Article
Hematology
Andrew M. Cobb, Syabira Yusoff, Robert Hayward, Sadia Ahmad, Mengxi Sun, Anja Verhulst, Patrick C. D'Haese, Catherine M. Shanahan
Summary: The study found that DNA damage stimulates Runx2 accumulation and enhances its activation of osteogenic target genes, leading to increased calcification. Runx2 also participates in DNA repair and its PARylation in response to genotoxic stress affects its localization at DNA lesions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Anda Huna, Audrey Griveau, David Vindrieux, Sara Jaber, Jean-Michel Flaman, Delphine Goehrig, Lamia Azzi, Jean-Jacques Medard, Sophia Djebali, Hector Hernandez-Vargas, Robert Dante, Lea Payen, Jacqueline Marvel, Philippe Bertolino, Sebastien Aubert, Pierre Dubus, David Bernard
Summary: The study reveals that PLA2R1 suppresses aging-induced tumors by repressing PARP1 expression and inducing DNA damage. Mechanistically, PLA2R1 represses PARP1 via a ROS-Rb signaling axis, leading to DNA damage and tumor suppressive responses in cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Stefano Squarzoni, Elisa Schena, Patrizia Sabatelli, Elisabetta Mattioli, Cristina Capanni, Vittoria Cenni, Maria Rosaria D'Apice, Davide Andrenacci, Giuseppe Sarli, Valeria Pellegrino, Anna Festa, Fabio Baruffaldi, Gianluca Storci, Massimiliano Bonafe, Catia Barboni, Mara Sanapo, Anna Zaghini, Giovanna Lattanzi
Summary: The study demonstrates that tocilizumab inhibits progeroid features in HGPS cells and progeroid mice, suggesting it as a valuable tool in HGPS therapy and potentially in treating various aging-related disorders.
Review
Nutrition & Dietetics
Jingqian Su, Qiaofen Su, Shan Hu, Xinglin Ruan, Songying Ouyang
Summary: Aging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Ginseng, a traditional Chinese medicine, has active components that have antioxidant, anti-apoptotic, neuroprotective, and age-delaying effects. This review focuses on the anti-aging mechanisms of the active ingredients of ginseng and expands the scope of ideas for further research on natural products and aging.
Article
Multidisciplinary Sciences
Cheryl L. Smith, Yemin Lan, Rajan Jain, Jonathan A. Epstein, Andrey Poleshko
Summary: The nuclear architecture of rod photoreceptor cells in nocturnal mammals differs from that of other animal cells, with euchromatin and heterochromatin occupying opposite positions. This unique structure is achieved through global relabeling of the rod cell epigenome, involving histone modifications such as H3K9 methylation. This study highlights the significance of epigenetic changes in shaping nuclear architecture in postmitotic cells.
Article
Cardiac & Cardiovascular Systems
Francesca Bartoli-Leonard, Fiona L. Wilkinson, Andrew Schiro, Ferdinand Serracino Inglott, M. Yvonne Alexander, Ria Weston
Summary: This study found that in diabetic calcified arteries, SIRT1 levels are reduced and DNA damage marker expression is increased. Vascular smooth muscle cells isolated from diabetic patients show elevated DNA damage and senescence. In vitro, hyperglycaemic conditions induced DNA damage and enhanced senescence in vascular smooth muscle cells.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Siyi Wang, Li Li, Qingchun Liang, Yuanzhi Ye, Zirong Lan, Qianqian Dong, An Chen, Mingwei Fu, Yining Li, Xiaoyu Liu, Jing-Song Ou, Lihe Lu, Jianyun Yan
Summary: This study demonstrates for the first time that smooth muscle cell-specific deletion of SIRT6 facilitates vascular calcification by suppressing DNA damage repair. Modulation of SIRT6 and DNA damage repair may represent a therapeutic strategy for vascular calcification.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Riva Shmulevich, Valery Krizhanovsky
Summary: Senescence is a crucial biological process that can block tumorigenesis and limit tissue damage, but accumulation of senescent cells can promote age-related diseases. Recent advances have shown the significant role of cellular metabolism in regulating cell senescence, and future research should focus on elucidating metabolic mechanisms to develop new therapeutic strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Chemistry, Multidisciplinary
Yizhuo Che, Xiaofei Yang, Peng Jia, Tingjie Wang, Dan Xu, Tianxue Guo, Kai Ye
Summary: This study introduces two global physical properties, DNA density and distance to nuclear periphery, and constructs a 2D matrix called D-2 plot for mapping genetic and epigenetic markers. Functional markers on the D-2 plot show distinct patterns, indicating its ability to compartmentalize functional genome regions. Furthermore, this study successfully identifies constantly active and newly activated genes during olfactory sensory neuron maturation based on the trajectories on the D-2 plot. The research reveals that the D-2 plot effectively categorizes functional regions and provides a universal and transcription-related measurement for the 3D genome.
