Article
Biochemistry & Molecular Biology
Casey J. Keuthan, Julie A. Schaub, Meihan Wei, Weixiang Fang, Sarah Quillen, Elizabeth Kimball, Thomas V. Johnson, Hongkai Ji, Donald J. Zack, Harry A. Quigley
Summary: The level of intraocular pressure (IOP) is a major risk factor for glaucomatous optic neuropathy. This study found that the unmyelinated optic nerve region is differentially susceptible to IOP-induced damage compared to the myelinated region. Gene expression patterns in the unmyelinated optic nerve showed significant differences compared to the myelinated optic nerve and retina. Changes in gene expression induced by optic nerve injury were more extensive in the myelinated region than the unmyelinated region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Mona Safizadeh, Amirreza Shaabani, Alireza Kamalipour, Masoud Aghsaei Fard, Kaileen Yeh, Mehdi Yaseri, Nikoo Hamzeh, Nassim Khatibi, Harsha Laxmana Rao, Robert Weinreb, Sasan Moghimi
Summary: OCTA can be used to detect reduced capillary density in fellow eyes of PXG patients, enabling earlier detection of glaucomatous loss in pseudoexfoliation disease and enhancing disease management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Thanadet Chuangsuwanich, Tin A. Tun, Fabian A. Braeu, Xiaofei Wang, Zhi Yun Chin, Satish K. Panda, Martin Buist, Dan Milea, Nicholas Strouthidis, Shamira Perera, Monisha Esther Nongpiur, Tin Aung, Michael J. A. Girard
Summary: This study aimed to assess the strains in optic nerve head (ONH) induced by intraocular pressure (IOP) and gaze in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). The results showed that NTG subjects experienced higher strains due to gaze, while HTG subjects experienced higher strain due to IOP elevation, and these differences were most pronounced in the lamina cribrosa (LC) tissue.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yue Zhang, Kai Cao, Ruiqi Pang, Ning Wang, Xin Qu, Jun Kang, Ningli Wang, Hanruo Liu
Summary: The area of the ONSAS obtained by transorbital ultrasonography can accurately evaluate the intracranial pressure (ICP), and a mathematical formula considering BMI and MABP as contributing parameters is the best predictive model.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim, Hee Kyung Yang, Jeong-Min Hwang
Summary: The microvasculature of the optic nerve head and peripapillary tissues in eyes with normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) was compared using optical coherence tomography angiography (OCTA). Despite similar levels of retinal nerve fiber layer loss and vessel density decreases in the peripapillary retina, there were differences in vessel densities in the optic nerve head between NTG and NAION eyes, suggesting distinct mechanisms of vascular impairment and optic nerve head damage in each condition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Rami Darwich, Faisal Jarrar, Mustafa Syed, Glen P. Sharpe, Balwantray C. Chauhan
Summary: Both spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) showed similar visualization of optic nerve head (ONH) structures, with a tendency for higher visualization rates with SS-OCT.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Cell Biology
Anisha Kasi, Crystal Liu, Muneeb A. Faiq, Kevin C. Chan
Summary: Optic nerve health is crucial for normal visual system function. There is growing evidence suggesting that the inability to clear neurotoxins may contribute to neurodegenerative diseases affecting the optic nerve. While the brain lacks traditional lymphatic drainage, there may be a glymphatic system in the central nervous system, including the optic nerve, which plays a vital role in removing toxic waste.
