Article
Chemistry, Analytical
Sergi Brosel-Oliu, Sandra Chacon-Aparicio, Josune Jimenez Ezenarro, Natalia Abramova, Naroa Uria, Andrey Bratov
Summary: This study reports a novel impedimetric biosensor based on a three-dimensional interdigitated electrode array (3D-IDEA) for detecting excessive growth of cyanobacteria in freshwater. The biosensor showed a linear response to cyanobacteria concentrations in the range of 10(2)-10(5) cells center dot mL(-1), and a filtration methodology was developed to recover cyanobacterial cells. The developed system can be used as an alarm system for selecting samples for laboratory analysis.
Article
Engineering, Chemical
R. N. Dalila, M. K. Md Arshad, Subash C. B. Gopinath, Conlathan Ibau, M. M. N. Nuzaihan, M. F. M. Fathil, U. Z. Mohd Azmi, Periasamy Anbu
Summary: A label-free Faradaic electrochemical impedimetric was developed for highly sensitive detection of C-reactive protein (CRP) using a gold interdigitated microelectrode biosensing platform enhanced by a gold nanoparticle-decorated molybdenum disulfide (Au-NPs/MoS2) nanosheet. The developed immunoassay showed a linear detection range of CRP and demonstrated excellent performance.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Chemistry, Analytical
S. Taniselass, Mohd Khairuddin Md Arshad, Subash C. B. Gopinath, M. F. M. Fathil, C. Ibau, Periasamy Anbu
Summary: The study demonstrates a label-free chemical bonding strategy using reduced graphene oxide basal plane functional groups for cardiac Troponin I detection, showing high sensitivity and analytical performance, suitable for biosensor applications.
Article
Chemistry, Analytical
Taekeon Jung, Young-Ran Yun, Jaehyun Bae, Sung Yang
Summary: By integrating magnetic particle conjugation for bacteria concentration and separation, a new impedimetric bacteria-detection sensor has been developed for rapid and accurate detection of low bacteria concentrations in food samples.
ANALYTICA CHIMICA ACTA
(2021)
Review
Chemistry, Physical
Veronika Pinkova Gajdosova, Lenka Lorencova, Anna Blsakova, Peter Kasak, Tomas Bertok, Jan Tkac
Summary: The review discusses the challenges and solutions for the successful design of impedimetric biosensors for highly sensitive affinity detection of proteins, including the effects of gold etching, ionic strength, interface properties, and analyte:bioreceptor ratio. Additionally, it touches on other factors like conductive interfaces, small bioreceptors, and strategies for improved selectivity and sensitivity.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Chemistry, Analytical
Ece Eksin, Hilal Torul, Ece Yarali, Ugur Tamer, Pagona Papakonstantinou, Arzum Erdem
Summary: In this study, a paper-based electrode assemble was developed for detecting miRNA 155 via electrochemical impedance spectroscopy. The system utilized gold nanoparticles modified electrodes and showed different detection limits in different media, while also demonstrating selectivity against non-complementary and mismatch miRNA sequences under various conditions. The impedimetric biosensor's analytical performance and selectivity were also evaluated in fetal bovine serum.
Article
Chemistry, Multidisciplinary
Haruka Honda, Yusuke Kusaka, Haiyun Wu, Hideaki Endo, Daiju Tsuya, Hitoshi Ohnuki
Summary: We propose a rational electrode design concept for affinity biosensors based on electrochemical impedance spectroscopy to suppress device-to-device variations. A novel micro-gap parallel plate electrode (PPE) was developed to achieve uniform current distribution and maximize sensing contribution. Compared to the traditional micro-structured interdigitated electrode, this design shows smaller device-to-device variations and allows for ultrasensitive detection.
Article
Chemistry, Analytical
Jia Yang, Danting He, Na Zhang, Chengguo Hu
Summary: A simple filtration method for the scalable fabrication of disposable single-walled carbon nanotubes (SWCNTs)-based antifouling electrochemical sensors is reported. The resulting SWCNTs sensor exhibits a sensitive response towards morphine and allows the direct detection in unprocessed complex foods.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Ian Gonzalez-Afanador, Hongyang Shi, Christopher Holbrook, Xiaobo Tan, Nelson Sepulveda
Summary: Monitoring invasive sea lamprey populations in the Laurentian Great Lakes is crucial for protecting the region's fishing industry and biodiversity. Remote lamprey detection systems are desirable for their continuous monitoring capabilities, but a lack of effective detection methods hinders their development. A new sensor composed of interdigitated electrodes and a DC measurement system is proposed for accurately detecting lamprey attachment underwater.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Ivana Podunavac, Teodora Knezic, Mila Djisalov, Nejra Omerovic, Marko Radovic, Ljiljana Janjusevic, Dimitrije Stefanovic, Marko Panic, Ivana Gadjanski, Vasa Radonic
Summary: In recent years, advancements in microfluidic and sensor technologies have led to the development of new methods for monitoring cell growth in both macro- and micro-systems. This paper proposes a microfluidic platform with an integrated impedimetric sensor for cell growth monitoring in a scaled-down simulator. The proposed method, integrated into a simple and rapid fabrication microfluidic system, offers an excellent candidate for scaled-down analyses of cell growth and can be useful in optimizing bioprocesses like cultivated meat production.
