期刊
AGING-US
卷 11, 期 18, 页码 7938-7947出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.102299
关键词
aging; fish oil; marrow adipose tissue; osteoporosis; SAMP8 mouse
资金
- Australian Institute for Musculoskeletal Science (AIMSS)
- Australian Medical Research Frontiers Fund Fellowship (MRFF: MACH-RART scheme 2019)
Purpose: Marrow adipose tissue (MAT) expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow (HBM) atrophy. Fish oil and borage oil (rich in omega 3 fatty acids) can partially prevent aged-related bone loss in SAMP8 mice. However, whether preservation of bone mass in this progeria model is associated with MAT volumes remains unknown. Results: MAT volume fraction (MAT%) showed a negative association with hematopoietic bone marrow (HBM%; r=-0.836, p<0.001) and bone (bone%; r=-0.344, p=0.013) volume fractions. Adjusting for multiple comparisons, bone% was higher and MAT% was lower in Fish oil (FO)-supplemented groups vs. controls (p<0.001). HBM% did not differ significantly between the four groups. However, in the group supplemented with FO, HBM comprised higher fractions and MAT constituted lower fractions of total marrow vs. controls (p<0.001). Conclusion: Feeding FO-enriched diet prevented age-related bone and HBM loss, by reducing MAT expansion. Our results further emphasize on the role(s) of MAT expansion in bone and HBM atrophy. Methods: SAMP8 mice (n>9 /group) were allocated into 4 categories and fed a control ration, FO-, sunflower oil (SFO)- and borage oil-enriched diets for lifetime. Femurs were scanned using microcomputed tomography (mu CT) and bone, MAT, and HBM volumes were determined using an image analysis software.
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