Review
Immunology
Panida Sittipo, Jaeyoon Choi, Soojin Lee, Yun Kyung Lee
Summary: This review highlights the importance of microbiota in regulating gut-brain communication in immune-related neurological disorders. The bidirectional communication between gut microbiota and the brain affects human health and behavior, particularly in neurological disorders. Despite numerous studies, there are still limitations in translating this research to humans.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Microbiology
Shokufeh Ghasemian Sorboni, Hanieh Shakeri Moghaddam, Reza Jafarzadeh-Esfehani, Saman Soleimanpour
Summary: The human microbiome, consisting of bacteria, viruses, and fungi, plays a central role in the development of the immune system, the central nervous system, and the gastrointestinal tract. Imbalance in the gut microflora is associated with neurological disorders. Microbiome-based therapies show promise in treating these disorders.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Katarzyna Socala, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Wlodarczyk, Anna Zielinska, Ewa Poleszak, Jakub Fichna, Piotr Wlaz
Summary: Emerging evidence suggests that gut microbiota play a crucial role in the bidirectional communication between the gut and brain, influencing neural development, neurotransmission, and behavior. Studies have explored the role of microbiota in various neuropsychiatric and neurological disorders, including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. This review discusses data from both preclinical experiments and clinical reports, highlighting the effects of probiotic, prebiotic, or antibiotic treatments, as well as fecal microbiota transplantation.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Neurosciences
Hanif Ullah, Safia Arbab, Yali Tian, Chang-qing Liu, Yuwen Chen, Li Qijie, Muhammad Inayat Ullah Khan, Inam Ul Hassan, Ka Li
Summary: The gut microbiota has a significant impact on the host's physiology and pathology, communicating with different organs through hormone synthesis and regulation of body activity. Dysbiosis in the gut microbiota leads to gastrointestinal disorders that affect host physiology through abnormal microbial metabolites. This dysbiosis alters the bidirectional relationship between the central nervous system and gut microbiota, contributing to the pathogenesis of neurodevelopmental and neurological disorders. Increasing evidence suggests that gut microbes may play a role in the progression of neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and autism spectrum disorder.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Prabhakar Tiwari, Rekha Dwivedi, Manisha Bansal, Manjari Tripathi, Rima Dada
Summary: The gut microbiota (GM) plays a significant role in human metabolism, immune system, and neurological disorders. It interacts with the gastrointestinal tract and contributes to the gut-brain axis (GBA) through bidirectional transmission. The GM can be regulated and supplemented with prebiotics, probiotics, postbiotics, synbiotics, fecal transplantations, and antibiotics to treat neurological disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Geriatrics & Gerontology
Zi-Han Geng
Summary: The GI tract plays a crucial role in maintaining the stable intestinal microenvironment and its microbiota may have potential impacts on neurological diseases. However, the causal relationship between microbial changes and neurological disorders remains inconclusive at present.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Zhuoxin Li, Jie Zhou, Hao Liang, Li Ye, Liuyan Lan, Fang Lu, Qing Wang, Ting Lei, Xiping Yang, Ping Cui, Jiegang Huang
Summary: This study systematically reviewed the relationship between the alpha diversity of the gut microbiota and neurological diseases. The findings suggest that alpha diversity of the gut microbiota could be a promising predictor for certain neurological diseases such as AD, schizophrenia, and MS.
FRONTIERS IN NEUROSCIENCE
(2022)
Editorial Material
Medicine, General & Internal
Muh-Shi Lin, Yao-Chin Wang, Wei-Jung Chen, Woon-Man Kung
Summary: The central nervous system (CNS) acts as an immune privileged site, protected by specialized immune glial cells and the blood-brain barrier (BBB). However, neuroinflammatory responses, triggered by dysbiosis in the gut microbiota, can lead to alterations in BBB permeability, recruiting peripheral immune cells and amplifying neuroinflammatory circuits in the brain, thus causing specific neurological disorders. Aggressive treatment strategies for gastrointestinal disorders can potentially protect against immune responses and have protective effects in the CNS. This study investigates the mutual effects of microbiota and the gut-brain axis, providing potential targeting strategies for future disease treatment.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Nutrition & Dietetics
Malgorzata Anna Marc, Rafal Jastrzab, Jennifer Mytych
Summary: This article summarizes the latest knowledge on the correlation between gut microbiota dysbiosis and neurodegenerative and brain-related diseases such as Alzheimer's and Parkinson's. It emphasizes the importance of gut-derived metabolites and gut metabolic status as key factors in gut-brain crosstalk and their impact on the severity of neural conditions.
