Article
Chemistry, Analytical
Hanchuang Zhu, Xue Zhang, Caiyun Liu, Yan Zhang, Meijun Su, Xiaodi Rong, Xin Wang, Mengyuan Liu, Xiaohui Zhang, Wenlong Sheng, Baocun Zhu
Summary: This study developed a fluorescent probe CB-NIR for the real-time reversible detection of volatile SO2 and FA, with many optical advantages.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Jinxiao Lyu, Chunfei Wang, Xuanjun Zhang
Summary: Sulfur dioxide and formaldehyde are important species that maintain redox homeostasis in life and are closely related to many physiological and pathological processes. A reversible ratiometric fluorescent probe has been synthesized to sensitively monitor these species, and it has been successfully applied in living cells and zebrafish.
Article
Chemistry, Physical
Lin Liu, Di Zhang, Man Li, Jiacheng Shi, Fengqi Guo, Jie Guo, Tieliang Wang
Summary: A new fluorescent probe ZZY was developed and synthesized to reversibly recognize sulfur dioxide (SO2) and formaldehyde (FA) in mitochondria. The probe exhibited high selectivity, sensitivity, low cytotoxicity, and a detection limit of 0.447 μM for SO2. It also showed good biocompatibility and successfully performed reversible imaging of SO2 and FA in mitochondria of living cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Analytical
Mengzhao Wang, Qinglong Liu, Xin Sun, Shuo Zheng, Yanyan Ma, Yun Wang, Mei Yan, Zhengliang Lu, Chunhua Fan, Weiying Lin
Summary: A novel NIR dual-emission fluorescent probe (BCou-BP) was developed for the detection of SO2 and FA with ratiometric detection ability and fast response time. The probe successfully visualized the dynamic change of endogenous mitochondrial SO2 and FA in living cells and mice. Endogenous FA could restore the fluorescence at 694 nm of BCou-BP due to the capture of SO2 from decomposition of the adduct BCou-BP-SO3H.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Wei Shu, Jin Yu, Huidan Wang, Anji Yu, Liyan Xiao, Zhuohang Li, Haitao Zhang, Yu Zhang, Yulong Wu
Summary: In this study, a reversible fluorescent probe GeP was designed for detecting intracellular glutathione. The probe exhibited fast response and high fluorescence change, and could target mitochondria. Additionally, GeP enabled superresolution fluorescence imaging of mitochondria.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Hui Sun, Qingyu Xu, Mingguang Ren, Fangong Kong
Summary: Formaldehyde (HCHO) is a common environmental toxicant that can harm the human respiratory tract and nervous system when exposed for a long period of time. HCHO is a carcinogen and increases the risk of cancer in humans. An innovative chitosan-based fluorescent probe (CS-FA) was developed for the detection of HCHO, which showed faster response time and high sensitivity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Shaohui Han, Hui Zhang, Jingpei Wang, Lei Yang, Minhuan Lan, Benhua Wang, Xiangzhi Song
Summary: By introducing an active triple bond into the molecular structure, sensors with good selectivity for distinguishing and detecting H2S and SO2 can be constructed. These sensors can not only detect the target substances in a dual-ratiometric manner, but also be successfully applied in living cells and zebrafish.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Linlin Wang, Linlu Zhao, Zhencai Xu, Yingying Ma, Xiaofeng Wang, Qi Sun, Heng Liu
Summary: The study reports a ratiometric NIR fluorescent probe Cou-Rh for monitoring bisulfite based on a Michael addition reaction, which demonstrates high sensitivity and selectivity in detecting bisulfite in living cells and zebrafish larvae.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Physical
Fei Luo, Yuhang Ji, Shiyi Zhang, Ziting Gao, Baoshun Jia, Zhixin Li, Jianbo Chang, Miao Lai, Xiaopeng Yang, Xiaoming Ji
Summary: In this study, a probe based on a triphenylamine fluorophore was developed for sensitive detection of HSO3- in plants and zebrafish. The probe showed a fast response time, high sensitivity, and excellent selectivity for HSO3-, and the changes in color and fluorescence could be easily observed. The probe was successfully applied for the detection of HSO3- in water samples and various biological systems.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Analytical
Xiao-Hong Li, Jin-Long Yan, Wei-Na Wu, Xiao-Lei Zhao, Yuan Wang, Yun-Chang Fan, Zhi-Hong Xu
Summary: A dual-response fluorescence probe was synthesized for detecting SO2 derivatives and viscosity, showing high selectivity and sensitive response to HSO3- with successful applications in living cells and water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Jianfei Liu, Jie Li, Jun Tang, Xiaopeng Yang, Di Zhang, Yong Ye, Yufen Zhao
Summary: Mercury and sulfur dioxide are common pollutants in the environment, affecting organisms and causing diseases. A bifunctional fluorescent probe LJ was designed to detect Hg2+ and SO2 simultaneously with high sensitivity. The study suggests that SO2 can be used as an antidote to mitigate the toxicity of Hg2+ in living cells.
Article
Chemistry, Analytical
Yueyin Liang, Yan Zhang, Mingxin Li, Zhiyuan Meng, Shuai Gong, Wenhao Du, Yiqin Yang, Zhonglong Wang, Shifa Wang
Summary: The novel camphor-based fluorescent probe CH has been synthesized for efficient and specific detection of formaldehyde, showing successful application in aqueous solution, gaseous form, real food and water samples, as well as effectively monitoring formaldehyde in living zebrafish through fluorescence imaging experiments.
