期刊
BIOSENSORS & BIOELECTRONICS
卷 141, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.111406
关键词
Electrochemical immunosensor; Poly(indole-5-carboxylic acid); Redox stability
类别
资金
- National Natural Science Foundation of China [81771974]
The high stability of redox signal is one of the most crucial factors in construction of electrochemical immunosensors. However, the redox-active species usually show low stability and poor conductivity, which inhibits their application in electrochemical immunosensors. In this work, we report that the conductive polymer poly(indole-5-carboxylic acid) (PIn-5-COOH) possesses ultra-high redox stability. The redox signal of PIn-5-COOH could remain 96.03% after 500 cyclic voltammery (CV) cycles in buffer solution with pH of 6.2, while the redox signals in most of the previous reports only remained less than 90% after 50 CV cycles. Our mechanism investigation indicated that the ultra-high redox stability of PIn-5-COOH should be attributed to its stable structure. The electrochemical immunosensors fabricated with PIn-5-COOH/MWCNTs-COOH nanocomposite showed a wide linear range from 0.001 ng mL(-1) to 100 ng mL(-1) and a low detection limit of 0.33 pg mL(-1) for the detection of alpha fetoprotein. This study opens up a new avenue for the construction of electrochemical immunosensors with ultra-stable redox signal.
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