期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 317, 期 5, 页码 G602-G608出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00230.2019
关键词
dysbiosis; homeostasis; microbiome; microbiota
资金
- U.S. Department of Agriculture/National Institute of Food and Agriculture [2015-6701522930]
- Public Health Service [AI044170, AI096528, AI112445, AI112949]
Advances in data collection technologies reveal that an imbalance (dysbiosis) in the composition of host-associated microbial communities (microbiota) is linked to many human illnesses. This association makes dysbiosis a central concept for understanding how the human microbiota contributes to health and disease. However, it remains problematic to define the term dysbiosis by cataloguing microbial species names. Here, we discuss how incorporating the germ-organ concept, ecological assumptions, and immunological principles into a theoretical framework for microbiota research provides a functional definition for dysbiosis. The generation of such a framework suggests that the next logical step in microbiota research will be to illuminate the mechanistic underpinnings of dysbiosis, which often involves a weakening of immune mechanisms that balance our microbial communities.
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