Article
Obstetrics & Gynecology
Wenqian Yu, Baowei Shao, Meng Li, Pengfei Zhang, Haijie Li, Xilong Teng, Honglu Wang, Guohai Su, Fengquan Zhang, Na Li
Summary: The study found a positive association between metabolic syndrome and coronary artery calcification prevalence, especially in female participants. In postmenopausal women, metabolic syndrome was associated with a higher prevalence of coronary artery disease compared to premenopausal women and men.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Geriatrics & Gerontology
Hecheng Yu, Zhiqiang Tao, Xiaoming Luo, Ben Huang, Longdian Zhou
Summary: This study investigated the association between calcium intake and MET with vertebral fractures, and explored the role of MET in the relationship between calcium intake and vertebral fractures. The results showed that the combination of MET < 160 and calcium intake ≥670 mg was associated with decreased risks of vertebral fractures.
Article
Urology & Nephrology
Miyeun Han, Hyunsuk Kim, Hyo Jin Kim, Eunjeong Kang, Yong-Soo Kim, Kyu Hun Choi, Soo Wan Kim, Curie Ahn, Kook-Hwan Oh
Summary: The study found that uric acid level was significantly associated with coronary artery calcification in early chronic kidney disease but not in advanced chronic kidney disease.
Article
Medicine, General & Internal
Yoshiki Hata, Junji Mochizuki, Shuichi Okamoto, Hiroaki Matsumi, Katsushi Hashimoto
Summary: This study aimed to investigate the association between aortic calcification and coronary artery calcification, and to explore the feasibility of using chest radiography to evaluate the risk of future cardiovascular events. The results showed that aortic calcification was associated with coronary artery calcification, and calcification in the aortic arch may be related to coronary artery calcification.
Article
Pharmacology & Pharmacy
A. Zlibut, R. Orzan, D. Farah, C. Cionca, I. D. Muresan, D. Horvat, I. D. Popa, R. Revnic, M. Florea, T. Mocan, L. Agoston-Colder
Summary: The combination of CCS, EFV, and NoPs increases the predictive ability for obstructive CAD of each parameter used alone, which could be useful for developing a novel scoring system.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Subhabrata Moitra, Ali Farshchi Tabrizi, Fadi Khadour, Linda Henderson, Lyle Melenka, Paige Lacy
Summary: In this cross-sectional study, we found that exposure to insulating materials, especially asbestos, increases the risk of coronary artery disease among workers. This study is important for the protection of workers from the adverse effects of these materials.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Transplantation
Ida M. H. Sorensen, Sasha S. Bjergfelt, Henrik O. Hjortkjaer, Klaus F. Kofoed, Theis Lange, Bo Feldt-Rasmussen, Christina Christoffersen, Susanne Bro
Summary: This study found that calcium scores in the coronary, carotid, and thoracic arteries are independent predictors of major adverse cardiovascular events and all-cause mortality in patients with chronic kidney disease. The potential of calcification in these three arterial sites for predicting cardiovascular events and mortality was most pronounced.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Zhijian Wu, Weichang Yang, Meng Li, Fengyuan Li, Ren Gong, Yanqing Wu
Summary: The study found a negative association between dietary decanoic acid (DDA) and the prevalence of coronary artery disease (CAD). This relationship was significant among males and non-Hispanic white individuals, and both sex and race may modify this relationship.
Article
Endocrinology & Metabolism
Karen Gronemeyer, Carmina Teresa Fuss, Franca Hermes, Armin Plass, Ann-Cathrin Koschker, Anke Hannemann, Henry Voelzke, Stefanie Hahner
Summary: Patients with chronic hypoparathyroidism have a higher prevalence of impaired renal function, which is independent of renal calcifications. Disease duration and serum phosphate or 24-hour urinary calcium excretion are predictors for renal calcifications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Meng-Ting Tsou, Jau-Yuan Chen
Summary: The association of non-alcoholic fatty liver disease (NAFLD) and abdominal obesity (AO) with subclinical atherosclerosis varies by gender. In men, NAFLD is more closely associated with coronary artery calcification (CAC) and coronary artery disease (CAD) risk, while in women, abdominal obesity shows a stronger association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Hae-Ryong Yun, Young Su Joo, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Nak-Hoon Son, Tae-Hyun Yoo, Shin-Wook Kang, Suah Sung, Kyu-Beck Lee, Joongyub Lee, Kook-Hwan Oh, Seung Hyeok Han
Summary: An elevated coronary artery calcification score (CACS) is associated with increased cardiovascular disease risk in patients with CKD. The study found that higher CACS is also associated with a significantly increased risk of adverse kidney outcomes and CKD progression.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Emmanuel Cosson, Minh Tuan Nguyen, Imen Rezgani, Sopio Tatulashvili, Meriem Sal, Narimane Berkane, Lucie Allard, Pierre-Yves Brillet, Helene Bihan
Summary: This study evaluated the association between epicardial adipose tissue (EAT) volume and coronary artery calcification (CAC) in patients with diabetes, finding that EAT volume was independently associated with CAC >= 100 AU. Factors such as age, diabetes type, medication use, and other health conditions were also related to CAC levels. The findings suggest that reducing EAT volume through physical exercise, improved diet, and pharmaceutical interventions may improve future cardiovascular risk outcomes in this population.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Chemistry, Analytical
Tim Kambic, Nejc Sarabon, Vedran Hadzic, Mitja Lainscak
Summary: Self-reported physical activity levels in patients with coronary artery disease tend to overestimate moderate-to-vigorous-intensity physical activity and underestimate sedentary behavior, compared to objective measures. Objective assessment using accelerometers is recommended for more accurate evaluation.