NEURAL REGENERATION RESEARCH
(2022)
Article
Ophthalmology
Eugene A. Lowry, Steven L. Mansberger, Stuart K. Gardiner, Hongli Yang, Facundo Sanchez, Juan Reynaud, Shaban Demirel, Claude F. Burgoyne, Brad Fortune
Summary: The frequency and severity of optic nerve head prelaminar schisis were found to be greater in glaucoma and glaucoma suspect eyes compared to healthy control eyes, and were associated with markers of glaucoma severity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Cell Biology
Sijia Huang, Kexin Liu, Ying Su, Feng Wang, Tao Feng
Summary: Ferroptosis, a novel type of programmed cell death, is associated with eye diseases such as glaucoma and optic nerve damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Ophthalmology
Golnoush Mahmoudinezhad, Mark Lin, Alessandro Rabiolo, Esteban Morales, Pradtana Hirunpatravong, Farideh Sharifipour, Joseph Caprioli
Summary: The presence of an acquired pit of the optic nerve in patients with primary open-angle glaucoma is associated with fast rates of visual field decay. Identifying patients with this condition may indicate a need for aggressive treatment to slow down the progression of their glaucoma.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yasushi Kitaoka, Kana Sase
Summary: The optic nerve consists of various components including glia, vessels, and axons. Understanding the molecular mechanisms of optic nerve degeneration can be aided by studying axonal degeneration models. Autophagy plays a crucial role in this process, and its impairment may lead to axonal degeneration. Enhancing autophagy can potentially protect the axons and prevent further cell death.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Ophthalmology
Fabian A. Braeu, Thanadet Chuangsuwanich, Tin A. Tun, Shamira Perera, Rahat Husain, Alexandre H. Thiery, Tin Aung, George Barbastathis, Michael J. A. Girard
Summary: Using artificial intelligence techniques, the study aims to assess the robustness of the optic nerve head (ONH) by analyzing biomechanical knowledge through optical coherence tomography (OCT). Three AI algorithms were compared to predict ONH robustness and the DGCNN algorithm outperformed the others. The study suggests that ONH robustness can be assessed from a single OCT scan, providing potential insights into identifying fast visual field loss progressors.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Carmen Mendez-Hernandez, Surina Wang, Paula Arribas-Pardo, Liseth Salazar-Quinones, Noemi Guemes-Villahoz, Cristina Fernandez-Perez, Julian Garcia-Feijoo
Summary: The study found significant differences in multiple indicators between patients with retinal diseases and normal subjects, with the wcpVD, iVD, wmVD, and ONH Hb showing the most prominent differences.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Neurosciences
Nathaniel Pappenhagen, Eric Yin, Autumn B. Morgan, Charles C. Kiehlbauch, Denise M. Inman
Summary: This study investigated the metabolic changes in optic nerve head astrocytes and found significant differences in glycolytic and respiratory activity between stretched and control cells. Stretched optic nerve head astrocytes showed increased dependency on glutamine, suggesting the need for NAD + replenishment for sustained glycolysis and provision of carbon for TCA cycle intermediates.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Timur A. Mavlyutov, Justin J. Myrah, Anil K. Chauhan, Yang Liu, Colleen M. McDowell
Summary: The study showed that B6.EDA(+/+) mice exhibit increased ECM accumulation in the TM, elevated IOP, enhanced proinflammatory changes in the ONH, loss of RGCs, and ONH damage. These data suggest that B6.EDA(+/+) mice recapitulate many aspects of glaucomatous damage.
