Article
Chemistry, Applied
Beatriz Arauzo, M. Pilar Lobera, Antonio Monzon, Jesus Santamaria
Summary: Electrospray technique was utilized to produce inhalable ciprofloxacin-loaded chitosan sub-micron particles, which had small sizes and high surface charge for enhanced mucoadhesive properties and antimicrobial activity against common respiratory pathogens. The particles showed biocompatibility with alveolar cell line (A549) and promising results in antimicrobial efficacy.
CARBOHYDRATE POLYMERS
(2021)
Article
Instruments & Instrumentation
Linxia Jiang, Yijun Li, Jiaqi Yu, Jianhong Wang, Jiarui Ju, Jundong Dai
Summary: The new dry powder inhalable formulation of SAL developed in this study, with the addition of L-arginine and lecithin, showed improved biocompatibility and enhanced drug delivery to the lung, resulting in increased drug concentration and bioavailability. This formulation presents a promising strategy for the treatment of pulmonary fibrosis.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Varsha V. V. Nair, Hugh D. C. Smyth
Summary: This study explores the feasibility of engineering an inhaled powder formulation of the broad-spectrum antibiotic Tigecycline (TIG) for the treatment of respiratory tract infections. Micronized TIG showed excellent aerosolization efficiency and maintained stability in different inhaler devices. The results suggest that micronized TIG can be delivered via the pulmonary route for the treatment of lung infections.
MOLECULAR PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Ashish Sarode, Priyal Patel, Natalia Vargas-Montoya, Ayed Allawzi, Alisa Zhilin-Roth, Saswata Karmakar, Lianne Boeglin, Hongfeng Deng, Shrirang Karve, Frank DeRosa
Summary: Pulmonary delivery of mRNA via inhalation is a promising approach for RNA-based therapy for lung diseases. In this study, a successful mRNA-lipid nanoparticle (LNP) dry powder product (DPP) was developed. Formulation optimization of mRNA LNPs in DPP form resulted in efficient and functional delivery of mRNA for treatment of lung diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ho Wan Chan, Hok Wai Lee, Stephanie Chow, David Chi Leung Lam, Shing Fung Chow
Summary: This study developed a continuous process for fabricating inhalable nanoagglomerate dry powder formulations of remdesivir (RDV). The optimized formulation showed good redispersibility and aerosol performance, and the RDV nanoparticles displayed enhanced cell uptake and low cytotoxicity in vitro. Moreover, the continuous manufacturing process showed no significant differences in the quality attributes compared to the standalone batch mode.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Sara Stoilova, Walter Fiore, Valentina Trotta, Michela Mori
Summary: Hyaluronic acid is an important component of the respiratory mucosa, providing hydration and a protective barrier. Respiratory diseases degrade HA, reducing its barrier effect. PolmonYDE-FENCE/DYFESATM is a novel HA-based formulation delivered to the airways using a dry powder inhaler. In vitro and animal studies show that it forms a protective barrier on the upper airways without adverse effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Tushar Saha, Shubhra Sinha, Rhodri Harfoot, Miguel E. Quinones-Mateu, Shyamal C. Das
Summary: This study developed an inhalable dry powder formulation of ivermectin through spray-drying conditions, which could ensure sufficient drug concentrations in the respiratory tract. The ivermectin dry powder showed similar potency to inhibit SARS-CoV-2 replication compared to the solution form.
Article
Pharmacology & Pharmacy
Shalaleh Zendehdel Baher, Shadi Yaqoubi, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: This study aimed to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation for the local treatment of pulmonary arterial hypertension (PAH). The results confirmed that the spray drying technique can be used to obtain inhalable simvastatin nanoparticles with suitable inhalation performance.
Article
Chemistry, Multidisciplinary
Rick Heida, Renate Akkerman, Paulo H. Jacob Silva, Anke J. Lakerveld, Daniel Ortiz, Chiara Bigogno, Matteo Gasbarri, Puck B. van Kasteren, Francesco Stellacci, Henderik W. Frijlink, Anke L. W. Huckriede, Wouter L. J. Hinrichs
Summary: Respiratory viruses, including RSV, pose a significant global health burden. Entry inhibitors, such as CD-MUS, have shown promise as antiviral drugs that can prevent infection in the respiratory tract. In this study, CD-MUS was shown to be well tolerated when administered to mice's respiratory tract and retained its activity against RSV after spray drying. This research sets the foundation for future in vivo studies on the efficacy of CD-MUS in animal models of RSV infection.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Azin Jahangiri, Ali Nokhodchi, Kofi Asare-Addo, Erfan Salehzadeh, Shahram Emami, Shadi Yaqoubi, Hamed Hamishehkar
Summary: The study aimed to develop carrier-free inhalable CLX microparticles for dry powder inhalation (DPI) using electrospraying. The results showed that electrosprayed particles prepared from the ethanol-acetone solvent mixture at a drug concentration of 3% exhibited the best in vitro aerosolization properties.
