Review
Cell Biology
Chao-Fan Lu, Ya-Nan Zhou, Jingjing Zhang, Songxue Su, Yupeng Liu, Guang-Hua Peng, Weidong Zang, Jing Cao
Summary: Photoreceptors play a crucial role in the retina by converting light into electrical signals. Epigenetics, specifically DNA methylation and histone modification, regulates the development, differentiation, degeneration, and pathological processes of photoreceptors. Understanding the role of methylation/demethylation in regulating photoreceptors in various physiological and pathological situations is essential for understanding retinal diseases and developing novel therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Martin Montecino, Margarita E. Carrasco, Gino Nardocci
Summary: Genomic DNA in the eukaryotic nucleus is organized into chromatin through stable interactions with histone proteins and other nuclear components, contributing to differential control of access to key genetic information. Epigenetic mechanisms, such as DNA methylation and chromatin remodeling, play critical roles in regulating gene expression by modifying chromatin compaction levels for transcription activation and repression. The review discusses evidence supporting the role of these mechanisms in the transcriptional control of osteoblast-related genes, particularly at the Runx2 and Sp7 genes, which encode master regulators of osteogenic lineage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Lemeng Feng, Chao Wang, Cheng Zhang, Wulong Zhang, Weitao Song
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, and lowering intraocular pressure is currently the only effective clinical treatment. However, there is a lack of long-acting drugs to lower intraocular pressure, and some patients still experience loss of retinal ganglion cells despite good control of intraocular pressure. Currently, there are no effective clinical methods for neuroprotection and regeneration in glaucoma. Recent studies have shown that epigenetics plays a crucial role in neuroprotection and regeneration in glaucoma.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Shihang Zhou, Hongliang Zeng, Jinhua Huang, Li Lei, Xiaoliang Tong, Si Li, Ying Zhou, Haoran Guo, Manal Khan, Liping Luo, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Melanogenesis is a complex process involving multiple genes and signaling pathways, with epigenetics playing a key role in regulating the expression of key genes. Epigenetic-based therapy provides novel opportunities for treating dermatoses caused by pigmentation disturbances.
AGEING RESEARCH REVIEWS
(2021)
Review
Plant Sciences
Jie Liu, Meng Ke, Yuhan Sun, Shihui Niu, Wenli Zhang, Yun Li
Summary: Plant rejuvenation involves resetting gene expression patterns, chromatin remodeling, and histone modifications, resulting in the restoration of juvenile characteristics. The epigenetic mechanisms underlying this process are still in the early stages of study.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Rachel J. Kehrberg, Namita Bhyravbhatla, Surinder K. Batra, Sushil Kumar
Summary: Cancer-associated fibroblasts (CAFs), a significant component of the tumor microenvironment (TME), contribute to cancer progression through the secretion of extracellular matrix (ECM), growth factors, and metabolites. It is now well recognized that CAFs are a heterogenous population with ablation experiments leading to reduced tumor growth and single-cell RNA sequencing demonstrating CAF subgroups. CAFs lack genetic mutations yet substantially differ from their normal stromal precursors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemistry & Molecular Biology
XiaoDong Jin, WenYe Liu, Jing Miao, ZhiPeng Tai, LingYa Li, PengPeng Guan, Jing-Xia Liu
Summary: The study shows that disrupted Cu2+ homeostasis can lead to developmental defects in zebrafish myogenesis, possibly through regulating gene promoter methylation and histone modification to affect signaling transduction pathways.
Review
Immunology
Chao Yang, Dan Li, Dehong Teng, Yueru Zhou, Lei Zhang, Zhangfeng Zhong, Guan-Jun Yang
Summary: This review discusses the research on the pathogenesis of rheumatoid arthritis (RA) in the past five years based on epigenetic modifications, providing new methods and strategies for the diagnosis and treatment of this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yunkai Yang, Yan Wang
Summary: The tumor immune microenvironment (TIME) is crucial in the development, progression, and immune escape of various cancers. Epigenetic alterations can reprogram immune cells in TIME, while the gut microbiome can also influence colorectal cancer and extraintestinal tumors. Tumors are heterogeneous diseases regulated by genetics and epigenetics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Maria J. Klomp, Julie Refardt, Peter M. van Koetsveld, Claudia Campana, Simone U. Dalm, Fadime Dogan, Marie-Louise F. van Velthuysen, Richard A. Feelders, Wouter W. de Herder, Johannes Hofland, Leo J. Hofland
Summary: This study found that DNA methylation and histone modifications are associated with SST2 expression in SI-NETs. DNA methylation levels and H3K27me3 levels were lower in SI-NETs compared to normal tissue, and there was a negative correlation between SST2 mRNA expression level and DNA methylation. However, the role of histone modifications in SI-NETs remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Heng Wee Tan, Yan-Ming Xu, San-Hai Qin, Guo-Feng Chen, Andy T. Y. Lau
Summary: Lung cancer is the leading cause of cancer-related deaths worldwide, with angiogenesis playing a crucial role in the growth and metastasis of lung cancer cells. While genetic regulation of angiogenesis in lung cancer is extensively studied, relatively less is known about the epigenetic regulation. Epigenetic alterations, including DNA epimodifications, histone posttranslational modifications, and noncoding RNA expression, contribute to regulating angiogenesis in lung cancer. In the future, epigenetic-based therapy is likely to emerge as a prominent approach for treating lung cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Adolfo B. Frias, Shannon K. Boi, Xin Lan, Ben Youngblood
Summary: The concept of adaptive immunity, based on immunological memory, has paved the way for modern vaccination and immunotherapy. Recent studies have identified epigenetic programs as a molecular mechanism governing T cell subset specification and immunological memory.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Oncology
Judy S. Crabtree
Summary: Gastroenteropancreatic neuroendocrine neoplasms are rare and diverse tumors associated with genetic disorders and epigenetic regulation. Epigenetic signatures can be used as biomarkers for diagnosis and as targets for the development of new treatment approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)