Article
Clinical Neurology
Julien Delrieu, Bruno Vellas, Sophie Guyonnet, Christelle Cantet, Vitaliy Ovod, Yan Li, James Bollinger, Randall Bateman, Sandrine Andrieu, MAPT DSA Grp
Summary: The study demonstrated a positive cognitive effect of MI plus omega 3 in subjects with positive blood amyloid, but further confirmation is needed. Conversely, no cognitive effect was observed in both positive and negative blood amyloid groups at the 60-month visit.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Nadege Costa, M. Mounie, A. Pages, H. Derumeaux, T. Rapp, S. Guyonnet, N. Coley, C. Cantet, I. Carrie, S. Andrieu, L. Molinier
Summary: Efforts focusing on prevention strategies to improve the efficiency of healthcare systems for Alzheimer's disease, with the aim of assessing the cost-effectiveness of three preventive strategies compared to a placebo.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Backman, Tuomo Hanninen, Jaana Lindstrom, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Summary: Active participation in multidomain lifestyle interventions is associated with better cognitive functioning, especially in overall cognition and executive function. Future interventions should be more intensive and support adherence to lifestyle changes.
ALZHEIMERS & DEMENTIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian J. Burkett, Jeffrey C. Babcock, Val J. Lowe, Jonathan Graff-Radford, Rathan M. Subramaniam, Derek R. Johnson
Summary: PET imaging plays an essential role in the earlier and more specific diagnoses of dementia syndromes, especially with the development of pathology-specific disease-modifying therapy for Alzheimer disease. Amyloid and tau PET techniques have entered clinical use, making nuclear medicine physicians and radiologists crucial members of the care team. This review discusses recent changes in the understanding of dementia and examines the roles of nuclear medicine imaging in clinical practice.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Jordi Pegueroles, Victor Montal, Alexandre Bejanin, Eduard Vilaplana, Mateus Aranha, Miguel Angel Santos-Santos, Daniel Alcolea, Ignasi Carrio, Valle Camacho, Rafael Blesa, Alberto Lleo, Juan Fortea
Summary: The AMYQ index is a new MRI-independent measure for standardizing and quantifying amyloid burden, with high agreement with the Centiloid scale and excellent diagnostic performance for discriminating patients with Alzheimer's disease from controls.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Pawel J. Markiewicz, Julian C. Matthews, John Ashburner, David M. Cash, David L. Thomas, Enrico De Vita, Anna Barnes, M. Jorge Cardoso, Marc Modat, Richard Brown, Kris Thielemans, Casper Da Costa-Luis, Isadora Lopes Alves, Juan Domingo Gispert, Mark E. Schmidt, Paul Marsden, Alexander Hammers, Sebastien Ourselin, Frederik Barkhof
Summary: The precision of MR-PET image registration is mainly driven by the registration implementation and the quality of PET images, with different software packages and reconstruction parameters having varying impacts on the uncertainty. This analysis provides insights into the factors influencing the accuracy of PET data obtained from different scanning techniques.
