Article
Oncology
Angelina Regua, Csaba Papp, Andre Grageda, Baylee A. Porter, Tiffany Caza, Isabelle Bichindaritz, Mira Krendel, Abirami Sivapiragasam, Gennady Bratslavsky, Vladimir A. Kuznetsov, Leszek Kotula
Summary: Breast cancer remains one of the leading causes of mortality in women worldwide, and there is a need for better predictive and therapeutic targets. This study identifies ABI1 as a prognostic biomarker for breast cancer metastasis and demonstrates that genetic disruption of the ABI1 gene reduces lung metastases in mice. The study also shows that aberrations in ABI1 gene expression are associated with lung metastasis in primary breast cancer tumors. Targeting ABI1 may provide a therapeutic advantage for breast cancer patients.
MOLECULAR ONCOLOGY
(2022)
Review
Oncology
Baohong Song, Wei Wang, Xuemei Tang, Robby Miguel Wen-Jing Goh, Win Lwin Thuya, Paul Chi Lui Ho, Lu Chen, Lingzhi Wang
Summary: Cancer metastasis is a major challenge in cancer treatment, and resveratrol has shown potential as an anticancer agent to suppress metastasis. However, progress in clinical trials has been limited. Understanding its cellular processes and signaling pathways in tumor metastasis is crucial to develop resveratrol as an effective anticancer agent. This review evaluates the current state and future development strategies of resveratrol against cancer metastasis and discusses novel techniques to accelerate its translation from bench to bedside.
Review
Oncology
Shuangshuang Mei, Xing Chen, Kai Wang, Yuxin Chen
Summary: Ovarian cancer is a common gynecological malignancy with high morbidity and mortality. Peritoneal metastasis is common in ovarian cancer, involving large amounts of ascites. The mechanism behind this is still unclear.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Lucas W. Thornblade, Ernest Han, Yuman Fong
Summary: Patients with colorectal cancer ovarian metastasis have favorable long-term survival. Survival rates are higher if the tumor is isolated to the ovary or if metachronous to the primary cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Reproductive Biology
Shree Bose, Haipei Yao, Qiang Huang, Regina Whitaker, Christopher D. Kontos, Rebecca A. Previs, Xiling Shen
Summary: This study demonstrates the potential of genetically encoded fluorescent biosensors in studying ovarian cancer (OC) and its metabolic changes. Using 3D organoid models and intravital imaging, the researchers were able to better understand the dynamic metabolic adaptations in OC. These findings contribute to our understanding of OC metastasis and its treatment.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Cell Biology
Jing Cai, Lanqing Gong, Guodong Li, Jing Guo, Xiaoqing Yi, Zehua Wang
Summary: Poor prognosis of ovarian cancer is mainly due to metastasis, with ascites-derived exosomes playing a role in promoting metastasis through epithelial-mesenchymal transition. The key microRNA miR-6780b-5p in ADEs facilitates cancer metastasis by promoting EMT in ovarian cancer cells, indicating a potential mechanism for ovarian cancer progression.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Ana Duarte Mendes, Ana Rita Freitas, Rodrigo Vicente, Marina Vitorino, Marta Vaz Batista, Michelle Silva, Sofia Braga
Summary: Ovarian cancer has a complex relationship with the adipose tissue microenvironment. Peritoneal metastasis is one of the main factors contributing to poor prognosis. Adipose tissue may play a role in promoting cancer development, but its specific functions in ovarian cancer are not fully understood. Obesity can lead to metabolic and inflammatory changes in the adipose tissue microenvironment, potentially increasing the risk of tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Xiameng Shen, Conghui Wang, Huihui Zhu, Yaping Wang, Xinyu Wang, Xiaodong Cheng, Wanzhong Ge, Weiguo Lu
