Review
Pharmacology & Pharmacy
Marina R. Wylie, D. Scott Merrell
Summary: Azadirachta indica, or neem tree, has been traditionally used to treat human ailments and is recognized for its broad-spectrum antimicrobial activities. Recent studies suggest that neem may serve as an untapped source of novel therapeutics, particularly in addressing drug-resistant pathogens and biofilm-forming organisms. Further research is needed to explore the specific mechanisms of action, clinical efficacy, and safety of neem as a potential treatment for human pathogens.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Paper & Wood
Lulu Chang, Yin Liu, Weiwei Zhang, Guoqi Xu, Lihai Wang, Wenxia Yuan
Summary: The antifungal activities of neem seed extract against Trametes versicolor and Gloeophyllum trabeum were investigated. The extract showed inhibitory effects on fungal growth and caused severe damage to fungal hyphae. The chemical analysis identified several compounds in the extract. Moreover, the neem seed extract displayed potential for protecting wood from fungal infections.
Article
Environmental Sciences
C. E. Ouedraogo, K. N. Aboua, D. B. Soro, M. Diarra, L. Meite, K. S. Traore, K. Mamadou
Summary: This study focused on determining the physical and chemical characteristics of activated carbons produced from neem bark, using phosphoric acid as the activating agent. Results showed that the activated carbons had high specific surface areas and acidic nature, making them suitable for water treatment applications.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2021)
Article
Energy & Fuels
Sandeep P. Shewale, Miraj Kapadia, Virendra K. Rathod
Summary: The current study focused on the ultrasound-assisted extraction of total phenolic compounds from Neem leaves powder. By optimizing various process parameters, the highest yield of phenolic compounds was obtained under specific conditions. The experimental outcomes showed that ultrasound-assisted extraction was more efficient and time-saving compared to traditional methods. The Peleg's mathematical model successfully predicted the extraction values and demonstrated a good fit with experimental results.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2022)
Review
Plant Sciences
Shashank M. Patil, Prithvi S. Shirahatti, Chandana V. B. Kumari, Ramith Ramu, Nagendra M. N. Prasad
Summary: This review summarizes the efficiency of Azadirachta indica A. Juss. treatment as a contraceptive based on scientific studies. It was found that the phytochemicals from neem possess remarkable contraceptive abilities, but the specific mechanism of action remains unclear. Further clinical studies are needed to prove the efficacy of A. indica as a herbal contraceptive.
Article
Energy & Fuels
Colbert Babe, Dieudonne Kaoga Kidmo, Ahmat Tom, Rachel Raissa Ngono Mvondo, Bernard Kola, Noel Djongyang
Summary: Experimental results show that adding neem fibers to adobes improves their mechanical, thermal, and durability properties, with leaves neem fibers contributing to thermal comfort but potentially reducing durability. Overall, adobes reinforced with neem fibers are suitable as building materials with substantial thermal comfort and environmental benefits.
Article
Agriculture, Multidisciplinary
Kangxin Hou, Wantong Yu, Xiaojiao Wang, Jiarou Liu, Yan Liu, Jia Liu, Xinyao Su, Xiaoli Zhang, Qiang Xue, Caixia Wang
Summary: This study confirmed the involvement of the AiCYP71CD2 gene in the biosynthesis of Azadirachtin, and achieved mass production of dihydroniloticin through optimization of catalytic efficiency and construction of a yeast strain.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Engineering, Chemical
Francisco Simao Neto, Maria Melo Neta, Ana Sousa, Luana Damasceno, Bruna Sousa, Samuel Medeiros, Rafael Melo, Ada Lopes, Jose Santos, Maria Rios
Summary: The energetic potential of the seed shell of the Neem plant was investigated using various analytical techniques, and the results showed its suitability as a biofuel due to its composition and thermal behavior. The XRF analysis further revealed the presence of several essential elements in the seed shell.
