Article
Microbiology
Jingjing Meng, Junyi Tao, Yaa Abu, Daniel Andrew Sussman, Mohit Girotra, Dido Franceschi, Sabita Roy
Summary: Over 37 million people worldwide are living with HIV. Although the availability of antiretroviral therapy has significantly reduced the number of AIDS-related deaths, individuals living with HIV are at increased risk for opportunistic infections. This study characterized compositional and functional shifts in the intestinal and oral microbiome in HIV-positive patients on antiretroviral therapy compared to HIV-negative individuals.
MICROBIOLOGY SPECTRUM
(2023)
Article
Veterinary Sciences
Lynn Verstrepen, Pieter Van den Abbeele, Giulia Pignataro, Cataldo Ribecco, Alessandro Gramenzi, Myriam Hesta, Massimo Marzorati
Summary: This study presents improvements of the Simulator of the Canine Intestinal Microbial Ecosystem (SCIME (TM)), enhancing the simulation of protein digestion and absorption, butyrate production, and levels of Lactobacillus spp. and Bifidobacterium spp. in the colon. Additionally, the implementation of a mucosal environment enriching in Lachnospiraceae members further increased the relevance of the model for canine microbiota studies.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Cell Biology
Friederike Uhlig, Niall P. Hyland
Summary: This review provides an overview of quorum sensing in the gut and summarizes the role of quorum sensing molecules from commensal, probiotic, and pathogenic bacteria in intestinal health and disease. It highlights the importance of further investigation into the mechanisms of action of quorum sensing at the intestinal neuro-immune interface.
Article
Biochemistry & Molecular Biology
Martina Banic, Katarina Butorac, Nina Culjak, Andreja Lebos Pavunc, Jasna Novak, Barbara Bellich, Sasa Kazazic, Snjezana Kazazic, Paola Cescutti, Jagoda Suskovic, Jurica Zucko, Blazenka Kos
Summary: Human milk provides a balanced nutrition and bacteria that contribute to the establishment of infant gut microbiota. Microbiome analysis shows a connection in microbiome composition between mother-milked infant pairs, and the composition of milk and fecal microbiomes change during lactation and infant development. Additionally, human milk contains strains of bacteria that express potential therapeutic biomolecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xin-yu You, Han-yu Zhang, Xu Han, Fang Wang, Peng-wei Zhuang, Yan-jun Zhang
Summary: Interactions between nerves, immune cells, gut microbes, and various receptors play crucial roles in regulating intestinal inflammation and improving mucosal barrier function, which are important therapeutic targets for many diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
Yoowon Kwon, Young-Sun Cho, Yoo-Mi Lee, Seok-jin Kim, Jaewoong Bae, Su-Jin Jeong
Summary: This study evaluated the gut microbiome state in infants following systemic antibiotic treatment. The results showed that the composition of the gut microbiome in the antibiotic treatment group was altered, with increased relative abundance of Escherichia/Shigella and Bifidobacterium, and decreased relative abundance of Bacteroides. Additionally, the antibiotic treatment group had lower microbiome diversity. Long-term studies are needed to further understand the impact of antibiotics on the gut microbiome.
Article
Gastroenterology & Hepatology
Jacob M. Allen, Amy R. Mackos, Robert M. Jaggers, Patricia C. Brewster, Mikaela Webb, Chia-Hao Lin, Chris Ladaika, Ronald Davies, Peter White, Brett R. Loman, Michael T. Bailey
Summary: Psychological stress alters the gut microbiota and increases the risk for enteric infections and chronic bowel conditions. Stress disrupts colonic epithelial cells and mucosal integrity, leading to dysbiosis in the gut microbiota.