Summary: Tumor-derived exosomes play important roles in promoting migration and invasion of ovarian cancer cells. CD44, transferred through exosomes, influences the metastatic phenotype of cancer cells and may be a potential therapeutic target for ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Kosuke Yoshida, Nobuhisa Yoshikawa, Kazuhisa Kitami, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi, Hiroaki Kajiyama
Summary: The study investigated metabolomic differences in epithelial ovarian cancers, finding significant variations in metabolite profiles between metastatic and primary cancers. Urea concentration was notably decreased in omental metastatic cancers, and the pentose phosphate pathway was more dominant in these cancers. Additionally, amino acid levels, particularly the percentage of glutamine, were significantly enriched in serous carcinomas compared to nonserous carcinomas.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Shanta Bhattarai, Yuri Mackeyev, Bhanu P. Venkatesulu, Sunil Krishnan, Pankaj K. Singh
Summary: CXCR4-targeted gold nanoparticles show enhanced radiosensitization of breast cancer cells with CXCR4 overexpression, leading to increased cellular internalization, unrepaired DNA double strand breaks, and production of oxygen free radicals. In a murine TNBC xenograft model, CXCR4 targeting significantly increases tumor regrowth delay following radiation compared to radiation with non-targeted GNPs or vehicle alone, suggesting that CXCR4-targeted GNPs can enhance the efficacy of TNBC radiotherapy through increasing oxidative stress and DNA damage.
Review
Cell Biology
Jacob P. Veenstra, Lucas Felipe Fernandes Bittencourt, Katherine M. Aird
Summary: Ovarian cancer is a highly aggressive disease, often diagnosed late after it has spread. Inflammatory signals and cellular senescence play important roles in ovarian cancer dissemination. Recent studies have shown that platinum-based or PARP inhibitor therapies, standard treatments for ovarian cancer, can induce senescence in ovarian cancer cells, leading to an inflammatory response known as the senescence-associated secretory phenotype (SASP). The SASP may promote metastasis in ovarian cancer.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
Favour A. Akinjiyan, Ritu M. Dave, Emily Alpert, Gregory D. Longmore, Katherine C. Fuh
Summary: Ovarian cancer is the most fatal gynecological disease, and the research discovered that the interaction between DDR2 receptor and periostin in cancer-associated fibroblasts promotes tumor metastasis. This study is crucial for understanding the molecular mechanisms underlying ovarian cancer metastasis.
Article
Medicine, Research & Experimental
Jin Qian, Bauer L. LeSavage, Kelsea M. Hubka, Chenkai Ma, Suchitra Natarajan, Joshua T. Eggold, Yiren Xiao, Katherine C. Fuh, Venkatesh Krishnan, Annika Enejder, Sarah C. Heilshorn, Oliver Dorigo, Erinn B. Rankin
Summary: Ovarian cancer-associated mesothelial cells play a critical role in promoting chemoresistance and stemness in ovarian cancer. The secreted factor osteopontin drives mesothelial-mediated chemoresistance and stemness, and therapeutic targeting of osteopontin may enhance platinum sensitivity in ovarian cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Vipul Bhardwaj, Yan Qin Tan, Ming Ming Wu, Lan Ma, Tao Zhu, Peter E. Lobie, Vijay Pandey
Summary: Nearly 70% of ovarian cancer patients experience recurrence within the first 2 years after initial treatment. Emerging evidence suggests that long non-coding RNAs play a pivotal role in OC progression, therapy resistance and recurrent OC. Studies have reported differential expression patterns of lncRNAs in OC, which are related to increased invasion, metastasis and drug resistance.
Article
Oncology
Victor Lago, Beatriz Montero, Susana Lopez, Pablo Padilla-Iserte, Luis Matute, Tiermes Marina, Marta Gurrea, Guillermina Montoliu, Pilar Bello, Santiago Domingo
Summary: The objective of this study is to determine the role of sentinel lymph node ultrastaging in apparent early-stage ovarian cancer. The study shows that a uniform protocol for ultrastaging is essential for lower-volume metastasis detection and to provide reproducible information for future studies.
GYNECOLOGIC ONCOLOGY
(2021)