Article
Immunology
Jibran Sualeh Muhammad, Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Summary: The interaction between gut microbiota and the nervous system plays a crucial role in the pathophysiology of neurological diseases, possibly through gut bacterial metabolite-induced epigenetic modulations of neurodegenerative disorders. Advances in epigenetic techniques hold promise for unraveling the epigenetic mechanisms of the gut-brain axis.
Review
Medicine, General & Internal
Katarzyna Stopinska, Maria Radziwon-Zaleska, Izabela Domitrz
Summary: The central nervous system (CNS) and the gastrointestinal tract are closely linked, with gut flora playing a vital role in the pathogenesis of neurological and neuropsychological disorders. The microbiota-gut-brain axis provides bidirectional communication between these systems, affected by factors such as age, diet, and antibiotics, which may influence the development of neurodegenerative diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Carlo Romano Settanni, Gianluca Ianiro, Stefano Bibbo, Giovanni Cammarota, Antonio Gasbarrini
Summary: This article discusses the role of gut microbiota in maintaining central and peripheral functions as well as mental health, and the association between dysbiosis and psychiatric disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Plant Sciences
Maciej Korczak, Maciej Pilecki, Sebastian Granica, Aleksandra Gorczynska, Karolina A. Pawlowska, Jakub P. Piwowarski
Summary: Clinical research has identified promising herbal medicines for the treatment of mild mood disorders, but the active constituents are still unclear. The role of the microbiota-gut-brain axis offers new possibilities for treatment and prevention.
Article
Health Care Sciences & Services
Luigi Donato, Simona Alibrandi, Concetta Scimone, Andrea Castagnetti, Giacomo Rao, Antonina Sidoti, Rosalia D'Angelo
Summary: Analysis of microbiota from TMAU patients and mentally ill controls showed alterations in certain bacterial families that may lead to excessive release of neurotransmitters, causing a wide spectrum of psychiatric disorders. These metabolites are also related to TMA accumulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Thais Martins-Silva, Angelica Salatino-Oliveira, Julia Pasqualini Genro, Fernando D. T. Meyer, Yan Li, Luis Augusto Rohde, Mara Helena Hutz, Luciana Tovo-Rodrigues
Summary: The study found that certain genetic variants are associated with psychiatric disorders, especially schizophrenia, suggesting that genes related to microbiome composition may affect individual susceptibility to these disorders. Associations with ASD, ADHD, and MDD, while less robust, cannot be entirely dismissed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biotechnology & Applied Microbiology
Marek Konop, Marek Radkowski, Marta Grochowska, Karol Perlejewski, Emilia Samborowska, Marcin Ufnal
Article
Nutrition & Dietetics
Klaudia Bielinska, Marek Radkowski, Marta Grochowska, Karol Perlejewski, Tomasz Huc, Kinga Jaworska, Daisuke Motooka, Shota Nakamura, Marcin Ufnal
Review
Neurosciences
Marta Grochowska, Marcin Wojnar, Marek Radkowski
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2018)
Review
Immunology
Marta Grochowska, Karol Perlejewski, Tomasz Laskus, Marek Radkowski
Summary: Disturbances in gastrointestinal microbiota could significantly contribute to the development of GI cancers, with some bacteria facilitating carcinogenesis while others potentially acting as protective factors. Helicobacter pylori, Escherichia coli, and Porphyromonas gingivalis are likely causative factors in the oncogenesis of pancreatic and colorectal cancers.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Marcin Ufnal, Klaudia Bielinska, Marek Konop, Marek Radkowski, Marta Grochowska, Karol Perlejewski, Tomasz Huc, Daisuke Motooka, Shota Nakamura