Article
Gastroenterology & Hepatology
Patricia P. Bloom, Krishna Rao, Christine Bassis, Borko Nojkov, Vincent B. Young, Anna S. F. Lok
Summary: Patients with cirrhosis have higher duodenal epithelial permeability and lower mucosal bacteria alpha diversity compared to controls, while no such differences are seen in the ileum or colon. Specific bacteria are associated with epithelial permeability and future hepatic decompensation.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Immunology
Jia An, Yuqing Liu, Yiqi Wang, Ru Fan, Xiaorong Hu, Fen Zhang, Jinhua Yang, Junwei Chen
Summary: Autoimmune diseases involve multiple tissues and organs, and the specific pathogenesis is not fully understood. The impaired intestinal mucosal barrier can disrupt immune homeostasis and trigger inflammation. However, the mechanisms by which the intestinal mucosal barrier regulates immune homeostasis and inflammation are not clear.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Su-Min Baek, Tae-Un Kim, Young-Jin Lee, Seoung-Woo Lee, Jae-Hyuk Yim, Woo Jun Kim, Hee-Yeon Kim, Kyung-Ku Kang, Sung Dae Kim, Sang-Joon Park, Seong-Kyoon Choi, Jin-Kyu Park
Summary: This study aimed to investigate the correlation between alcohol consumption and organ distributions of microplastics in an ethanol feeding animal model. The results showed that alcohol intake exacerbated the accumulation of microplastics in the liver, intestines, spleen, and brain, with the intestines experiencing the most severe damage. Additionally, the study revealed that hepatic steatosis was more severe in the group with alcohol and microplastics.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Agriculture, Dairy & Animal Science
Jin-A Lim, Jihye Cha, Soyoung Choi, Jae-Hwan Kim, Dahye Kim
Summary: This study investigated changes in piglet fecal microbiomes from birth through weaning and their associations with sows. The results revealed that certain bacterial groups dominated early piglet microbiomes during nursing, and an increase in specific bacteria was observed in weaned piglets fed solid feed. The study also suggested that the piglet intestinal microbiome is vertically transmitted from the mother. Further research is needed to better understand the early establishment of piglet intestinal microbiomes by considering factors related to sows, piglets, and the environment.
Article
Pharmacology & Pharmacy
Jiayi Tian, Chaoying Yan, Yanfang Jiang, Haohan Zhou, Liyuan Li, Jingjing Shen, Jian Wang, Hongyu Sun, Guang Yang, Wei Sun
Summary: The study found that mucosal-associated invariant T (MAIT) cells accumulate in the inflammatory intestinal tissues of necrotizing enterocolitis (NEC) patients, while the percentage of CD8αα(+) MAIT cells is significantly reduced. After treatment, the frequency of circulating MAIT cells in NEC patients significantly increases. The research results indicate the important role of MAIT cells in the pathogenesis of NEC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Yuchen Liu, Lianhong Li, Huaxiang Yan, Zhonghua Ning, Zhong Wang
Summary: The study demonstrated that supplementing L. salivarius SNK-6 can improve feed intake and disease resistance in laying hens, but may lead to changes in production performance. This immunomodulatory function is possibly achieved by regulating the cecal microbial composition.
Article
Immunology
Mehmet Davrandi, Stephanie Harris, Philip J. Smith, Charles D. Murray, David M. Lowe
Summary: This study found that the microbiome in CGD-associated colitis patients showed reduced taxonomic alpha-diversity compared to unaffected patients, even in apparently normal bowel segments. Metabolic pathways involved in butyrate biosynthesis or utilization were enriched in colitis patients and correlated positively with fecal calprotectin levels. Additionally, the microbiome appeared to influence the inflammatory phenotype of CGD independent of colitis status.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shingo Bessho, Kaitlyn C. M. Grando, Kathrine Kyrylchuk, Amanda Miller, Andres J. Klein-Szanto, Wenhan Zhu, Stefania Gallucci, Vincent Tam, Cagla Tukel
Summary: This study found that mice from Taconic Farms, which have higher levels of inflammatory cytokines, exhibited significantly aggravated immune responses after being injected with purified curli compared to mice from Jackson Labs. The results suggest that differences in microbiota can influence the exacerbation of autoimmune responses.