Article
Engineering, Electrical & Electronic
Neetu Sharma, Karamvir Singh, C. C. Tripathi, M. K. Bera
Summary: The use of naturally produced biomaterials in bioelectronics addresses long-term demands. Natural biomaterial-based memristors have potential applications due to their sustainability, non-toxicity, degradability, and biocompatibility. In this study, a biomaterials-inspired thin film was successfully synthesized from neem leaf extract for biomemristor applications. The neem thin film showed high transparency and various physiochemical characteristics were investigated. The fabricated biomemristor demonstrated desirable resistance switching properties and a feasible conduction mechanism. Neem was also proven to be a temporary and eco-friendly non-volatile memory device.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Integrative & Complementary Medicine
Kartik Chandra Guchhait, Tuhin Manna, Manas Barai, Monalisha Karmakar, Sourav Kumar Nandi, Debarati Jana, Aditi Dey, Suman Panda, Priyanka Raul, Anuttam Patra, Rittwika Bhattacharya, Subhrangsu Chatterjee, Amiya Kumar Panda, Chandradipa Ghosh
Summary: Neem seed extracts, both unripe and ripe, showed strong antibiofilm, antibacterial, and anticancer activities, with the ripe seed extract exhibiting higher activity. The antibacterial activity was found to be more effective against Staphylococcus aureus (gram-positive) compared to Vibrio cholerae (gram-negative).
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Veterinary Sciences
Ahmed Gareh, Dalia Hassan, Asmaa Essa, Saber Kotb, Mohammed Karmi, Abou El-Hamd H. Mohamed, Abeer Mousa Alkhaibari, Elzahara Elbaz, Nagwa M. Elhawary, Eman A. A. Hassanen, Maha S. Lokman, Fatma A. El-Gohary, Ehab Kotb Elmahallawy
Summary: This study investigated the acaricidal activity of neem seed extracts on camel ticks and found that the hexane extract was the most effective in killing the ticks. It can be used economically for controlling H. dromedarii ticks.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Rajesh Kumar Pathak, Do-Young Kim, Byeonghwi Lim, Jun-Mo Kim
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) is a global health problem for pigs, causing significant losses to the swine industry. Vaccines are ineffective in providing long-term protection, necessitating the development of effective and safe strategies to combat the virus. This study targeted specific proteins involved in PRRSV infection and disease development to identify multi-target antiviral compounds. Through molecular docking and analysis, three compounds were selected based on their binding energy and multi-target inhibitory nature. Further analysis through pharmacokinetics, toxicity assessment, molecular dynamics simulation, and binding free energy estimation confirmed the potential of these compounds as lead compounds for natural drug development against PRRSV. If validated in clinical studies, these compounds can be used individually or in combination for effective treatment against the virus.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Physical
Sarah B. Ulaeto, Gincy Marina Mathew, Jerin K. Pancrecious, P. R. Rajimol, Akhil S. Karun, T. P. D. Rajan
Summary: This study investigated the active anticorrosion performance of epoxy coatings containing encapsulated crude vegetal extracts of Azadirachta indica leaves to protect aluminum alloy 6061 in seawater. The hybrid coatings exhibited better anticorrosion via extrinsic self-healing in alkaline chloride solution.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Energy & Fuels
Thota S. S. Bhaskara Rao, S. Murugan
Summary: This experimental study investigates the performance of an evacuated U-tube solar collector (ETSC) combined with an indirect solar dryer for drying neem leaves. It compares the results with conventional open sun drying (OSD) and finds that the ETSC dryer reduces moisture content more efficiently in 7 hours compared to the OSD in 13 hours. Various mathematical models are used to describe the drying behavior of neem leaves, and the most suitable fit is determined. Quality analysis shows that the leaves dried by the ETSC have higher total phenolic content and fewer pores in their microstructure compared to OSD-dried leaves. XRD analysis indicates that ETSC-dried neem leaves have a longer shelf life, and FTIR analysis suggests their suitability for drug production in the pharmaceutical industry.
Article
Chemistry, Physical
G. Dhinagaran, G. Vijayakumar, S. Prashanna Suvaitha, G. Harichandran, K. Venkatachalam
Summary: Conversion of non-edible oils to biodiesel is an important alternative, and the use of SBA-15 supported sulphated zirconia catalyst (SO42-/ZrO2(5,10,15 wt%)/SBA-15) shows promising results in the transesterification of neem oil.
