigates the biomarker and functional role of the chromatin remodeling factor BPTF in breast cancer progression. The results demonstrate that BPTF activation is present in distinct breast cancer subtypes and plays a crucial role in promoting breast cancer progression through various signaling pathways. Furthermore, pharmacological inhibition of BPTF using a bromodomain inhibitor shows significant anti-tumor effects both in vitro and in vivo, suggesting BPTF as a potential target for breast cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
K. Weiner-Gorzel, M. Murphy
Summary: Triple Negative Breast Cancer (TNBC) is an aggressive tumor with poor prognosis, and mitochondrial dynamics play a critical role in TNBC, understanding and exploring this mechanism may help improve patient outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Xingzhao Luan, Jian Feng, Li Deng, Yumei Zuo, Jiafu Li
Summary: This review summarizes the role of pyroptosis and the inflammasome in the development of diabetic cardiomyopathy (DCM) and discusses potential anti-DCM strategies targeting this pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yomna S. Abd El-Aziz, Josef Gillson, Patric J. Jansson, Sumit Sahni
Summary: This review discusses the critical role of autophagy in the progression of triple negative breast cancer (TNBC) and introduces recent therapeutic approaches that target autophagy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Oncology
Elena Levantini, Giorgia Maroni, Marzia Del Re, Daniel G. Tenen
Summary: EGFR plays an important role in maintaining epithelial tissues, but when its signaling is altered, it becomes a major regulator of epithelial transformation and is one of the most studied tyrosine kinase receptors involved in neoplasia worldwide. EGFR-targeted therapies have revolutionized cancer treatment, but the dream of turning solid tumors into chronic diseases remains unfulfilled.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Geosciences, Multidisciplinary
Lin Li, Yani Najman, Guillaume Dupont-Nivet, Mauricio Parra, Pierrick Roperch, Mustafa Kaya, Niels Meijer, Paul O'Sullivan, Gilby Jepson, Jovid Aminov
Summary: This study uses detrital apatite and zircon fission-track ages to analyze the tectonic history of the Pamir region. The results indicate two significant Mesozoic exhumation events associated with the Late Triassic-Early Jurassic Cimmerian orogeny and the Early-early Late Cretaceous northward subduction of the Neo-Tethys Ocean. The study also reveals Late Eocene-Neogene exhumation related to the ongoing formation of the Pamir.
Article
Chemistry, Analytical
Pan Fu, Hao Chen, Lilin Ouyang, Lin Li, Yuhui Wang, Sihua Qian, Zhanglei Cao, Kerong Wu, Jie Chao, Jianping Zheng
Summary: In this study, a simple and efficient DNA nanoribbon (DNR)-based drug delivery process was designed to release asPNA and inhibit oncogenic miRNAs. The AS1411 aptamer was used as a control mechanism to identify target cancer cells and enhance the enrichment capacity of DNR. With the biodegradability of DNR, asPNA could be efficiently released into the cytoplasm, specifically targeting miR-21 and increasing PDCD4 expression to enhance cell apoptosis. This well-defined delivery mechanism may aid in designing site-specific antisense treatments for various diseases, including cancer.
ANALYTICAL CHEMISTRY
(2023)
Letter
Virology
Xun Wang, Xing He, Shujun Jiang, Zhangfan Fu, Shuai Jiang, Xiaoyu Zhao, Chaoyue Zhao, Yaning Li, Dianfan Li, Wenhong Zhang, Jingwen Ai, Yanliang Zhang, Chenqi Xu, Pengfei Wang
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Geosciences, Multidisciplinary
Nandini Kar, Lin Li, Victor Carlotto, Carmala N. Garzione, Federico Moreno, Sarah Smith
Summary: The Paleocene-Miocene sedimentary successions in southern Peru reveal the growth history of the northern Altiplano Plateau and foreland basin system. Through analyzing paleoelevation history, the study determines significant surface uplift during primary upper crustal shortening. New age models and calculations based on isotopic values suggest rapid surface uplift during late Miocene, potentially due to lower crustal flow and removal of lithosphere materials.
JOURNAL OF SOUTH AMERICAN EARTH SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lin Li, Hu Luo, Zilong Shao, Haozhi Zhou, Junwen Lu, Junjun Chen, Chaojie Huang, Shunan Zhang, Xiaofang Liu, Lin Xia, Jiong Li, Hui Wang, Yuhan Sun
Summary: We present a tandem catalytic conversion of LDPE into naphtha, the key feedstock for renewable plastic production, to address the serious environmental problem and resource waste of plastic pollution. The use of beta zeolite and silicalite-1-encapsulated Pt nanoparticles (Pt@S-1) enables a high naphtha yield of 89.5% and selectivity of 96.8% for C5-C9 hydrocarbons at 250 degrees C. This method utilizes acid sites to crack LDPE into olefin intermediates, which then encounter Pt nanoparticles within the channels of Pt@S-1 for hydrogenation and selective shipping of the resulting olefins, leading to the formation of narrow-distributed alkanes. Conceptually, this approach is suitable for closing the plastic loop, offering significant energy savings of 15% and a 30% reduction in greenhouse gas emissions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Microbiology
Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao, Congli Jiang, Yuanfei Zhu, Teng Li, Lu Lu, Junqi Zhang, Heng Yang, Jian Feng, Zhifeng Gu, Hong Tang, Lubin Jiang, Dianfan Li, Dimitri Lavillette, Xiaoming Zhang
Summary: A monoclonal antibody (Ab08) isolated from a convalescent patient effectively neutralizes SARS-CoV-2 and its variants, and shows therapeutic potential in infected mice.
