Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mahla Lashkari, Mahya Rahmani, Yaser Yousefpoor, Meysam Ahmadi-Zeidabadi, Reza Faridi-Majidi, Zahra Ameri, Moein Salary, Shahrzad Azizi, Arman Shahabi, Amid Rahi, Mohamad Javad Mirzaei-Parsa
Summary: In this study, a bilayer scaffold composed of hydrogel and nanofibers was fabricated to improve the regeneration of injured skin. The results showed that re-epithelialization, angiogenesis, and collagen remodeling were enhanced in ADSCs-seeded bilayer scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Xiaowen Fu, Yue Chen, Gan Hu, Jiran Lv, Jihong Liu, Meihu Ma, Xing Fu
Summary: Here, a silver ion cross-linked thiolated protein hydrogel was prepared, which showed significant effects on the healing of acute wounds and has promising applications in the field of bioengineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Liu Qu, Nileshkumar Dubey, Juliana S. Ribeiro, Ester A. F. Bordini, Jessica A. Ferreira, Jinping Xu, Rogerio M. Castilho, Marco C. Bottino
Summary: The study engineered metformin-loaded mesoporous silica nanospheres laden gelatin methacryloyl photocrosslinkable hydrogels, which demonstrated potential osteogenic effects on stem cells. Through testing mechanical properties, drug release, cytocompatibility, and osteogenic differentiation, the hydrogels showed promise for bone regeneration applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Huijuan Wang, Deshun Sun, Weiming Lin, Chao Fang, Kui Cheng, Zhengzhou Pan, Daping Wang, Zhangfa Song, Xiaojun Long
Summary: This article introduces a one-step fabrication of a cell sheet-laden hydrogel (CSH) for the complete repair and regeneration of full-thickness skin defects. The results showed that CSH promotes wound closure and accelerates mature granulation and dermis formation within 14 days. This research provides guidance and strategies for the complete repair and regeneration of full-thickness skin defects and has great potential for tissue regeneration in clinical applications.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Shunxian Ji, Yushuang Zhao, Xinrang Zhai, Lu Wang, Huali Luo, Zhiyong Xu, Wei Dong, Bingbing Wu, Wei Wei
Summary: This study designed a double-crosslinked hydrogel for wound dressing using photocrosslinkable gelatin methacryloyl (GelMA) and sulfhydrylated chitosan (CS-SH). The resulting hydrogels showed a highly porous inner structure, enhanced mechanical properties, and moisture retention capacity. In vitro studies showed no cytotoxicity and promoted cell proliferation. The double-crosslinked hydrogel also exhibited antibacterial properties and accelerated full-thickness skin defect healing in animal experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Xiaomin Luo, Fen Ao, Qianqian Huo, Ying Liu, Xuechuan Wang, Huijie Zhang, Min Yang, Yun Ma, Xinhua Liu
Summary: This study developed a skin-inspired gelatin/HA-based injectable remoistenable adhesive hydrogel with excellent physical properties and biological effects to improve wound healing, which has significant implications.
BIOMATERIALS ADVANCES
(2022)
Article
Polymer Science
Gwijae Kim, Young-Gwang Ko, Hyeyoung Lee, Ho Yun Chung, Oh Hyeong Kwon
Summary: The Gel-Tyr hydrogel prepared through an enzymatic crosslinking reaction showed promising properties as a sprayable wound dressing, with rapid gelation rate and accelerated wound healing abilities demonstrated in in vivo animal experiments and histological evaluations.
Article
Chemistry, Applied
Amin Sadeghi, Maryam Zare-Gachi, Mostafa Najjar-Asl, Sarah Rajabi, Mohammad Javad Fatemi, Siamak Farokh Forghani, Hamed Daemi, Mohamad Pezeshki-Modaress
Summary: In this study, a novel biodegradable gelatin/sulfated alginate hybrid scaffold was introduced as a dermal substitute for accelerating the healing of full-thickness diabetic foot ulcers in a diabetic mouse model. The hybrid scaffold exhibited no cytotoxicity and promoted cell growth with increasing sulfated alginate content. The pathology results showed that the hybrid scaffolds-treated wounds had more appropriate epidermal layer formation, more homogeneous distribution of collagenous tissue, and lower immune cell penetration.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Hang Dong, Jian Li, Xueyuan Huang, Haiting Liu, Rong Gui
Summary: This study developed a novel multifunctional hydrogel, Pltm@CNPs/Gel, which incorporates platelet membrane camouflaged cerium nanoparticles into a gelatin methacryloyl matrix. The Pltm@CNPs/Gel hydrogel possesses anti-oxidative and anti-inflammatory properties and accelerates diabetic wound healing by promoting neovascularization, cell proliferation, and collagen fiber organization. The hydrogel shows potential as a therapeutic option for diabetic wound healing and as a diabetic wound dressing candidate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Tyler Gregory, Prateek Benhal, Annie Scutte, David Quashie Jr, Kiram Harrison, Casey Cargill, Saliya Grandison, Mary Jean Savitsky, Subramanian Ramakrishnan, Jamel Ali
Summary: Increasing cell seeding densities have shown an inverse relationship with shear viscosity and a reduction in storage moduli, leading to lowered printing pressures for gel extrusion. However, higher cell concentrations may negatively impact the structural properties of the extruded material.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Zenab Darban, Hemant Singh, Udisha Singh, Dhiraj Bhatia, Rama Gaur, Muzammil Kuddushi, Mukesh Dhanka, Syed Shahabuddin
Summary: A biological macromolecules-based hydrogel dressing has been developed for treating burn wounds. The hydrogel exhibited excellent antioxidant and antibacterial properties, high cell compatibility, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Engineering, Biomedical
Yuanmeng He, Kaiyue Liu, Shen Guo, Rong Chang, Chen Zhang, Fangxia Guan, Minghao Yao
Summary: A multifunctional hydrogel (OGF) based on oxidized dextran, gallic acid-grafted gelatin, and Ferric ion showed excellent antibacterial ability and promoted the healing of infected wounds in diabetic patients.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Yan Huang, Na Yang, Da Teng, Ruoyu Mao, Ya Hao, Xuanxuan Ma, Lingyun Wei, Jianhua Wang
Summary: In this study, three-dimensional reticulated antimicrobial peptide hydrogels were developed for preventing and treating Staphylococcus aureus infections. The HPC-NZ2114 hydrogel exhibited sustained release, good cytocompatibility, and excellent antibacterial activity both in vitro and in vivo. It accelerated wound healing by reducing inflammation and promoting angiogenesis.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jie Zhu, Zhixiao Liu, Ling Wang, Qishu Jin, Yunpeng Zhao, Antong Du, Neng Ding, Yue Wang, Hua Jiang, Lie Zhu
Summary: Loading human umbilical mesenchymal stem cell (hUMSC) derived exosome mimetics onto hydrogel scaffolds promotes wound healing more efficiently than exosome-loaded hydrogels. Exosome mimetics can enhance the proliferation and migration of dermal fibroblasts, potentially through enriching mitochondrial-derived oxidative phosphorylation-related proteins. Thus, exosome mimetics have promising potential as candidates for exosomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