CELL AND BIOSCIENCE
(2022)
Article
Ophthalmology
Hyungjun Kim, Hae Min Park, Hyo Chan Jeong, So Yeon Moon, Hyunsoo Cho, Han Woong Lim, Mincheol Seong, Junhong Park, Won June Lee
Summary: This study aimed to establish a wide-field optical coherence tomography (OCT) deviation map for the detection of early glaucoma (EG). The wide-field deviation map showed high diagnostic ability and visualized a wider damaged area, making it useful for EG diagnosis in clinical settings.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ahnul Ha, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: This study aimed to investigate the relationship between optic disc morphological changes during myopia progression and the development of retinal nerve fiber layer defect (RNFLD). The results showed that progressive optic disc tilt during myopia progression was associated with a higher risk of RNFLD development in children with large vertical cup-to-disc ratio (vCDR).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Sooyeon Choe, Ahnul Ha, Seulggie Choi, Sung Uk Baek, Jin-Soo Kim, Jin Wook Jeoung, Ki Ho Park, Young Kook Kim
Summary: The purpose of this study was to determine the incidence of infantile cataract (IC) surgery and the risk of secondary glaucoma in the Korean population. A retrospective cohort study was conducted using the Korean National Health Claims database. The study found that the annual incidence of IC surgery ranged from 5.10 to 9.29 cases per 100,000 individuals, and the incidence rate of post-IC surgery glaucoma was 2.29 per 100 person-years. Factors such as intraocular lens implantation were found to reduce the risk of post-IC surgery glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ahnul Ha, Su Hwan Kim, Sung Uk Baek, Jin-Soo Kim, Hyung-Jin Yoon, Young Kook Kim
Summary: This nationwide retrospective cohort study aimed to determine the incidence of Sturge-Weber syndrome (SWS) and the risk of secondary glaucoma. The study utilized the Korean National Health Insurance claims database and the rare disease registry to identify confirmed SWS patients. The results showed that the mean birth-cohort SWS incidence was 3.08 per 100,000 people per year, and 8.3% of SWS patients developed SWS-associated glaucoma.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Sooyeon Choe, Young Kook Kim, Woosuk Chung, Donghyun Ko, Marvin Lee, Sung Ryul Shim, Ahnul Ha
Summary: This study found that placebo is effective in lowering intraocular pressure and is superior to the effect observed in untreated control participants. However, caution is required in interpreting the results due to the limited number of trials with untreated control groups and the lack of direct comparison between placebo and untreated arms.
Review
Multidisciplinary Sciences
Chung Young Kim, Ahnul Ha, Sung Ryul Shim, In Boem Chang, Young Kook Kim
Summary: This study aims to systematically review and meta-analyze the association between visual impairment (VI) and risk of suicide. The findings of this study will contribute to our current knowledge of the impact of VI as a risk factor of suicide. Additionally, meta-regression and subgroup analyses will provide further insights to factors affecting the association between VI and suicide risk.
Article
Ophthalmology
Sooyeon Choe, Young Kook Kim, Ki Ho Park, Hyuk Jin Choi, Jin Wook Jeoung
Summary: This study investigated the natural history of optic disc with physiologic large cup (PLC), as well as the risk factors for glaucoma conversion. The study identified higher VCDR, violation of the inferior superior nasal temporal neuroretinal rim thickness rule, presence of retinal arterial sclerosis, and lower total bilirubin level as factors associated with glaucoma development.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ahnul Ha, Sukkyu Sun, Young Kook Kim, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park
Summary: This study assessed the performance of deep-learning models in predicting conversion to normal-tension glaucoma, and found that the models showed good predictive ability.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Sung Uk Baek, Jin-Soo Kim, Dai Woo Kim, Ahnul Ha, Young Kook Kim
Summary: This study aims to investigate the impact of psychological states such as anxiety, depression, and stress on medication adherence and disease progression in glaucoma patients. By using validated questionnaires and glaucomatous assessments, the researchers hope to identify the correlation between psychological status and glaucoma management, as well as the effects of psychological state changes on disease progression.
Article
Medicine, General & Internal
Yoon Jeong, Su Hwan Kim, Goneui Kang, Hyung-Jin Yoon, Young Kook Kim, Ahnul Ha
Summary: This study found that abstaining from alcohol after being diagnosed with open-angle glaucoma (OAG) was associated with a lower risk of severe visual impairment or blindness. These findings suggest that lifestyle interventions, such as alcohol abstinence, could be essential for newly diagnosed OAG patients.
Article
Medicine, General & Internal
Kyeong Ik Na, Won June Lee, Young Kook Kim
Summary: In this study, the prevalence of blindness in Korean adults was analyzed based on a sample of 10 million participants. The findings suggest a gradual decrease in the prevalence of blindness over a ten-year period, and identified specific systemic health conditions that are associated with blindness. These results provide valuable insights for public health policies and prevention/rehabilitation efforts for blindness.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