Article
Multidisciplinary Sciences
Hong-Hong Wei, Guo-Li Wu, Lin Ding, Long-Gang Fan, Lin Li, Qing-Ren Meng
Summary: The mid-Tertiary uplift of the NE Tibetan plateau is likely driven by edge convection, which explains various geological phenomena. There are contrasting views on the timing and mechanisms of the uplift, with many attributing it to crustal shortening. However, a comprehensive investigation challenges these previous views and suggests a different mechanism involving vertical crustal uplifting and supracrustal stretching.
NATIONAL SCIENCE REVIEW
(2023)
Letter
Oncology
Cuidan Li, Liya Yue, Yingjiao Ju, Jie Wang, Hao Lu, Lin Li, Mengfan Chen, Chenyang Wang, Shuangshuang Li, Tao Liu, Sitong Liu, Tianyi Lu, Jing Wang, Xin Hu, Chunlai Jiang, Dongsheng Zhou, Fei Chen
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Mechanical
Chi Xu, Xinyi Du, Xinchun Li, Yachun Tu, Lin Li, Xi Jin, Changqing Xia
Summary: This paper investigates the protocol adaptation and experimental evaluations for the development of a 5G-based industrial wireless controller prototype. The characteristics of data packet format and communication time sequence of Modbus RTU, Modbus TCP, and 5G protocols are deeply analyzed. A protocol resolution and conversion scheme for the protocol adaptation between Modbus RTU/Modbus TCP and 5G is proposed. Extensive experiments are performed to test the reliability and latency, and the results show that the protocol adaptation scheme has lower latency and acceptable reliability.
Article
Geography, Physical
Florian Schwarz, Ulrich Salzmann, Feng Cheng, Jian Ni, Junsheng Nie, Megan R. Patchett, Xiangzhong Li, Lin Li, John Woodward, Carmala Garzione
Summary: This study presents a 3.5-million-year-long record of vegetation and climate from the Kunlun Pass Basin on the Tibetan Plateau. The results show the transition from a warm, high carbon dioxide environment in the Early Pliocene to the cool glacial and interglacial periods of the Pleistocene, indicating amplified warming and permafrost conditions after 2.7 Ma.
GLOBAL AND PLANETARY CHANGE
(2023)
Article
Chemistry, Physical
Shunan Zhang, Chaojie Huang, Zilong Shao, Haozhi Zhou, Junjun Chen, Lin Li, Junwen Lu, Xiaofang Liu, Hu Luo, Lin Xia, Hui Wang, Yuhan Sun
Summary: This study reveals the reaction network of direct CO2 hydrogenation to higher alcohols on Co2C and CuZnAl multifunctional tandem catalysts. The key step for C-C coupling to form C2+OH was the insertion of CO into R-CHx on the Co2C catalyst, while on the tandem catalyst (Co2C||CuZnAl), the reaction can be modulated to the coupling of R-CH2 and CHO with a lower energy barrier. These multifunctional tandem catalysts showed a high space-time yield of C2+OH of 2.2 mmol g-1 h-1. This work provides an effective strategy for studying complex reaction mechanisms and optimizing reaction pathways.
Review
Medicine, General & Internal
Yirong Liu, Brian Chou, Amulya Yalamanchili, Sara N. Lim, Laura A. Dawson, Tarita O. Thomas
Summary: Hepatocellular carcinoma (HCC) is a common liver tumor, and its incidence is increasing. Surgical resection or liver transplantation is the curative treatment, but only a small portion of patients are eligible. Most HCC patients receive nonsurgical liver-directed therapies (LDTs), including thermal ablation, TACE, TARE, and EBRT. SABR, a specific type of EBRT, can deliver a high dose of radiation using a small number of treatments. MRI-guided SABR improves therapeutic dose and reduces normal tissue exposure. This review discusses different LDTs and compares them with EBRT, focusing on SABR. The potential role of MRI-guided adaptive radiation therapy in HCC management is also highlighted.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yidan Xu, Tingting Li, Zixuan Zhou, Jingjing Hong, Yulin Chao, Zhini Zhu, Ying Zhang, Qianhui Qu, Dianfan Li
Summary: This study reveals the structural features underlying the broad specificity of GPI-T and a fidelity mechanism that involves the synergistic binding of substrate regions with individually weak specificity.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Shunan Zhang, Chaojie Huang, Zilong Shao, Haozhi Zhou, Junjun Chen, Lin Li, Junwen Lu, Xiaofang Liu, Hu Luo, Lin Xia, Hui Wang, Yuhan Sun
Summary: Revealing the complex reaction mechanism of CO2 hydrogenation to higher alcohols on Co2C and CuZnAl multifunctional tandem catalysts, this work provides an effective strategy for the design of highly efficient catalysts and optimization of reaction pathways. The key C-C coupling step was found to be the insertion of CO into R-CHx on the Co2C catalyst, while on the tandem catalyst (Co2C||CuZnAl), the coupling of R-CH2 and CHO with a lower energy barrier was observed. The multifunctional tandem catalysts exhibited a high space-time yield of C2+OH of 2.2 mmol g-1 h-1.
Proceedings Paper
Computer Science, Hardware & Architecture
Lingang Li, Zhijun Li, Yongrui Chen, Jiajun Zhang, Lin Li
Summary: Congestion control is a significant issue in wireless networks. This study proposes a congestion control algorithm called QCC, which adjusts the congestion window based on the relationship between the real-time length of the NIC driver queue and transmission performances. By tracking the queue length and dynamically adjusting the congestion window, QCC achieves high throughput and low latency.
2022 IEEE 30TH INTERNATIONAL CONFERENCE ON NETWORK PROTOCOLS (ICNP 2022)
(2022)