Article
Cell Biology
Agathe Marcelot, Felipe Rodriguez-Tirado, Philippe Cuniasse, Mei-ling Joiner, Simona Miron, Alexey A. Soshnev, Mimi Fang, Miles A. Pufall, Katherine D. Mathews, Steven A. Moore, Sophie Zinn-Justin, Pamela K. Geyer
Summary: Barrier-to-autointegration factor (BAF) is an essential component of the nuclear lamina that regulates gene expression, cell cycle progression, and nuclear integrity. A dominant pathogenic BAF variant, Gly16Arg, has been identified in a patient with progressive neuromuscular weakness, causing changes in chromatin structure and nuclear functions. This study demonstrates how a missense mutation can alter protein conformation and lead to a dominant disease phenotype.
Article
Plant Sciences
Nan Wang, Ezgi Suheyla Karaaslan, Natalie Faiss, Kenneth Wayne Berendzen, Chang Liu
Summary: Plant nuclear lamin proteins play conserved roles in modulating stress responses, with CRWN and NMCP in Arabidopsis being key proteins for maintaining nuclear integrity and responding to external stresses.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Cell Biology
Rui Jin, Chang Niu, Fengyun Wu, Sixin Zhou, Tao Han, Zhe Zhang, Entao Li, Xiaona Zhang, Shanrong Xu, Jiadong Wang, Shen Tian, Wei Chen, Qinong Ye, Cheng Cao, Long Cheng
Summary: DNA damage, a hallmark of aging, promotes SARS-CoV-2 infection, while inhibition of DNA damage response hampers viral entry. This study reveals the important role of DNA damage in SARS-CoV-2 infection and suggests that promoting DNA repair can alleviate viral infection and disease severity.
Editorial Material
Cell Biology
Irene Franco, Gwladys Revechon, Maria Eriksson
Summary: The causal effects of somatic mutations in the aging process are still not clear due to technological and methodological weaknesses. Studying somatic mutagenesis in different experimental systems can help understand its functional role.
Review
Biochemistry & Molecular Biology
Alexandra G. Liddane, James M. Holaska
Summary: It is commonly recognized in the field that cancer cells exhibit changes in the size and shape of their nuclei, which can impact cell migration and metastasis. Nuclear structural changes are predicted to regulate cancer cell migration across various tumor types, and alterations in nuclear lamina proteins, such as emerin, may play a significant role in cancer progression and clinical outcomes. Understanding the factors driving these nuclear abnormalities and their functional consequences remains an area of ongoing research in the field of cancer biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Suhao Han, Austin Sims, Anthony Aceto, Brigitte E. F. Schmidt, Marcel P. P. Bruchez, Aditi U. U. Gurkar
Summary: Oxidative DNA damage increases with age in all tissues, but to varying degrees. Researchers have developed a chemoptogenetic tool in Caenorhabditis elegans that can induce oxidative DNA damage and assess its effects on aging. By targeting a specific histone, they were able to induce DNA damage, leading to embryonic lethality, developmental delay, and reduced lifespan. This tool will allow researchers to study the role of DNA damage in aging at an organismal level.