Article
Psychiatry
Trine Trab, Rubina Attar, Svend Eggert Jensen, Simon Grontved, Jens Brondum Frokjaer, Christoffer Polcwiartek, Rene Ernst Nielsen
Summary: The study found that the amount of coronary artery calcium in patients with schizophrenia follows norm percentiles, and variables associated with the calcium score are similar in patients with schizophrenia and the general population. The findings suggest that the calcium score may not be sufficient to detect the risk of coronary heart disease in patients with schizophrenia. Future studies should explore other measures of subclinical coronary heart disease for early detection and intervention.
Article
Endocrinology & Metabolism
Fengyu Jia, Suxia Wang, Ying Jing, Hanhui Zhao, Peng Rong, Hongbin Zhang, Wenting Lu, Yan Xue, Gang Sun
Summary: The study found a significant elevation of osteocalcin (OC) in MHD patients, positively correlated with phosphorus, iPTH, FGF23, and negatively correlated with age. Age and OC were identified as risk factors for high AACs (>= 5).
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Adam J. Santanasto, Joseph M. Zmuda, Ryan K. Cvejkus, Christopher L. Gordon, Sangeeta Nair, J. Jeffrey Carr, James G. Terry, Victor W. Wheeler, Iva Miljkovic
Summary: This study examined the association between myosteatosis and physical function in African Caribbean men. The results showed that myosteatosis in the calf and thigh was strongly associated with grip strength and performance measures of physical function, while myosteatosis in the abdomen may have some utility when abdominal images are all that are available.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jingzhong Ding, Kurt Lohman, Anthony Molina, Osvaldo Delbono, Alain Bertoni, Steven Shea, Wendy Post, Xiuqing Guo, R. Graham Barr, Ani W. Manichaikul, James S. Pankow, Jerome Rotter, Ina Hoeschele, Stephen B. Kritchevsky, Yongmei Liu
Summary: Translating our knowledge of biological aging from animals to humans can lead to new approaches for targeting multiple aging-related diseases and increasing health span. This study used transcriptomic signatures of monocytes to identify aging pathways underlying multiple aging-related diseases in humans for the first time.
Article
Endocrinology & Metabolism
Brian T. Steffen, Weihong Tang, Pamela L. Lutsey, Ryan T. Demmer, Elizabeth Selvin, Kunihiro Matsushita, Alanna C. Morrison, Weihua Guan, Mary R. Rooney, Faye L. Norby, Nathan Pankratz, David Couper, James S. Pankow
Summary: Proteomics analysis identified plasma proteins associated with the risk of type 2 diabetes. These proteins may serve as potential targets for intervention or pharmacological approaches to prevent, reverse, or slow down the progression of type 2 diabetes.
Article
Geriatrics & Gerontology
Pablo Martinez-Amezcua, Emmanuel Garcia Morales, Kelley P. Gabriel, Erin E. Dooley, Bjoern Hornikel, Josef Coresh, Frank R. Lin, James S. Pankow, A. Richey Sharrett, Jennifer A. Schrack, Kevin J. Sullivan, Nicholas Reed, Jennifer A. Deal, Priya Palta
Summary: This study examines the association between midlife leisure-time physical activity and hearing loss in older ages. Results show that meeting physical activity recommendations during midlife is associated with better hearing and reduced risk of hearing loss in older ages.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemical Research Methods
Bruno Bohn, Pamela L. Lutsey, Weihong Tang, James S. Pankow, Faye L. Norby, Bing Yu, Christie M. Ballantyne, Eric A. Whitsel, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study compared the proteome of statin users and nonusers and found differences in proteins unrelated to lipid metabolism. Further investigation into these differences may help elucidate the pleiotropic effects of statins.
