期刊
ALLERGY
卷 75, 期 3, 页码 576-587出版社
WILEY
DOI: 10.1111/all.14047
关键词
antiviral response; lambda-interferones; nasal symptoms; nonallergenic pollen compounds; respiratory syncytial virus; rhinovirus
资金
- Christine-KuhneCenter for Allergy Research and Education (CK-Care)
- Bayerische Forschungsstiftung (BFS)
- Medical Research Council (UK) [G0900453]
- EUCOST Action DiMoPEx (Diagnosis, Monitoring and Prevention of Exposure-Related Noncommunicable Diseases) [CA15129]
- Helmholtz Association, Germany: Impulsund Vernetzungsfonds (IVF)
- MRC [G0900453] Funding Source: UKRI
- NERC [NE/T002069/1] Funding Source: UKRI
BackgroundHundreds of plant species release their pollen into the air every year during early spring. During that period, pollen allergic as well as non-allergic patients frequently present to doctors with severe respiratory tract infections. Our objective was therefore to assess whether pollen may interfere with antiviral immunity. MethodsWe combined data from real-life human exposure cohorts, a mouse model and human cell culture to test our hypothesis. ResultsPollen significantly diminished interferon-lambda and pro-inflammatory chemokine responses of airway epithelia to rhinovirus and viral mimics and decreased nuclear translocation of interferon regulatory factors. In mice infected with respiratory syncytial virus, co-exposure to pollen caused attenuated antiviral gene expression and increased pulmonary viral titers. In non-allergic human volunteers, nasal symptoms were positively correlated with airborne birch pollen abundance, and nasal birch pollen challenge led to downregulation of type I and -III interferons in nasal mucosa. In a large patient cohort, numbers of rhinoviruspositive cases were correlated with airborne birch pollen concentrations. ConclusionThe ability of pollen to suppress innate antiviral immunity, independent of allergy, suggests that high-risk population groups should avoid extensive outdoor activities when pollen and respiratory virus seasons coincide.
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