Different Cardiotoxicity of Palbociclib and Ribociclib in Breast Cancer: Gene Expression and Pharmacological Data Analyses, Biological Basis, and Therapeutic Implications

A current understanding of drug-induced QT prolongation and its implications for anticancer therapy

(2019) Dan M Roden   CARDIOVASCULAR RESEARCH

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro

(2018) Ales Sorf et al.   BIOCHEMICAL PHARMACOLOGY

Impact of body mass index on the efficacy of endocrine therapy in patients with metastatic breast cancer - A retrospective two-center cohort study

(2018) Luwam Zewenghiel et al.   BREAST

Management of QT prolongation induced by anti-cancer drugs: Target therapy and old agents. Different algorithms for different drugs

(2018) Carmela Coppola et al.   CANCER TREATMENT REVIEWS

LncRNA co-expression network analysis reveals novel biomarkers for pancreatic cancer

(2018) Matteo Giulietti et al.   CARCINOGENESIS

Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA

(2018) Qiuming Gong et al.   GENE

Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: MONALEESA-3

(2018) Dennis J. Slamon et al.   JOURNAL OF CLINICAL ONCOLOGY

Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial

(2018) Debu Tripathy et al.   LANCET ONCOLOGY

Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms

(2018) Joachim Alexandre et al.   PHARMACOLOGY & THERAPEUTICS

Canalopatias cardíacas: o papel das mutações nos canais de sódio

(2018) Diana João Fonseca et al.   Revista Portuguesa de Cardiologia

Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2

(2018) Li Zhang et al.   GENE

Co-expression Network Approach to Studying the Effects of Botulinum Neurotoxin-A

(2017) Kavitha Mukund et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

Tbx20 controls the expression of theKCNH2gene and of hERG channels

(2017) Ricardo Caballero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data

(2017) Christopher E. Pollard et al.   TOXICOLOGICAL SCIENCES

Identification of candidate miRNA biomarkers for pancreatic ductal adenocarcinoma by weighted gene co-expression network analysis

(2017) M. Giulietti et al.   CELLULAR ONCOLOGY

GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, “GENEREPOL study”: Lack of common variants with large effect sizes

(2017) Joe-Elie Salem et al.   PLoS One

Phase I study of palbociclib, a cyclin-dependent kinase 4/6 inhibitor, in Japanese patients

(2016) Kenji Tamura et al.   CANCER SCIENCE

Effect of Body Mass Index– and Actual Weight–Based Neoadjuvant Chemotherapy Doses on Pathologic Complete Response in Operable Breast Cancer

(2016) Rachna Raman et al.   Clinical Breast Cancer

Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer

(2016) Tommaso De Marchi et al.   DRUG DISCOVERY TODAY

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Weighted gene co-expression network analysis reveals key genes involved in pancreatic ductal adenocarcinoma development

(2016) Matteo Giulietti et al.   CELLULAR ONCOLOGY

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

(2016) Barbara Wiśniowska et al.   BMC Pharmacology & Toxicology

The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology

(2015) Nicola Detta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Pharmacogenetics of Drug-Induced QT Interval Prolongation: An Update

(2015) Maartje N. Niemeijer et al.   DRUG SAFETY

The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology

(2015) Christiaan C. Veerman et al.   GENE

Genetics of long-QT syndrome

(2015) Yukiko Nakano et al.   JOURNAL OF HUMAN GENETICS

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

Upregulation of functional Kv11.1 isoform expression by inhibition of intronic polyadenylation with antisense morpholino oligonucleotides

(2014) Qiuming Gong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MiR-133b Contributes to Arsenic-Induced Apoptosis in U251 Glioma Cells by Targeting the hERG Channel

(2014) Jian Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation

(2013) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity

(2013) Nicola Ferri et al.   PHARMACOLOGY & THERAPEUTICS

Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines

(2012) G. Curigliano et al.   ANNALS OF ONCOLOGY

Mechanisms of Endocrine Resistance in Breast Cancer

(2010) C. Kent Osborne et al.   Annual Review of Medicine

Drug-Induced Arrhythmia

(2010) E. Kevin Heist et al.   CIRCULATION

Molecular Mechanisms of Cardiovascular Toxicity of Targeted Cancer Therapeutics

(2010) Hui Cheng et al.   CIRCULATION RESEARCH

Cardiotoxicity of anticancer treatments: what the cardiologist needs to know

(2010) Michael S. Ewer et al.   Nature Reviews Cardiology