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvio R. Meier, Dag Sehlin, Sahar Roshanbin, Victoria Lim Falk, Takashi Saito, Takaomi C. Saido, Ulf Neumann, Johanna Rokka, Jonas Eriksson, Stina Syvanen
Summary: This study compared an antibody-based PET ligand with C-11-PiB for the detection of nonfibrillar A beta in Alzheimer disease mouse models. The results showed that the antibody-based ligand could detect changes in brain A beta levels after anti-A beta therapy, while C-11-PiB was unable to quantify the decreased A beta levels.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ruggero Bacchin, Matteo Salgarello, Michela Trentin, Giampietro Zanette, Stefano Tamburin
Summary: FXTAS is a rare movement disorder caused by a 55-to-200 CGG-trinucleotide expansion premutation in the FMR1 gene, with core diagnostic criteria of tremor, ataxia, and T2-weighted hyperintensity of the middle cerebellar peduncles on MRI. The pathophysiology of FXTAS is largely unknown, with possible overlap with Alzheimer disease according to some animal models and neuropathology findings.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Cell Biology
Seo-Hyun Kim, Young-Sin Cho, Youbin Kim, Jisu Park, Seung-Min Yoo, Jimin Gwak, Youngwon Kim, Youngdae Gwon, Tae-in Kam, Yong-Keun Jung
Summary: Impaired endolysosomal integrity plays a crucial role in the development of Alzheimer's disease (AD). The vacuolar ATPase (V-ATPase) complex acts as a proteotoxic receptor that binds to amyloid beta (Aβ) and hyperphosphorylated MAPT/Tau (p-MAPT/Tau), leading to endolysosomal dysfunction and subsequent neurodegeneration. The identification of HYAL as a suppressor of endolysosomal dysfunction provides potential therapeutic targets for AD treatment. Additionally, the interaction between hyaluronic acid (HA) and its receptor CD44 may alleviate neurotoxicity in affected neurons via V-ATPase.
Article
Clinical Neurology
Anders Rydstrom, Alexander Darin-Mattsson, Ingemar Kareholt, Tiia Ngandu, Jenni Lehtisalo, Alina Solomon, Riitta Antikainen, Lars Backman, Tuomo Hanninen, Tiina Laatikainen, Esko Levalahti, Jaana Lindstrom, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Shireen Sindi, Hilkka Soininen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Francesca Mangialasche
Summary: Higher levels of occupational complexity are associated with better baseline cognition. However, the cognitive benefit of intervention did not vary significantly among participants with different levels of occupational complexity, except for occupational complexity related to data being associated with gains in executive function.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Ariane Bollack, Pawel J. Markiewicz, Alle Meije Wink, Lloyd Prosser, Johan Lilja, Pierrick Bourgeat, Jonathan M. Schott, William Coath, Lyduine E. Collij, Hugh G. Pemberton, Gill Farrar, Frederik Barkhof, David M. Cash
Summary: This study evaluated the performance of four novel data-driven metrics against conventional techniques for quantifying amyloid-beta (Aβ) pathology. The results showed that the Aβ load, Aβ index, and CLNMF metrics can provide comparable performance to established quantification methods. These new metrics may offer more precise alternatives and further studies in larger cohorts should be conducted.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Neurosciences
Alina Solomon, Ron Handels, Anders Wimo, Riitta Antikainen, Tiina Laatikainen, Esko Levalahti, Markku Peltonen, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Tiia Ngandu
Summary: The study demonstrates that a multidomain lifestyle intervention can reduce the risk of cognitive impairment in older adults, indicating the preventive potential of the intervention.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Johannes Levin, Jonathan Voglein, Yakeel T. Quiroz, Randall J. Bateman, Valentina Ghisays, Francisco Lopera, Eric McDade, Eric Reiman, Pierre N. Tariot, John C. Morris
Summary: The amyloid cascade hypothesis for Alzheimer's disease has faced challenges due to inconsistent clinical benefits of drugs targeting amyloid beta peptide. It is important to conduct intervention studies in cognitively unimpaired individuals at risk for dementia to further evaluate the hypothesis.
ALZHEIMERS & DEMENTIA
(2022)
Article
Cell Biology
Julian M. Carosi, Leanne K. Hein, Mark van den Hurk, Robert Adams, Bridget Milky, Sanjna Singh, Cedric Bardy, Donna Denton, Sharad Kumar, Timothy J. Sargeant
Summary: The autophagy-lysosome axis is crucial for the clearance of MAPT aggregates, with dysfunction of the central retromer component VPS35 leading to impaired autophagic resolution and accumulation of cytoplasmic MAPT aggregates. Maintaining the integrity of the retromer complex regulates the autophagy-lysosome axis to suppress MAPT aggregation and propagation.