Article
Materials Science, Multidisciplinary
Jianqiang Guo, Jingjing Tan, Ning Dou, Thangavel Lakshmipriya, Subash C. B. Gopinath
Summary: Abdominal aortic aneurysm (AAA) is a bulge in the abdominal aorta with potentially fatal consequences. Detection of MMP-9 levels can help identify the condition of AAA, and this research focused on enhancing MMP-9 detection on an IDE sensing system.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Chemistry, Analytical
Tal Stern Bauer, Ravit Yakobi, Mattan Hurevich, Shlomo Yitzchaik, Zvi Hayouka
Summary: The biosensing of bacterial pathogens is a top priority, and electrochemical biosensors offer a promising solution for rapid detection. In this study, random peptide mixtures (RPMs) composed of phenylalanine and lysine were examined as a potential recognition layer for sensing. RPMs were found to attract various bacteria and could be measured using electrochemical impedance spectroscopy. Pseudomonas aeruginosa showed the highest increase in charge-transfer resistance (R-CT), indicating its potential as a target for bacterial biosensors.
Article
Nanoscience & Nanotechnology
Lian C. T. Shoute, Gaser N. Abdelrasoul, Yuhao Ma, Pedro A. Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L. Charlton, Jamil N. Kanji, Shawn Babiuk, Jie Chen
Summary: The COVID-19 pandemic presents challenges for existing diagnostic tools, so there is a need to develop portable devices for fast and accurate detection. An impedimetric immunosensor based on microelectrode array has been developed to detect SARS-CoV-2 antibodies. The sensor uses non-Faradaic impedance and has a sensitivity that can be enhanced by adjusting the ionic strength. It has an LOD of 0.4 BAU/ml and can detect anti-spike antibodies in COVID-19 patient sera within 1 hour.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Biophysics
Xin Li, Jingying Pan, Yue Wu, Huan Xing, Zijian An, Zhenghan Shi, Jingjiang Lv, Fenni Zhang, Jing Jiang, Di Wang, Ray P. S. Han, Bin Su, Yanli Lu, Qingjun Liu
Summary: A wireless facemask based on Ti3C2Tx MXene is developed for the noninvasive monitoring of breath acetone (BrAC) and real-time tracking of lipid metabolism. The facemask can not only detect acetone but also filter out breath interference. It is integrated with a miniaturized flexible detection tag for easy BrAC detection and wireless data transmission. The system enables detection of BrAC down to 0.31 ppm in breath.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Robert Daly, Tarun Narayan, Han Shao, Alan O'Riordan, Pierre Lovera
Summary: The study introduces a novel platinum-based microband electrode array for trace detection of copper, achieving a detection limit of 0.8 µg/L. By controlling the pH at the surface of the sensors, the detection limit for copper was lowered, allowing for detection of standard copper solutions down to 5 µg/L (ppb) without the need for reagents. This reagent-free method opens up possibilities for autonomous, in situ monitoring of pollutants in water bodies.
Article
Chemistry, Analytical
C. Ocana, M. Munoz-Correas, N. Abramova, A. Bratov
Article
Chemistry, Analytical
Cristina Ocana, Sergi Brosel-Oliu, Natalia Abramova, Andrey Bratov
Summary: The study presents a low-cost, simple, and rapid multichannel system for evaluating bacteria response to antibiotics by monitoring pH changes using silicon chips covered with Ta(2)O(5) thin layer pH sensors. The system successfully monitored Escherichia coli's response to various antibiotics in just 5 hours, demonstrating its potential for disposable use.
INSTRUMENTATION SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Sergi Brosel-Oliu, Sandra Chacon-Aparicio, Josune Jimenez Ezenarro, Natalia Abramova, Naroa Uria, Andrey Bratov
Summary: This study reports a novel impedimetric biosensor based on a three-dimensional interdigitated electrode array (3D-IDEA) for detecting excessive growth of cyanobacteria in freshwater. The biosensor showed a linear response to cyanobacteria concentrations in the range of 10(2)-10(5) cells center dot mL(-1), and a filtration methodology was developed to recover cyanobacterial cells. The developed system can be used as an alarm system for selecting samples for laboratory analysis.
Article
Chemistry, Multidisciplinary
Cecilia Wetzl, Sergi Brosel-Oliu, Marco Carini, Desire Di Silvio, Xavi Illa, Rosa Villa, Anton Guimera, Elisabet Prats-Alfonso, Maurizio Prato, Alejandro Criado
Summary: Solution-gated graphene field effect transistors (GFETs) have shown their versatility in electrophysiological recordings and sensing. This study presents a controlled covalent functionalisation strategy using molecular design and electrochemical triggering for monitoring of serotonin.
Article
Chemistry, Multidisciplinary
Cecilia Wetzl, Sergi Brosel-Oliu, Marco Carini, Desire Di Silvio, Xavi Illa, Rosa Villa, Anton Guimera, Elisabet Prats-Alfonso, Maurizio Prato, Alejandro Criado
Summary: This work presents a controlled covalent functionalization strategy using molecular design and electrochemical triggering for monitoring serotonin, enabling monolayer-like functionalization of GFET arrays.
Article
Biochemical Research Methods
S. Brosel-Oliu, O. Mergel, N. Uria, N. Abramova, P. van Rijn, A. Bratov
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)