JOURNAL OF PROTEOMICS
(2023)
Article
Geriatrics & Gerontology
Corey W. Bown, Omair A. Khan, Dandan Liu, Samuel W. Remedios, Kimberly R. Pechman, James G. Terry, Sangeeta Nair, L. Taylor Davis, Bennett A. Landman, Katherine A. Gifford, Timothy J. Hohman, John Jeffrey Carr, Angela L. Jefferson
Summary: This study found that enlarged perivascular spaces (ePVS) are difficult to quantify and their etiologies and consequences are unclear. The results suggest that higher aortic stiffness is associated with greater basal ganglia ePVS burden, and ePVS burden is associated with adverse cognitive trajectory, highlighting the clinical relevance of ePVS.
NEUROBIOLOGY OF AGING
(2023)
Article
Cardiac & Cardiovascular Systems
Venkat S. Manubolu, Song Mao, April Kinninger, Suraj Dahal, Khadije Ahmad, Ruby Havistin, Yanlin Gao, Chris Dailing, J. Jeffrey Carr, Sion K. Roy, Matthew J. Budoff
Summary: This study examined the relationship between thoracic spine bone mineral density (BMD) and severity of coronary artery calcium (CAC) score. The results showed a significant inverse relationship between BMD and CAC in both genders. Further research is needed to explore the underlying pathophysiological mechanisms.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yingnan Song, Ammar Hoori, Hao Wu, Mani Vembar, Sadeer Al-Kindi, Leslie Ciancibello, James G. Terry, David R. R. Jacobs Jr, John Jeffrey Carr, David L. Wilson
Summary: Our goal is to improve CT calcium scores by extracting quantitative features from individual calcifications. We performed deconvolution to improve the bias/reproducibility of small calcification assessments, which can be degraded at the normal CT calcium score image resolution.
JOURNAL OF MEDICAL IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yariv Gerber, Kelley Pettee Gabriel, David R. Jacobs, Jennifer Y. Liu, Jamal S. Rana, Barbara Sternfeld, J. Jeffrey Carr, Paul D. Thompson, Stephen Sidney
Article
Cardiac & Cardiovascular Systems
Vinithra Varadarajan, Samuel S. Gidding, Colin Wu, J. Jeffrey Carr, Joao A. C. Lima
Summary: The increasing prevalence of obesity, hypertension, and diabetes, along with worsening environmental factors, has led to a growing burden of cardiovascular diseases worldwide. Noninvasive imaging techniques, including vascular ultrasound, echocardiography, and magnetic resonance imaging, play a significant role in identifying early cardiovascular disease phenotypes. This article reviews the various imaging modalities used for the evaluation, characterization, and quantification of early subclinical cardiovascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaiwen Xu, Mirza S. Khan, Thomas Z. Li, Riqiang Gao, James G. Terry, Yuankai Huo, Thomas A. Lasko, John Jeffrey Carr, Fabien Maldonado, Bennett A. Landman, Kim L. Sandler
Summary: This study evaluated the added value of CT-based AI-derived body composition measurements in predicting the risk of lung cancer incidence, lung cancer death, cardiovascular disease death, and all-cause mortality. The results showed that these measurements improved the risk prediction for lung cancer death, CVD death, and all-cause mortality, but not for lung cancer incidence.
Article
Medicine, General & Internal
Kathryn Recto, Priyadarshini Kachroo, Tianxiao Huan, David Van Den Berg, Gha Young Lee, Helena Bui, Dong Heon Lee, Jessica Gereige, Chen Yao, Shih-Jen Hwang, Roby Joehanes, George T. O'Cornor, Daniel Levy, Dawn L. DeMeo
Summary: By integrating eQTM and MR analyses in general and clinical asthma populations, our findings provide a deeper understanding of the multidimensional inter-relations of DNA methylation, gene expression, and IgE levels. We identified differentially methylated CpGs associated with IgE levels and replicated them in other populations. We also identified biological pathways related to IgE regulation and proposed CTSB and USP20 as potential therapeutic targets for IgE levels.
Letter
Ophthalmology
Kelvin Y. C. Teo, Gregg Kokame, Srinivas R. Sadda, Satoko Fujimoto, Fumi Gomi, Judy E. Kim, Mark F. S. Cheng, Giulia Corradetti, Anyarak Amornpetchsathaporn, Methaphon Chainakul, Won Ki Lee, Timothy Y. Y. Lai, Paisan Ruamviboonsuk, Chui Ming Gemmy Cheung
OPHTHALMOLOGY RETINA
(2023)