Correction
Geriatrics & Gerontology
J. G. Ruiz, E. Dent, John E. Morley, R. A. Merchant, J. Beilby, J. Beard, C. Tripathy, M. Sorin, S. Andrieu, I. Aprahamian, H. Arai, M. Aubertin-Leheudre, J. M. Bauer, M. Cesari, L. -K. Chen, A. J. Cruz-Jentoft, P. De Souto Barreto, B. Dong, L. Ferrucci, R. Fielding, L. Flicker, J. Lundy, J. Y. Reginster, L. Rodriguez-Manas, Y. Rolland, A. M. Sanford, A. J. Sinclair, J. Vina, D. L. Waters, C. Won Won, J. Woo, B. Vellas
Summary: Apology for a typing error changing the meaning of a sentence in the September 2020 article.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Clinical Neurology
Thibault Mura, Nicola Coley, Helene Amieva, Claudine Berr, Audrey Gabelle, Pierre-Jean Ousset, Bruno Vellas, Sandrine Andrieu
Summary: The study compared the validity of various cognitive and functional markers in predicting incident dementia among elderly with memory loss. Results showed that the Free and Cued Selective Reminding Test-Free Recall (FCSRT-FR) score had the highest predictive value, along with other cognitive scores, while some other markers like Mini-Mental State Examination did not significantly predict dementia occurrence.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Sylvie Belleville, Simon Cloutier, Samira Mellah, Sherry Willis, Bruno Vellas, Sandrine Andrieu, Nicola Coley, Tiia Ngandu
Summary: This study examines the dose-response relationship in multidomain interventions for dementia prevention and finds that the optimal dose is about half of the potentially available sessions. Factors such as gender, age, frailty, education level, and dementia risk influence individuals' response to the dose.
ALZHEIMERS & DEMENTIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuliya Piatkova, Pierre Payoux, Caroline Boursier, Manon Bordonne, Veronique Roch, Pierre-Yves Marie, Gabriela Hossu, Laetitia Imbert, Antoine Verger
Summary: This study compared I-123-FP-CIT SPECT imaging obtained from a 360 degrees CZT camera with different focus configurations to that from a conventional Anger camera. The results showed that the 360 degrees CZT camera provided higher image quality, shorter acquisition times, and fewer discordant cases compared to the conventional camera, possibly due to its higher spatial resolution.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Neurosciences
Dominique Gouilly, Laure Saint-Aubert, Maria-Joao Ribeiro, Anne-Sophie Salabert, Clovis Tauber, Patrice Peran, Nicolas Arlicot, Jeremie Pariente, Pierre Payoux
Summary: This review provides an update on the results from 2018 and advances the characterization of TSPO imaging in Alzheimer's disease (AD) by re-examining TSPO function and expression. Although the biological basis of the TSPO PET signal is clearly related to microglia and astrocytes in AD, the exact process remains uncertain and may not be directly associated with neuroinflammation. Further studies are needed to explore the cellular significance underlying variations in the PET signal in AD.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Retraction
Geriatrics & Gerontology
Bertrand Fougere, Sabine Goisser, Christelle Cantet, Gaelle Soriano, Sophie Guyonnet, Philipe De Souto Barreto, Matteo Cesari, Sandrine Andrieu, Bruno Vellas
Article
Medicine, General & Internal
Anis Krache, Charlotte Fontan, Carine Pestourie, Manuel Bardies, Yann Bouvet, Pierre Payoux, Etienne Chatelut, Melanie White-Koning, Anne-Sophie Salabert
Summary: Anti-PDL1 is a monoclonal antibody that restores the immune system response in several tumors by targeting PD-L1. Non-invasive imaging enables whole-body mapping of PD-L1 sites and could improve the assessment of tumor PD-L1 expression.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Clinical Neurology
Sylvie Belleville, Simon Cloutier, Samira Mellah, Bruno Vellas, Sandrine Andrieu, Nicola Coley, Tiia Ngandu
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Chadlia Karoui, Kuzma Strelnikov, Pierre Payoux, Anne-Sophie Salabert, Chris J. James, Olivier Deguine, Pascal Barone, Mathieu Marx
Summary: Cochlear implantation can restore the normal functional pattern of auditory cortical activity and improve sound localization in individuals with asymmetric hearing loss (AHL). The contralateral dominance for the nonimplanted ear strongly correlates with sound localization performance.
