Article
Endocrinology & Metabolism
C. Brent Wakefield, Vanessa R. Lee, Danielle Johnston, Parastoo Boroumand, Nicolas J. Pillon, Samar Sayedyahossein, Brooke L. O'Donnell, Justin Tang, Rafael E. Sanchez-Pupo, Kevin J. Barr, Robert Gros, Lauren Flynn, Nica M. Borradaile, Amira Klip, Frank Beier, Silvia Penuela
Summary: PANX3 expression in male adult mouse adipose tissue may regulate adipocyte numbers, influencing fat accumulation and inflammation. Male KO mice fed a chow diet had lower body weight and lower fat mass, reduced to the same extent as WT mice with forced exercise, suggesting a potential role of PANX3 in regulating body weight. Additionally, KO mice exhibited a more anti-inflammatory phenotype on a high-fat diet compared to WT mice, with significantly lower expression of multiple pro-inflammatory genes in white adipose tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
Agnieszka Nikolajuk, Magdalena Stefanowicz, Marek Straczkowski, Monika Karczewska-Kupczewska
Summary: This study aimed to assess the expression of genes involved in the Hippo signaling network in subcutaneous adipose tissue (SAT) of overweight or obese individuals after dietary intervention (DI) in relation to obesity and insulin sensitivity. The results showed that the upstream effectors of the Hippo pathway were downregulated in SAT of obese individuals, and DI improved adipogenic capacity.
JOURNAL OF NUTRITION
(2023)
Review
Endocrinology & Metabolism
Natja Launbo, Emilie H. Zobel, Bernt Johan von Scholten, Kristine Faerch, Peter G. Jorgensen, Regitse H. Christensen
Summary: This systematic review and meta-analysis found that exercise, diet, bariatric surgery, and pharmaceutical interventions can reduce cardiac adipose tissue volume. The study included 34 studies, with evidence supporting the effectiveness of these interventions.
Article
Endocrinology & Metabolism
J. A. Henry, I. Abdesselam, O. Deal, A. J. Lewis, J. Rayner, M. Bernard, A. Dutour, B. Gaborit, F. Kober, A. Soghomonian, B. Sgromo, J. Byrne, T. Bege, S. Neubauer, B. A. Borlaug, O. J. Rider
Summary: Obesity affects cardiac geometry, causing both eccentric and concentric remodelling. Following bariatric surgery, these processes should be reversed. This study investigated the changes in adipose depots and cardiac geometry following bariatric surgery using serial imaging.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Vanessa Rodrigues Vilela, Nolwenn Samson, Renato Nachbar, Lia Rossi Perazza, Gabriel Lachance, Volatiana Rokatoarivelo, Carolina Centano-Baez, Patricia Zancan, Mauro Solo-Penna, Kerstin Bellmann, Vincenzo Di Marzo, Mathieu Laplante, Andre Marette
Summary: This study demonstrates the crucial role of adipocyte NOS2 in the development of obesity-linked insulin resistance and dyslipidemia, partly through NO-dependent inhibition of BAT mitochondrial bioenergetics.
MOLECULAR METABOLISM
(2022)
Review
Nutrition & Dietetics
Anders Thorell
Summary: Surgery-induced weight loss can improve metabolism in obese individuals, with factors such as low calorie intake, rerouting of nutrients, and reduction of adipose tissue mass playing important roles. Increased lipolytic activity in visceral adipose tissue is associated with metabolic risk, while reduction of fat cell size may help improve insulin sensitivity.
CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Prapimporn Chattranukulchai Shantavasinkul, Hataikarn Nimitphong
Summary: The effects of vitamin D on adipose tissue biology and modulation in human obesity are still inconclusive. While the anti-inflammatory effects of vitamin D are evident and consistent, its effects on adipocyte differentiation, adipogenesis, energy metabolism, and adipokine levels remain uncertain.
Article
Nutrition & Dietetics
Marek Straczkowzk, Magdalena Stefanowicz, Agnieszka Nikolajuk, Monika Karczewska-Kupczewska
Summary: The aim of this study was to analyze the expression of subcutaneous adipose tissue circadian genes as they relate to obesity and insulin sensitivity before and after diet-induced weight loss. The study found that the expression of circadian genes was lower in individuals who were overweight/obese compared to those with normal weight, and this expression increased after weight loss. The expression of certain circadian genes, NR1D2 and DBP, was specifically associated with insulin action.
