期刊
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
卷 36, 期 10, 页码 2038-2047出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.116.306926
关键词
atherosclerosis; fatty liver; inflammation; macrophage; metabolic disease; veins
资金
- National Institutes of Health [R01HL66086, R01HL107550, R01HL126901]
- American Heart Association
- Japanese Heart Foundation/Bayer Japan
- Japan Society for the Promotion of Science
- Uehara Memorial Foundation
- Banyu Fellowship Program from the Banyu Life Science Foundation International
- American Heart Association Postdoctoral Fellowship
- International Research Fund for Subsidy of Kyushu University School of Medicine Alumni
The Notch signaling pathway regulates the development of various cell types and organs, and also contributes to disease mechanisms in adults. Accumulating evidence suggests its role in cardiovascular and metabolic diseases. Notch signaling components also control the phenotype of immune cells. Delta-like ligand 4 (Dll4) of the Notch pathway promotes proinflammatory activation of macrophages in vitro and in vivo. Dll4 blockade attenuates chronic atherosclerosis, vein graft disease, vascular calcification, insulin resistance, and fatty liver in mice. The Dll4-Notch axis may, thus, participate in the shared mechanisms for cardiometabolic disorders, serving as a potential therapeutic target for ameliorating these global health problems.
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