Article
Pharmacology & Pharmacy
Sagar Dhoble, Vinod Ghodake, Vaibhavi Peshattiwar, Vandana Patravale
Summary: Pulmonary Hypertension (PH) is a condition with high mortality rate and non-reversible pathogenesis, currently managed with symptomatic relief medications. Research shows that anti-angiogenic Erlotinib liposomal formulation in inhalable dry powder form has the potential to improve physiological parameters and reverse pathological mechanisms in PH patients.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Malihe Karimi, Hossein Kamali, Marzieh Mohammadi, Mohsen Tafaghodi
Summary: Therapeutic proteins and peptides have gained attention for chronic diseases, and pulmonary drug administration is a promising alternative with acceptable bioavailability and stability. Stabilizing proteins through drying techniques is critical, and various methods have been used to prepare inhalable powders.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bhavya Vishwa, Afrasim Moin, D. V. Gowda, Syed M. D. Rizvi, Wael A. H. Hegazy, Amr S. Abu Lila, El-Sayed Khafagy, Ahmed N. Allam
Summary: The study aimed to achieve localized lung delivery of the anti-tubercular drug moxifloxacin targeting alveolar macrophages through inhalable microspheres as a dry powder inhaler method. The optimized microspheres showed preferential accumulation in lung tissue and sustained drug residence in the lung, suggesting a promising therapeutic approach for effective tuberculosis eradication and improved patient adherence to treatment.
Article
Pharmacology & Pharmacy
Salome S. Celi, Raquel Fernandez-Garcia, Andreina I. Afonso-Urich, M. Paloma Ballesteros, Anne Marie Healy, Dolores R. Serrano
Summary: In recent decades, the increasing incidence and prevalence of pulmonary fungal infections has become a global health problem due to the lack of specific antifungal therapies for pulmonary administration. This study developed microparticles and dry powder inhalers to improve the pharmacological effect of antifungal drugs, providing new options for pulmonary treatment.
Article
Pharmacology & Pharmacy
Khaled AboulFotouh, Haiyue Xu, Chaeho Moon, Robert O. Williams, Zhengrong Cui
Summary: The study demonstrated that thin-film freeze-drying technology can produce AS01(B) liposomal adjuvant and vaccines in freezing-insensitive, inhalable dry powder form without compromising particle size and immunogenicity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Infectious Diseases
Sue C. Nang, Yu-Wei Lin, Aleksandra Petrovic Fabijan, Rachel Y. K. Chang, Gauri G. Rao, Jonathan Iredell, Hak-Kim Chan, Jian Li
Summary: This review examines the current literature on phage pharmacology and highlights major pharmacological challenges for phage therapy. The lack of PK/PD information represents a major challenge for phage therapy, as therapeutic phages are biological entities with complex PK/PD.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
Yuncheng Wang, Dipesh Khanal, Adit B. Alreja, Hang Yang, Rachel Y. K. Chang, Waiting Tai, Mengyu Li, Daniel C. Nelson, Warwick J. Britton, Hak-Kim Chan
Summary: This study investigated the feasibility of producing inhalable powders of endolysins Cpl-1 and ClyJ-3 using spray drying method with excipients. The results showed that ClyJ-3 lost its bioactivity before the drying process, while Cpl-1 maintained its bioactivity in the spray-dried powders. Cpl-1 formulations with leucine and either lactose or trehalose exhibited promising physico-chemical properties and aerosol performances. These findings suggest that endolysin Cpl-1 can be formulated as spray dry powders for potential treatment of pulmonary infections.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Dipesh Khanal, Jinhee Kim, Jing Zhang, Wei-Ren Ke, Mark M. Banaszak Holl, Hak Kim Chan
Summary: The aim of this research was to use optical photothermal infrared spectroscopy (OPTIR) to analyse the chemical composition of pharmaceutical dry powder inhalation (DPI) aerosol particles. The study confirmed the presence of specific chemical peaks related to the drugs and excipients in the size-segregated particles of DPI formulations. It also found that the drug to excipient distribution ratio varied in different formulations, indicating heterogeneity. The results showed that OPTIR can serve as a valuable analytical platform for screening the physicochemical properties of DPI aerosols in solid state.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Athiya Azeem, Gajendra Singh, Lunjian Li, Hak-Kim Chan, Runyu Yang, Shaokoon Cheng, Agisilaos Kourmatzis
Summary: This study quantified the probability of agglomerate-to-wall collision using a unique image processing technique. The purpose was to investigate the effects of flow rate and particle size on the percentage of colliding agglomerates within a powder dispersion device.
PHARMACEUTICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Grace Tsz Yan Yau, Waiting Tai, Jonathon Carl Arnold, Hak-Kim Chan, Philip Chi Lip Kwok
Summary: The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. This review examines the preclinical and clinical evidence on the therapeutic use of CBD in treating various brain disorders, as well as different drug delivery approaches for CBD.