Article
Virology
Ellen Wu, Yueqi Du, Xiang Gao, Jie Zhang, John Martin, Makedonka Mitreva, Lee Ratner
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Rahul Tyagi, Mostafa A. Elfawal, Scott A. Wildman, Jon Helander, Christina A. Bulman, Judy Sakanari, Bruce A. Rosa, Paul J. Brindley, James W. Janetka, Raffi Aroian, Makedonka Mitreva
SCIENTIFIC REPORTS
(2019)
Review
Genetics & Heredity
Douglas P. Jasmer, Bruce A. Rosa, Rahul Tyagi, Makedonka Mitreva
FRONTIERS IN GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Young-Jun Choi, Santiago Fontenla, Peter U. Fischer, Thanh Hoa Le, Alicia Costabile, David Blair, Paul J. Brindley, Jose F. Tort, Miguel M. Cabada, Makedonka Mitreva
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
Article
Immunology
Lucja A. Labuda, Ayola A. Adegnika, Bruce A. Rosa, John Martin, Ulysse Ateba-Ngoa, Abena Serwaa Amoah, Honorine Mbenkep Lima, Lynn Meurs, Moustapha Mbow, Mikhael D. Manurung, Jeannot F. Zinsou, Hermelijn H. Smits, Peter G. Kremsner, Makedonka Mitreva, Maria Yazdanbakhsh
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Immunology
Jose Alberto Choreno-Parra, Suhas Bobba, Javier Rangel-Moreno, Mushtaq Ahmed, Smriti Mehra, Bruce Rosa, John Martin, Makedonka Mitreva, Deepak Kaushal, Joaquin Zuniga, Shabaana A. Khader
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Cell Biology
Mushtaq Ahmed, Shyamala Thirunavukkarasu, Bruce A. Rosa, Kimberly A. Thomas, Shibali Das, Javier Rangel-Moreno, Lan Lu, Smriti Mehra, Stanley Kimbung Mbandi, Larissa B. Thackray, Michael S. Diamond, Kenneth M. Murphy, Terry Means, John Martin, Deepak Kaushal, Thomas J. Scriba, Makedonka Mitreva, Shabaana A. Khader
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Microbiology
Bruce A. Rosa, Kathie Mihindukulasuriya, Kymberlie Hallsworth-Pepin, Aye Wollam, John Martin, Caroline Snowden, William Michael Dunne, George M. Weinstock, Carey-Ann D. Burnham, Makedonka Mitreva
Article
Infectious Diseases
Jayden Logan, Mark S. Pearson, Srikanth S. Manda, Young-Jun Choi, Matthew Field, Ramon M. Eichenberger, Jason Mulvenna, Shivashankar H. Nagaraj, Ricardo T. Fujiwara, Pedro Gazzinelli-Guimaraes, Lilian Bueno, Vitor Mati, Jeffrey M. Bethony, Makedonka Mitreva, Javier Sotillo, Alex Loukas
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Infectious Diseases
Douglas P. Jasmer, Bruce A. Rosa, Rahul Tyagi, Christina A. Bulman, Brenda Beerntsen, Joseph F. Urban, Judy Sakanari, Makedonka Mitreva
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Microbiology
Rahul Tyagi, Christina A. Bulman, Fidelis Cho-Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R. Arkin, James H. McKerrow, Case W. McNamara, Matthew Mahoney, Nancy Tricoche, Shabnam Jawahar, James W. Janetka, Sara Lustigman, Judy Sakanari, Makedonka Mitreva
Summary: 18 hits with anti-macrofilaricidal activity were identified, with azoles and aspartic protease inhibitors being prioritized for further study. These drugs showed activity against Onchocerca spp. as well, with the potential to identify selective drugs that prevent adverse events in co-infected individuals.
Article
Food Science & Technology
Sandra Martinez-Puchol, Maribel Riveros, Kenny Ruidias, Ana Granda, Lidia Ruiz-Roldan, Cristhian Zapata-Cachay, Theresa J. Ochoa, Maria J. Pons, Joaquim Ruiz
Summary: This study aimed to characterize Salmonella enterica serovar Infantis isolated from chicken meat and found that these bacteria were multidrug-resistant, with clonal relationships to S. Infantis causing diarrhea in children. The dissemination of MDR S. Infantis between marketed meat and children highlights a public health problem that needs to be controlled at the livestock level.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Review
Environmental Sciences
Maria Luisa Medina-Pizzali, Stella M. Hartinger, Gabriela Salmon-Mulanovich, Anika Larson, Maribel Riveros, Daniel Mausezahl
Summary: This study highlights the limited understanding of antimicrobial resistance in rural Latin America, with a focus on contributions from animal production and agricultural practices. Livestock, including poultry, swine, cattle, and fish, were identified as common sources of AMR bacteria, with animal carriage and environmental factors playing significant roles in transmission. More One Health-oriented studies are needed to better understand the interconnected transmission routes and prevent further emergence of AMR in rural Latin America.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Microbiology
Liana Beld, Hyeim Jung, Christina A. Bulman, Bruce A. Rosa, Peter U. Fischer, James W. Janetka, Sara Lustigman, Judy A. Sakanari, Makedonka Mitreva
Summary: Current treatments for lymphatic filariasis and onchocerciasis are not effective in killing the adult parasitic nematodes. Researchers have found that certain HIV antiretroviral drugs, specifically aspartyl protease inhibitors, show potential in killing adult filarial nematodes. Nelfinavir had the best potency in killing the nematodes, followed by ritonavir and lopinavir. These findings suggest that these drugs could be explored as potential treatments for parasitic nematode infections.
Article
Infectious Diseases
Katherine Alcedo, Joaquim Ruiz, Theresa J. Ochoa, Maribel Riveros
Summary: This study demonstrates a high prevalence of ESBL-carriers among healthy children living in a rural area of Peru, highlighting the need for continuous surveillance and search for public health control measures.
INFECTION AND CHEMOTHERAPY
(2022)