Article
Pharmacology & Pharmacy
Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bo-wen Zhou, Hua-man Liu, Xin-hua Jia
Summary: Asthma as an individual disease remains a global health challenge. Traditional Chinese Medicine (TCM) has been shown to have anti-asthma effects, but its specific role and mechanism are still unclear. Animal studies have demonstrated that TCM formulas and natural compounds can significantly alleviate airway structural alterations and exhibit anti-inflammatory effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Fen Liu, Jintao Zhang, Dong Zhang, Quin Qi, Wenjing Cui, Yun Pan, Xiaofei Liu, Jiawei Xu, Xinrui Qiao, Zihan Wang, Liang Dong
Summary: This study reveals the crucial role of the miR-200b-3p/FSTL1 axis in regulating airway remodeling and inflammation in asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Ibrahim Sulaiman, Emmanuel Oshiogwe Okwuofu, Norhafizah Mohtarrudin, Jonathan Chee Woei Lim, Johnson Stanslas
Summary: The standardized Andrographis paniculata 50% ethanol extract (APEE50) showed anti-inflammatory effects in a mouse asthma model by down-regulating Th2 cytokine gene expression and oxidative stress levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Oncology
Qin Yang, Qing Miao, Hui Chen, Duo Li, Yongfeng Luo, Joanne Chiu, Hong-Jun Wang, Michael Chuvanjyan, Michael S. Parmacek, Wei Shi
Summary: Abnormal growth of airway smooth muscle cells is a key feature in asthmatic airway remodeling. The role of Myocd, a transcriptional coactivator, in this process has been investigated in a mouse model of chronic asthma. Deletion of Myocd mitigated airway smooth muscle cell hypertrophy and hyperplasia, reduced inflammation and collagen deposition, and attenuated abnormal mucin production. Myocd could be a potential therapeutic target for treating severe and persistent asthma.
JOURNAL OF PATHOLOGY
(2023)
Review
Immunology
Ning Zhang, Jing Xu, Congshan Jiang, Shemin Lu
Summary: This review explores the neural regulation mechanisms in the occurrence of allergic asthma, covering aspects from immune response, airway remodeling to pulmonary neuroendocrine cells. Although research in this area is still limited, further investigation into neural regulation can help us better understand the mechanism of asthma comprehensively, and find more effective ways to prevent and control asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Laila Salameh, Walid Mahmood, Rifat Hamoudi, Khulood Almazrouei, Mahesh Lochanan, Suheyl Seyhoglu, Bassam Mahboub
Summary: Asthma, a common chronic respiratory disease affecting millions of people worldwide, is being increasingly linked to vitamin D deficiency. This systematic review evaluated the effects of vitamin D supplementation on airway remodeling in asthmatic patients. After a thorough search of several databases, 9 experimental studies were included, suggesting that vitamin D inhibits airway smooth muscle cell contraction and remodeling, reduces inflammation, regulates collagen synthesis in the airways, and modulates the action of bronchial fibroblasts. However, the role of TGF-beta 1 in impairing vitamin D-induced airway epithelial host defense mechanisms needs further investigation.
Article
Cell Biology
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin
Summary: This study found that the Hedgehog signaling pathway is involved in the process of airway remodeling in asthma, which is partially mediated via the PTCH1-SMO-GLI axis. This provides hope for finding new targets for treating airway tissue remodeling in patients with allergic airways disease.
Article
Multidisciplinary Sciences
Ruping Wang, Yinna Wang, Guoning Liao, Bohao Chen, Reynold A. Panettieri, Raymond B. Penn, Dale D. Tang
Summary: Asthma is a complex pulmonary disorder with multiple pathological mechanisms. A key pathological feature is airway remodeling, which is largely caused by the abnormal proliferation of airway smooth muscle cells. An adapter protein called Abi1 has been identified as a molecular switch that regulates the activation of certain proteins and contributes to the progression of asthma.
Article
Immunology
Yingshuo Wang, Xinyan Dong, Caizhe Pan, Cihang Zhu, Hantao Qi, Yifan Wang, Hao Wei, Qiangmin Xie, Lei Wu, Huijuan Shen, Shuxian Li, Yicheng Xie
Summary: In this study, a monkey model of asthma was established and analyzed using single-cell RNA sequencing. The model exhibited airway hyperresponsiveness and remodeling, with an increase in the number of various cell types. These findings provide valuable insights into the understanding of asthma pathogenesis and potential treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Harshita Shailesh, Ibrahim A. Janahi
Summary: Obesity is a significant risk factor for asthma and has a detrimental effect on the severity of the disease. It impairs lung airway function and leads to increased inflammation and severe remodeling of the bronchus. This review discusses the current research on the role of obesity in modulating airway cell functions and explores different therapeutic approaches for treating obese asthmatic individuals.
Article
Medicine, Research & Experimental
Jinmei Zhang, Zhengcan Wu, Fenfang Yu, Liang Ye, Wei Gu, Yan Tan, Li Wang, Ying Shi
Summary: The research found that LXRs can increase airway inflammation and hyperresponsiveness, as well as promote airway remodeling, suggesting that inhibiting LXRs may be a potential method for treating allergic asthma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Qiujie Wang, Luna Hong, Ming Chen, Jiangting Shi, Xiaoling Lin, Linjie Huang, Tiantian Tang, Yimin Guo, Xiaoqing Yuan, Shanping Jiang
Summary: The miR-378a-3p/GRB2 pathway regulates the polarization of alveolar macrophages in asthma, suggesting a potential therapeutic target for airway inflammation and remodeling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Immunology
Bin Huang, Ming Liu, Gaozhong Le
Summary: This study explores a novel ceRNA mechanism involving LINC1810064F22Rik that is related to asthma-induced allergic inflammation and airway remodeling. It predicts differentially expressed lncRNAs and downstream effectors using bioinformatics analysis, and validates the targeting relationship between LINC1810064F22Rik, miR-206-5p, and HDAC4 through experimental assays. In vivo and in vitro experiments demonstrate the role of LINC1810064F22Rik/miR-206-5p/HDAC4 axis in promoting allergic inflammation and airway remodeling. The findings provide valuable insights into the understanding of asthma pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)