Article
Endocrinology & Metabolism
Natalia A. Gonzaga, Wanessa M. C. Awata, Sabrina P. Ficher, Victor O. Assis, Juliano Alves, Rita C. Tostes, Carlos R. Tirapelli
Summary: The study demonstrated that melatonin could restore the anticontractile effect of PVAT in obesity by reducing ROS levels, increasing SOD activity, and improving NO bioavailability.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Physiology
Aneesh Dhore-patil, Tariq Thannoun, Rohan Samson, Thierry H. Le Jemtel
Summary: This article discusses the pathophysiology and therapeutic advances in the obese-diabetic phenotype of heart failure with preserved ejection fraction.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tim Hropot, Rok Herman, Andrej Janez, Luka Lezaic, Mojca Jensterle
Summary: Adipose tissue includes white, brown, and beige adipose tissue. White adipose tissue (WAT) accumulation due to obesity is associated with inflammation, insulin resistance, and cardiometabolic risk. GLP-1 receptor agonists (GLP-1RAs) can reduce visceral and ectopic fat in WAT, leading to weight loss and improved cardiometabolic health. Understanding the role of brown adipose tissue (BAT) in weight management and investigating the impact of GLP-1RAs on BAT activation is crucial for further advancements in obesity treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Anna-Claire Pilkington, Henry A. Paz, Umesh D. Wankhade
Summary: Adipose tissue is classified based on its characteristics, but differentiating beige adipose tissue (BeAT) remains a challenge. Recent research focuses on identifying different types of adipose tissue through transcript markers to advance understanding of their biology. The development of concrete strategies to distinguish types of adipose tissue may be crucial for improving metabolic health and preventing excessive weight gain.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Tian Xiao, Laurens van Kleef, M. Kamran Ikram, Robert De Knegt, M. Arfan Ikram
Summary: The study found no significant association between nonalcoholic fatty liver disease (NAFLD) and fibrosis with an increased risk for incident dementia among the elderly. In fact, NAFLD was even protective in the first 5 years of follow-up before dementia onset.
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Camilla Bean, Matteo Audano, Tatiana Varanita, Francesca Favaretto, Marta Medaglia, Marco Gerdol, Lena Pernas, Fabio Stasi, Marta Giacomello, Stephanie Herkenne, Maheswany Muniandy, Sini Heinonen, Emma Cazaly, Miina Ollikainen, Gabriella Milan, Alberto Pallavicini, Kirsi H. Pietilainen, Roberto Vettor, Nico Mitro, Luca Scorrano
Summary: The study demonstrates that the mitochondrial cristae biogenesis protein Opa1 plays a role in cell-autonomous adipocyte browning through the regulation of the urea cycle. The findings suggest a potential therapeutic strategy for obesity and highlight the connection between the urea cycle and adipocyte browning.
Meeting Abstract
Cardiac & Cardiovascular Systems
Mohammad Monib Iqbal, Hayley J. Bennett, Bernard Davenport, Charlotte Bussey, Elizabeth Cartwright, Ashraf Kitmitto
Article
Multidisciplinary Sciences
Sarah B. Withers, Ruth Forman, Selene Meza-Perez, Daniel Sorobetea, Kasia Sitnik, Thomas Hopwood, Catherine B. Lawrence, William W. Agace, Kathryn J. Else, Anthony M. Heagerty, Marcus Svensson-Frej, Sheena M. Cruickshank
SCIENTIFIC REPORTS
(2017)
Article
Hematology
Sophie N. Saxton, Katie E. Ryding, Robert G. Aldous, Sarah B. Withers, Jacqueline Ohanian, Anthony M. Heagerty
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Charlotte E. Bussey, Sarah B. Withers, Sophie N. Saxton, Neil Bodagh, Robert G. Aldous, Anthony M. Heagerty
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Editorial Material
Peripheral Vascular Disease
Sarah B. Withers, Sophie N. Saxton, Anthony M. Heagerty
Meeting Abstract
Peripheral Vascular Disease
Benedict Dare, Sophie Saxton, Lauren Toms, Charlotte Bussey, Anthony Heagerty
JOURNAL OF HYPERTENSION
(2018)
Article
Cardiac & Cardiovascular Systems
Sophie N. Saxton, Sarah B. Withers, Anthony M. Heagerty
CARDIOVASCULAR DRUGS AND THERAPY
(2019)
Article
Physiology
Sophie N. Saxton, Sarah B. Withers, Jakob Nyvad, Aleksandra Mazur, Vladimir Matchkov, Anthony M. Heagerty, Christian Aalkjaer
JOURNAL OF VASCULAR RESEARCH
(2019)
Review
Physiology
Sophie N. Saxton, Ben J. Clark, Sarah B. Withers, Etto C. Eringa, Anthony M. Heagerty
PHYSIOLOGICAL REVIEWS
(2019)
Article
Physiology
S. N. Saxton, A. M. Heagerty, S. B. Withers
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Sophie N. Saxton, Alice S. Whitley, Ryan J. Potter, Sarah B. Withers, Richard Grencis, Anthony M. Heagerty
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Sophie N. Saxton, Lauren K. Toms, Robert G. Aldous, Sarah B. Withers, Jacqueline Ohanian, Anthony M. Heagerty
Summary: PVAT plays a crucial role in regulating vascular tone through its anti-contractile effect, which can be compromised in obesity. Exercise has been shown to reverse PVAT dysfunction in obesity by reducing inflammation, increasing expression of beta(3)-adrenoceptors and OCT3, and restoring the vasodilator effects of adiponectin.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Sarah B. Withers, Toni Dewhurst, Chloe Hammond, Caroline H. Topham