期刊
AMERICAN JOURNAL OF SURGERY
卷 218, 期 6, 页码 1065-1073出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2019.08.024
关键词
Blunt solid organ injury; Thrombelastography; Thrombosis; Hypercoagulability
类别
资金
- National Institute of General Medical Sciences of the National Institutes of Health [T32 GM008315, P50 GM049222]
- US Department of Defense (USAMRAA) [W81XWH-12-2-0028]
- Intermountain Research and Medical Foundation
Introduction: The optimal time to initiate venous thromboembolism (VTE) chemoprophylaxis in blunt solid organ injury (BSOI) patients is debated. We hypothesize that 1) BSOI patients are hypercoagulable within 12 h of injury and 2) hypercoagulability dominates in patients who develop clot complications (CC). Material and methods: This is a prospective study of BSOI patients admitted to two Level-1 Trauma Centers' trauma intensive care units (ICU). Serial kaolin thrombelastography (TEG) and tissue plasminogen activator (tPA)-challenge TEGs were performed. CC included VTE and cerebrovascular accidents. Results: On ICU admission, all patients (n = 95) were hypercoagulable, 58% were in fibrinolysis shutdown, and 50% of patients were tPA-resistant. Twelve patients (13%) developed CC. Compared to those without CC, they demonstrated decreased fibrinolysis at 12 h and higher clot strength at 48 h Conclusions: BSOI patients are universally hypercoagulable upon ICU admission. VTE chemoprophylaxis should be started immediately in BSOI patients with hypercoagulability on TEG. (C) 2019 Elsevier Inc. All rights reserved.
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