Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

(2019) Zhaohui Gu et al.   NATURE GENETICS

ETV6/RUNX1 -like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype

(2017) Marketa Zaliova et al.   GENES CHROMOSOMES & CANCER

ZNF384 -related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype

(2016) Shinsuke Hirabayashi et al.   HAEMATOLOGICA

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia

(2016) Henrik Lilljebjörn et al.   Nature Communications

ZNF384 -related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype

(2016) Shinsuke Hirabayashi et al.   HAEMATOLOGICA

Identification of a DNA methylation signature in blood cells from persons with Down Syndrome

(2016) Maria Giulia Bacalini et al.   Aging-US

Transcriptional Auto-Regulation of RUNX1 P1 Promoter

(2016) Milka Martinez et al.   PLoS One

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

(2015) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

(2015) Kathryn G. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

(2014) Andrew A Lane et al.   NATURE GENETICS

Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

(2014) Sergey I. Nikolaev et al.   Nature Communications

DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo

(2013) B. R. Webber et al.   BLOOD

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

(2013) T. D. Buitenkamp et al.   BLOOD

Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes

(2013) S. Malinge et al.   BLOOD

Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols

(2013) I Öfverholm et al.   LEUKEMIA

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

(2013) Jessica Nordlund et al.   GENOME BIOLOGY

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

(2012) Andrew E. Teschendorff et al.   BIOINFORMATICS

A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network

(2012) Seung-Tae Lee et al.   NUCLEIC ACIDS RESEARCH

Pediatric acute lymphoblastic leukemia with a t(8;14)(q11.2;q32): B-cell disease with a high proportion of Down syndrome: a Children's Oncology Group study

(2012) Yoav H. Messinger et al.   Cancer Genetics

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

(2010) R. C. Harvey et al.   BLOOD

Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

(2010) Pan Du et al.   BMC BIOINFORMATICS

Telomere aggregates in trisomy 21 amniocytes

(2009) Efrat Hadi et al.   CANCER GENETICS AND CYTOGENETICS

Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia

(2008) M. Case et al.   CANCER RESEARCH