Review
Biochemistry & Molecular Biology
Can Zhou, Li Rao, Catherine M. Shanahan, Qiuping Zhang
BIOCHEMICAL SOCIETY TRANSACTIONS
(2018)
Review
Cardiac & Cardiovascular Systems
Andrew L. Durham, Mei Y. Speer, Marta Scatena, Cecilia M. Giachelli, Catherine M. Shanahan
CARDIOVASCULAR RESEARCH
(2018)
Editorial Material
Cell Biology
Daniel Brayson, Chin Yee Ho, Catherine M. Shanahan
JOURNAL OF CELL BIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Yana Dautova, Alexander N. Kapustin, Kevin Pappert, Matthias Epple, Hanneke Okkenhaug, Simon J. Cook, Catherine M. Shanahan, Martin D. Bootman, Diane Proudfoot
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Editorial Material
Urology & Nephrology
Adriana Dusso, Maria Isabel Colombo, Catherine M. Shanahan
KIDNEY INTERNATIONAL
(2018)
Article
Multidisciplinary Sciences
Anique D. ter Braake, Paul T. Tinneman, Catherine M. Shanahan, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
SCIENTIFIC REPORTS
(2018)
Article
Cardiac & Cardiovascular Systems
Gonca Suna, Wojciech Wojakowski, Marc Lynch, Javier Barallobre-Barreiro, Xiaoke Yin, Ursula Mayr, Ferheen Baig, Ruifang Lu, Marika Fava, Robert Hayward, Chris Molenaar, Stephen J. White, Tomasz Roleder, Krzysztof P. Milewski, Pawel Gasior, Piotr P. Buszman, Pawel Buszman, Marjan Jahangiri, Catherine M. Shanahan, Jonathan Hill, Manuel Mayr
Article
Hematology
Malgorzata Furmanik, Rick van Gorp, Meredith Whitehead, Sadia Ahmad, Jayanta Bordoloi, Alexander Kapustin, Leon J. Schurgers, Catherine M. Shanahan
Summary: This study reveals that ER stress induces vascular calcification by increasing release of Grp78-loaded EVs, and for the first time links warfarin to promoting calcification by increasing EV release. The results of the study provide a novel mechanism of action for warfarin and the role of ER stress in cargo loading of EVs.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Andrew M. Cobb, Syabira Yusoff, Robert Hayward, Sadia Ahmad, Mengxi Sun, Anja Verhulst, Patrick C. D'Haese, Catherine M. Shanahan
Summary: The study found that DNA damage stimulates Runx2 accumulation and enhances its activation of osteogenic target genes, leading to increased calcification. Runx2 also participates in DNA repair and its PARylation in response to genotoxic stress affects its localization at DNA lesions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Meredith Whitehead, Catherine M. Shanahan
CARDIOVASCULAR RESEARCH
(2021)
Review
Engineering, Biomedical
Suzette T. Lust, Catherine M. Shanahan, Rebecca J. Shipley, Pablo Lamata, Eileen Gentleman
Summary: Cardiovascular diseases are often the result of pathological remodelling of blood vessels, driven by changes in vascular cell behaviors and abnormalities in ECM proteins. In vitro models of blood vessels can be useful for studying disease progression, with a focus on maintaining normal cell phenotypes, mimicking cell-ECM interactions, and promoting intercellular communication. By combining advancements in materials science, cell biology, fluidics, and modeling, it may be possible to create patient-specific blood vessel models for developing and testing therapies.
ACTA BIOMATERIALIA
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Marina Cecelja, Catherine M. Shanahan
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Pantelis Sarafidis, Sven Martens, Athanasios Saratzis, Daniella Kadian-Dodov, Patrick T. Murray, Catherine M. Shanahan, Allen D. Hamdan, Daniel T. Engelman, Ulf Teichgraber, Charles A. Herzog, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Holger Reinecke, Kirsten Johansen
Summary: Chronic kidney disease is an independent risk factor for abdominal aortic aneurysm, cardiovascular events, and all-cause mortality after AAA or thoracic aortic dissection surgery. Acute kidney injury (AKI) after aortic surgery occurs at a high rate and is linked to future cardiovascular events and mortality. The development of AKI and long-term kidney function differ based on the type of AAA intervention. Knowledge about AAA in the general population may not be applicable to CKD patients, who have higher co-morbidity prevalence and perioperative complication risks. This review summarizes the epidemiology, pathophysiology, diagnosis, and treatment of Aortic Diseases in CKD, highlighting knowledge gaps and areas of controversy for future research.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Pamela Swiatlowska, Brian Sit, Zhen Feng, Emilie Marhuenda, Ioannis Xanthis, Simona Zingaro, Matthew Ward, Xinmiao Zhou, Qingzhong Xiao, Cathy Shanahan, Gareth E. Jones, Cheng-han Yu, Thomas Iskratsch
Summary: The study shows that vascular smooth muscle cells (VSMCs) undergo a phenotypic switch when exposed to a combination of hypertensive pressure and matrix compliance, which are prevalent during atherosclerosis. The molecular mechanism involves the regulation of the actin cytoskeleton through cofilin via distinct pathways.
Review
Hematology
Nadia R. Sutton, Rajeev Malhotra, Cynthia St. Hilaire, Elena Aikawa, Roger S. Blumenthal, Grace Gackenbach, Parag Goyal, Adam Johnson, Sagar U. Nigwekar, Catherine M. Shanahan, Dwight A. Towler, Brooke N. Wolford, Yabing Chen
Summary: Cardiovascular disease is the leading cause of death globally, particularly in individuals over the age of 65, with myocardial infarction and stroke being the primary contributors. The development of vascular aging and vascular calcification with aging is not fully understood, but is believed to be influenced by genetic risk, environmental factors, and the ability of vascular smooth muscle cells to acquire an osteogenic phenotype. Understanding the molecular mechanisms behind age-associated vascular pathology may lead to strategies for promoting healthy vascular aging. This article provides a summary of current knowledge on age-associated vascular disease, with a focus on vascular calcification.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
