期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 64, 期 4, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00948-19
关键词
carbapenem resistance; CRKP; NDM-1; OXA-232; ST14; ST2497; carbapenemase coproduction; cefiderocol
We report here a fatal case of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections in a renal transplant patient without a travel history in the prior year, from whom 2 genetically different CRKP (sequence type 14 [ST14] and ST2497) strains carrying the same plasmids and antimicrobial resistance genes, including bla(NDM-1), bla(OXA-232), bla(CTX-M-15), armA, and ret(D), were isolated from blood and the abdominal cavity. The isolates were susceptible to colistin, tigecycline, eravacycline, and cefiderocol, which was used to treat the CRKP in combination with ceftazidime-avibactam and polymyxin B and resulted in bacterial clearance. Despite the aggressive treatment, the patient died of ischemic colitis and multiorgan failure.
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