Review
Immunology
Pan Shen, Xuan Deng, Zhe Chen, Xin Ba, Kai Qin, Ying Huang, Yao Huang, Tingting Li, Jiahui Yan, Shenghao Tu
Summary: SIRT1, as a member of the class III family of nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylases, plays a crucial role in the progression of various diseases, including autoimmune diseases. Modulating the functions of SIRT1 may serve as a potential therapeutic strategy for these diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Abtar Mishra, Assirbad Behura, Ashish Kumar, Lincoln Naik, Ashapoorna Swain, Mousumi Das, Suman Sudha Sarangi, Puja Dokania, Vijaya R. Dirisala, Sujit K. Bhutia, Amit Mishra, Ramandeep Singh, Rohan Dhiman
Summary: The P2X7 receptor is a key player in various physiological processes and has been directly associated with several pathophysiological conditions. Understanding its structure and downstream signaling processes is considered a promising approach to alleviate the afflictions associated with disorders like cancer, diabetes, arthritis, tuberculosis, and inflammatory diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Sha-Sha Tao, Fan Cao, Napoleon Bellua Sam, Hong-Miao Li, Ya-Ting Feng, Jing Ni, Peng Wang, Xiao-Mei Li, Hai-Feng Pan
Summary: DKK-1 is known for inhibiting classic Wnt signaling pathways in bone formation and metastasis, but recent studies have shown its roles in bone resorption, immune homeostasis, inflammation, and autoimmune diseases. Research suggests DKK-1 could be a biomarker for autoimmune diseases and a potential treatment target.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Xiaochun Ye, Yongxia Zhao, Wanqing Ma, Irma Ares, Marta Martinez, Bernardo Lopez-Torres, Maria-Rosa Martinez-Larranaga, Xu Wang, Arturo Anadon, Maria-Aranzazu Martinez
Summary: CD38 is a multifunctional cell surface protein involved in NAD+ homeostasis and can be found in various immune and non-immune cells. It plays an important role in regulating innate immunity and has been implicated in autoimmune diseases such as RA, SLE, MS, T1D, and inflammatory bowel disease. This report discusses the immunological functions of CD38 and recent advances in its role in the development and pathogenesis of autoimmune diseases, as well as its potential as a therapeutic target for systemic diseases.
AUTOIMMUNITY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Xie Saiyang, Deng Wei, Tang Qizhu
Summary: SIRT6, a member of the Sirtuin family, plays a crucial role in regulating biological homeostasis, longevity, and disease prevention, particularly in the occurrence and development of various cardiovascular diseases. Recent research has identified SIRT6 as a key intervention target for heart failure, cardiovascular remodeling, and atherosclerosis, bringing it to the forefront of clinical interest.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Physiology
Guangxin Peng, Xiaoling Tang, Yang Gui, Jing Yang, Lifang Ye, Liuyang Wu, Ya Hui Ding, Lihong Wang
Summary: TRPV1 plays a significant role in fibrotic diseases, regulating the fibrotic processes and potentially serving as a therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Geriatrics & Gerontology
Li-Ping Jiang, Xiao-Hua Yu, Jin-Zhi Chen, Mi Hu, Yang-Kai Zhang, Hui-Ling Lin, Wan-Ying Tang, Ping-Ping He, Xin-Ping Ouyang
Summary: Atherosclerosis, the main pathological basis of cardiovascular diseases, involves plaque formation in blood vessels and HDAC3 has been found to play critical roles in regulating vascular function, cell migration, foam cell formation, and more in the disease process.
Review
Medicine, Research & Experimental
Jordi Olloquequi, Amanda Cano, Elena Sanchez-Lopez, Marina Carrasco, Ester Verdaguer, Ana Fortuna, Jaume Folch, Monica Bullo, Carme Auladell, Antoni Camins, Miren Ettcheto
Summary: PTP1B is a potential target for the treatment of neurological diseases, as its activation in brain cells can lead to various neuronal deficits. However, inhibition of PTP1B has shown promising therapeutic effects and potential to improve cognitive processes. Clinical trials evaluating the neurological benefits of PTP1B inhibition are still needed.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Kripa Jain, Kalyani Barve, Lokesh Kumar Bhatt
Summary: This review summarizes the physiological roles and signal transduction of gasdermins and highlights their significance in pathological conditions such as autoimmune diseases, kidney diseases, and central nervous system diseases.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2022)
Article
Neurosciences
Emily Zucker, Irina Burd
Summary: Inflammation-induced preterm birth is a major cause of perinatal mortality and long-term consequences in surviving children. IL-10 and the P2X7 receptor play crucial roles in this process, with the receptor potentially being a therapeutic target to halt inflammation before perinatal brain injury.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andre D. J. Mckenzie, Taylor R. Garrett, Eryn L. Werry, Michael Kassiou
Summary: This review summarizes the current understanding of amyotrophic lateral sclerosis (ALS), the role of purinergic P2X(7) receptor (P2X(7)R) in ALS, the current landscape of P2X(7)R antagonists, and their potential in preclinical ALS models.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Cell Biology
Maria Galindo-Izquierdo, Jose Luis Pablos Alvarez
Summary: The complement system, consisting of more than 50 proteins, plays a key role in recognizing and protecting against foreign or damaged molecular components. Pathological activation of the complement system is involved in the pathogenesis of autoimmune diseases, and it may serve as a potential therapeutic target in rheumatologic autoimmune processes.
Review
Immunology
Shihan Xu, Tingwei Zhang, Zhengguo Cao, Wenjie Zhong, Chuangwei Zhang, Han Li, Jinlin Song
Summary: Integrin-alpha 9 beta 1 is a crucial cell membrane receptor with complex signaling pathways. It plays important roles in regulating cell physiological states and is involved in various diseases such as cancer, autoimmune diseases, nerve injury, and thrombosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jiaqi Kang, Jie Wu, Qinjie Liu, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: This review discusses the importance of STING in immune responses and its role in disease pathogenesis when over-activated. The focus is on post-translational modifications that regulate the activation and inhibition of STING, and their potential as targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2022)