Article
Pharmacology & Pharmacy
Qing Zhao, Xia Ren, Shu-Yue Song, Ri-Lei Yu, Xin Li, Peng Zhang, Chang-Lun Shao, Chang-Yun Wang
Summary: This study investigates the underlying mechanism of Le-Cao-Shi (LCS) in treating liver injuries. The results show that LCS can inhibit liver injuries through anti-inflammatory property, suppressing lipid peroxidation, and improving the antioxidant defense system. These findings provide important insights for further research and modernization of LCS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Qing Zhao, Shu-Yue Song, Yu-Qi Zhang, Xia Ren, Peng Zhang, Xin Li, Xiu-Mei Fu, Chang-Yun Wang
Summary: The anti-hepatitis B activities of Formula Le-Cao-Shi (LCS) and its three single herbs were investigated, and the mechanisms against hepatitis B were deciphered via network pharmacology and gut microbiota analysis. The study revealed that LCS could exert anti-hepatitis B effect by coregulating cell cycle and inflammatory pathways and restoring the disordered microbial composition.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Daoqi Zhu, Aiwu Li, Ying Lv, Qin Fan
Summary: Epigenetic modification, especially DNA methylation, plays an important role in tumor development. Traditional Chinese medicine has been shown to have an anti-tumor effect by regulating DNA methylation modification. It is a potentially reliable epigenetic drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guo-liang Bai, Kai-li Hu, Yi Huan, Xing Wang, Lei Lei, Meng Zhang, Chun-yan Guo, Hong-sheng Chang, Li-bo Zhao, Jing Liu, Zhu-fang Shen, Xiao-ling Wang, Xin Ni
Summary: This study explored the effects of the Fuyou formula on precocious puberty, suggesting that it may alleviate precocious puberty through the GPR54/GnRH signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medical Informatics
Yidi Cui, Bo Gao, Lihong Liu, Jing Liu, Yan Zhu
Summary: The research team constructed a large-scale intelligent retrieval system AMFormulaS using ontology, which efficiently retrieves and analyzes information on traditional Chinese medicine formulas and decoction pieces, providing support for scientific research and new drug development.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Review
Pharmacology & Pharmacy
Zhihua Huang, Jingyi Wang, Chun Li, Weihong Zheng, Junyuan He, Ziguang Wu, Jianbang Tang
Summary: Spinal cord injury (SCI) is a devastating disease caused by physical traumas. Oxidative stress (OS) may play a crucial role in secondary injuries, and traditional Chinese medicine (TCM) with antioxidant effects shows potential for the treatment of SCI.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Wenxing He, Canli Xu, Dewen Mao, Yang Zheng, Na Wang, Minggang Wang, Nan Mao, Ting Wang, Yanjie Li
Summary: In recent years, the incidence of liver disease has increased, becoming a major cause of death. Various liver diseases are intricately linked to pyroptosis, which is one of the most common forms of programmed cell death. Traditional Chinese medicine (TCM) is a powerful weapon in the fight against liver diseases and can affect pyroptosis through multiple pathways. This review provides an overview of pyroptosis, its interplay with liver diseases, and the mechanisms through which TCM regulates pyroptosis in liver diseases.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shuaibing He, Yanfeng Yi, Diandong Hou, Xuyan Fu, Juan Zhang, Xiaochen Ru, Jinlu Xie, Juan Wang
Summary: The efforts to discover potential hepatoprotective drugs from Traditional Chinese Medicine (TCM) are critical for alleviating the burden of liver diseases. This study established a large-scale dataset focused on TCM-induced hepatoprotection and developed an in silico model for predicting the hepatoprotective activity of ingredients derived from TCMs. The accuracy of the model exceeded 85%, demonstrating the technical soundness and reliability of the methods used.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Wing-Sum Siu, Hui Ma, Wen Cheng, Wai-Ting Shum, Ping-Chung Leung
Summary: This study investigated the effect and mechanism of action of a topical traditional Chinese medicine formula, CDR, on muscle regeneration using in vitro and in vivo experiments. The results showed that CDR was non-cytotoxic and increased cell viability. Histological analysis demonstrated that CDR treatment facilitated muscle repair by increasing the number of new muscle fibers and promoting muscle integrity. Gene expression analysis indicated that CDR treatment accelerated the regeneration and remodeling phases during muscle repair. This study highlighted the effectiveness of topical CDR treatment in facilitating muscle injury repair.
Review
Pharmacology & Pharmacy
Liu Liu, Lei Zhang, Ming Li
Summary: Lupus nephritis is a renal disease caused by systemic lupus erythematosus and has serious implications for patients. Traditional Chinese medicine has shown promising effects in alleviating the symptoms and improving the prognosis of LN patients. This review provides supplementary evidence for the development of TCM treatment for LN and serves as a reference for future research and clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Chunlei Wei, Jing Qiu, Yuyi Wu, Ziqiang Chen, Ziwei Yu, Zecheng Huang, Ke Yang, Huiling Hu, Fang Liu
Summary: This review summarizes the effective single and compound traditional Chinese medicines (TCMs) for the treatment of cholestatic liver disease (CLD). Based on the different clinical stages of CLD, the pharmacological effects and mechanisms of five promising TCM examples, including Yin Chen, Chi Shao, Fu Ling, Huang Qi Decoction (HQD), and Yin Chen Hao Decoction (YCHD), are discussed. The findings suggest that TCMs can effectively control the development of CLD and personalized treatment measures can slow down the progression of the disease.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Yue Shi, Xiujie Shi, Mingming Zhao, Meiying Chang, Sijia Ma, Yu Zhang
Summary: Acute kidney injury (AKI) is a serious health concern without effective drugs or treatments, except for renal replacement therapy. This review explores the potential of ferroptosis as a therapeutic target for AKI and highlights the role of traditional Chinese medicine (TCM) compounds in inhibiting ferroptosis to prevent and treat AKI. The findings suggest that TCM compounds have promising prospects in AKI treatment by targeting ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Gastroenterology & Hepatology
Chuting Yang, Tingting Wang, Juan Chen, Jiajun He, Yuanhao Li, Chaowu Chen, Guotao Lu, Weiwei Chen
Summary: Traditional Chinese medicine has unique advantages in treating acute pancreatitis, improving the condition of patients by regulating inflammatory responses and enhancing immunity, thereby reducing mortality rates and financial burdens.
Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Review
Integrative & Complementary Medicine
Chunzhu Wei, Jingbo Wang, Jintao Yu, Qing Tang, Xinjie Liu, Yanlong Zhang, Dandan Cui, Yanqiong Zhu, Yanli Mei, Yanjun Wang, Wenzhu Wang
Summary: Traumatic brain injury (TBI) is a major cause of disability and death, and the social burden it imposes is significant. Despite the increasing incidence of TBI due to various factors, there is currently no approved drug specifically effective for its treatment. This study analyzes the use of neuroprotective agents in animal models and clinical trials, and suggests exploring traditional Chinese medicine as a potential therapeutic strategy for TBI.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)