MICROCHEMICAL JOURNAL
(2022)
Article
Spectroscopy
Yuting Du, Caixia Pan, Chunjuan Cao
Summary: In this research, a mitochondrial-target probe Mito-NPH was designed and synthesized, which exhibited specific response to HSO3-/ SO32- and could sense endogenous SO2 in mitochondria.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Yaru Sun, Yan Wang, Yaru Lu, Xiuqi Kong, Hua Wei, Qingxian Chen, Mei Yan, Baoli Dong
Summary: Sulfur dioxide (SO2) serves as a crucial signal molecule in living systems, and the mitochondria-targeted fluorescent probe Nap-L based on the FRET mechanism demonstrates high selectivity and efficiency in detecting and analyzing the dynamic balance of SO2 in living cells, showing significant potential for studying its biological roles.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Applied
Li Tian, Xiaofei Sun, Lulu Zhou, Keli Zhong, Shidi Li, Xiaomei Yan, Lijun Tang
Summary: A colorimetric and NIR fluorescent dual channels response probe for SO2/H2O2 in food safety and biology was developed in this study. The probe exhibited rapid and sensitive recognition of SO2, as well as detection ability for H2O2. The reversible response of the probe enables real-time imaging and sample analysis.
Article
Chemistry, Analytical
Yuping Zhao, Yanyan Ma, Weiying Lin
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Materials Science, Biomaterials
Yanyan Ma, Yuping Zhao, Rui Guo, Linlin Zhu, Weiying Lin
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Chemistry, Analytical
Yuping Zhao, Yanyan Ma, Weiying Lin
SENSORS AND ACTUATORS B-CHEMICAL
(2019)
Article
Chemistry, Analytical
Kangnan Wang, Shuyue Ma, Yanyan Ma, Yuping Zhao, Miaomiao Xing, Liyu Zhou, Duxia Cao, Weiying Lin
ANALYTICAL CHEMISTRY
(2020)
Review
Chemistry, Inorganic & Nuclear
Xuechen Li, Yuping Zhao, Junling Yin, Weiying Lin
COORDINATION CHEMISTRY REVIEWS
(2020)
Article
Biochemical Research Methods
Yonghe Tang, Yuping Zhao, Weiying Lin
Article
Chemistry, Analytical
Liu-Yi Liu, Yuping Zhao, Nan Zhang, Kang-Nan Wang, Minggang Tian, Qiling Pan, Weiying Lin
Summary: The unique probe QPP-AS, designed for ratiometric fluorescence response to nucleic acids, has advantages of selective nucleic acid response, ideal biocompatibility, and high signal-to-noise ratio. It has been successfully used for real-time tracking of nucleic acids in living cells and tissue sections, providing important information for clinicopathological diagnosis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Minggang Tian, Enxiang Ge, Baoli Dong, Yujing Zuo, Yuping Zhao, Weiying Lin
Summary: A novel fluorescent probe MT-LD was designed in this study to label lipid droplets and mitochondria, allowing for the visualization of their interaction during processes such as oleic acid treatment and starvation-induced autophagy. The probe revealed an increase in mitochondria-LD contact and peridroplet mitochondria amount in different tissues, such as brown adipose tissue and lung tissue. This work provides a valuable tool for investigating the interplay between mitochondria and lipid droplets, promoting research in fatty acid metabolism and autophagy.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Zihong Li, Jie Cheng, Ling Huang, Wenxiu Li, Yuping Zhao, Weiying Lin
Summary: Aging is a biological process that leads to increased morbidity and mortality. Studies on aging and anti-aging drugs are significant for human health. The new probe YDGAL for beta-galactosidase is highly sensitive and can visualize aging and evaluate the efficacy of anti-aging drugs.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yuping Zhao, Hyeong Seok Kim, Xiang Zou, Ling Huang, Xing Liang, Zihong Li, Jong Seung Kim, Weiying Lin
Summary: This study proposed a new strategy to investigate the interaction regulatory mechanisms between endoplasmic reticulum and autophagosomes by developing dual fluorescence lifetime probes localized to these two organelles. The research revealed that motile autophagosomes at the tips of endoplasmic reticulum drive the growth and sliding of ER tubules, ER reticulate tubules form a three-way junction centered on autophagosomes, and ER autophagy serves as a cell damage index during drug-induced apoptosis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Biomaterials
Xiang Zou, Yuping Zhao, Chaofeng Lai, Yun Liang, Weiying Lin
Summary: Chymotrypsin (CHT) is crucial for metabolism and cell processes, and abnormal levels can result in various diseases. The nonpeptide probe DT demonstrated high sensitivity and selectivity for detecting CHT, with potential applications in clinical diagnosis.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Yun Liang, Yuping Zhao, Chaofeng Lai, Xiang Zou, Weiying Lin
Summary: A novel mitochondrial viscosity-specific fluorescent probe Mito-VCI was designed based on fluorescent molecular rotors and FLIM strategies, showing sensitive detection of inflammatory signals and specific targeting in mitochondria of HeLa cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Ling Huang, Wanting Su, Yuping Zhao, Jingting Zhan, Weiying Lin
Summary: Mitochondria are the main sites for the production of hypochlorite (OCl-), with the protein adenine nucleotide translocase (ANT) playing a crucial role in ion and metabolite transportation. Mi-OCl-RP is a novel mitochondria-targeted ratiometric fluorescent probe with high selectivity and sensitivity, providing a robust molecular tool for investigating the biological functions of OCl- in living systems.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Yanyan Ma, Wenjie Gao, Linlin Zhu, Yuping Zhao, Weiying Lin
CHEMICAL COMMUNICATIONS
(2019)