PHARMACEUTICAL RESEARCH
(2023)
Article
Oncology
Hiu Ting Chan, Satoshi Nagayama, Masumi Otaki, Yoon Ming Chin, Yosuke Fukunaga, Masashi Ueno, Yusuke Nakamura, Siew-Kee Low
Summary: This study compared the clinical utility and sensitivity of two different approaches to ctDNA analyses in colorectal cancer patients. It found that tumor-informed ctDNA analysis was more accurate in monitoring genetic mutations compared to tumor-agnostic analysis. Serial monitoring of ctDNA allowed for the early detection of disease recurrence, with a median of 5 months earlier than radiological imaging.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qixuan Zhu, Dazhao Gou, Hak-Kim Chan, Agisilaos Kourmatzis, Runyu Yang
Summary: This study conducted a numerical investigation using coupled computational fluid dynamics (CFD) and discrete element method (DEM) to evaluate the impact of design changes in a commercial dry powder inhaler (DPI) device on the aerosolization of an API-only formulation. Six different designs were proposed by modifying the mouthpiece and chamber of the original geometry. The performances of these designs were evaluated in terms of powder deposition and fine powder fraction (FPF) in the device. The study found that the resistance and FPF emitted varied with different designs, highlighting the importance of the mouthpiece and chamber design on powder dispersion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Christina Limantoro, Theerthankar Das, Meng He, Dmitry Dirin, Jim Manos, Maksym V. Kovalenko, Wojciech Chrzanowski
Summary: Antibiotic resistance is a global public health problem that requires the development of new alternative treatments. Metallic nanoparticles, with their unique properties and mechanisms, are an attractive option. This study tested the effects of gallium nanoparticles on clinical strains of Pseudomonas aeruginosa and multi-drug-resistant Acinetobacter baumannii, and found that they had an effect on biofilm formation.
Article
Computer Science, Interdisciplinary Applications
Zhiwei Shen, Jingliang Dong, Liam Milton-McGurk, Xinyu Cai, Hanieh Gholizadeh, Hak-Kim Chan, Ann Lee, Agisilaos Kourmatzis, Shaokoon Cheng
Summary: Understanding the effects of anatomical structures on nasal flow and particle deposition is important for drug delivery optimization and assessing the impact of pollutants and toxins inhalation. This study found that simplifying the geometry of the nasal cavity had minimal effect on airflow but influenced the location and quantity of particle deposition.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Qixuan Zhu, Maziar Kakhi, Chandana Jayasundara, Ross Walenga, Srinivas Ravindra Babu Behara, Hak-Kim Chan, Runyu Yang
Summary: This study develops a numerical model to investigate the effect of aperture size on powder dispersion in dry powder inhalers. The results show that larger apertures can reduce the emptying time of the capsule and increase the particle evacuation velocity. However, the impact energy of collisions is not significantly affected by aperture size. It is also found that inside the capsule, particle-particle collisions are more frequent, while outside the capsule, particle-wall collisions are more frequent.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yue Cao, Dipesh Khanal, Jinhee Kim, Rachel Yoon Kyung Chang, Alex Seungyeon Byun, Sandra Morales, Mark M. Banaszak Holl, Hak-Kim Chan
Summary: This study investigates the effect of common organic solvents on the stability of bacteriophages. The results show that the bacteriophages are more stable in alcohols and DMSO, and myoviruses tend to be more stable than podoviruses. The choice of solvents for phage formulation depends on the specific phage and solvent types.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Cell Biology
Rohan Flint, Daniel R. Laucirica, Hak-Kim Chan, Barbara J. Chang, Stephen M. Stick, Anthony Kicic
Summary: Pulmonary bacterial infections pose a significant health risk to individuals with chronic respiratory diseases, and the emergence of antimicrobial resistance has necessitated the development of alternative therapies. Phage therapy, which targets antimicrobial-resistant pathogens, shows promise as an adjunct or alternative to antibiotics. Delivery of phages to the lungs is crucial for respiratory infections, and nebulization has been identified as a potential method. However, the factors that affect phage stability during nebulized delivery have not been fully characterized.
Article
Chemistry, Multidisciplinary
Paris Jeffcoat, Shiva Kamini Divakarla, Elizabeth J. New, Wojciech Chrzanowski
Summary: This study investigates the nature and biological interactions of titanium dioxide nanoparticles commonly found in consumer products and food chains. The results show that these nanoparticles can induce autophagy in cells and dysregulate cellular homeostasis, particularly with regards to zinc levels. The study also highlights contradictions in cytotoxicity methodologies and emphasizes the importance of further understanding the mechanism of nanoparticle toxicity for informing regulatory approaches.
ENVIRONMENTAL SCIENCE-NANO
(2023)