Meeting Abstract
Cardiac & Cardiovascular Systems
Laure Rouch, Yves Rolland, Olivier Hanon, Jean-Sebastien Vidal, Philippe CESTAC, Brigitte SALLERIN, Sandrine Andrieu, Bruno Vellas, Philipe de Souto Barreto
Article
Health Care Sciences & Services
Nicola Coley, Laurine Andre, Marieke P. Hoevenaar-Blom, Tiia Ngandu, Cathrien Beishuizen, Mariagnese Barbera, Lennard van Wanrooij, Miia Kivipelto, Hilkka Soininen, Willem van Gool, Carol Brayne, Eric Moll van Charante, Edo Richard, Sandrine Andrieu
Summary: This study aimed to examine older adults' engagement with a digital health intervention and its associations with changes in cardiovascular and dementia risk factors. The findings showed that higher engagement was associated with greater improvement in risk factors. However, individuals with limited computer experience, lower education levels, or poorer cognition tended to have lower engagement.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Geriatrics & Gerontology
Emmanuel Gonzalez-Bautista, Philipe de Souto Barreto, Aaron Salinas-Rodriguez, Betty Manrique Espinoza, Sandrine Sourdet, Yves Rolland, Leocadio Rodriguez-Manas, Sandrine Andrieu, Bruno Vellas
Summary: This study developed age-stratified chair stand cutoffs to assess locomotion capacity in older adults. The cutoffs of 14 seconds and 16 seconds were found to be suitable in identifying individuals at higher risk of functional decline in Mexico and Toledo, Spain.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Laure Rouch, Yves Rolland, Olivier Hanon, Jean-Sebastien Vidal, Philippe Cestac, Brigitte Sallerin, Sandrine Andrieu, Bruno Vellas, Philipe De Souto Barreto, MAPT DSA Grp
Summary: Low blood pressure is associated with an increased risk of frailty in older adults, especially those who are on two or more antihypertensive drugs. High blood pressure and antihypertensive drug use are not independently associated with incident frailty.
Article
Geriatrics & Gerontology
Neda Tavassoli, Philipe de Souto Barreto, Caroline Berbon, Celine Mathieu, Justine de Kerimel, Christine Lafont, Catherine Takeda, Isabelle Carrie, Antoine Piau, Tania Jouffrey, Sandrine Andrieu, Fatemeh Nourhashemi, John R. Beard, Maria Eugenia Soto Martin, Bruno Vellas
Summary: This study describes the large-scale implementation and feasibility of the INSPIRE ICOPE-CARE guidelines in clinical practice, and suggests that the INSPIRE ICOPE-CARE program is able to target individuals who are at increased risk for functional loss and disability.
LANCET HEALTHY LONGEVITY
(2022)
Article
Clinical Neurology
M. G. H. E. den Brok, M. P. Hoevenaar-Blom, N. Coley, S. Andrieu, J. van Dalen, Y. Meiller, J. Guillemont, C. Brayne, W. A. van Gool, E. P. Moll van Charante, E. Richard
Summary: This study pooled individual participant data from two multidomain intervention trials and found that these interventions did not reduce the risk of global cognitive decline, symptoms of depression, or apathy in the overall older population. However, in individuals with lower baseline cognitive functioning, the intervention groups showed less decline in cognitive function. Extended follow-up for dementia occurrence is important to understand the potential long-term effects of multidomain interventions.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
