期刊
ACS OMEGA
卷 4, 期 6, 页码 10891-10898出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.9b01145
关键词
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资金
- DST [SB/S1/OC-94/2013]
- IIT Kharagpur
- ICMR
A method for rapid detection of metallo-beta-lactamases NDM-5 and NDM-7 using conjugates of azidonaphthalimide and Zn(II) chelating motifs (like sulfonamides, hydroxamate, and terpyridine) is described. Incubation and irradiation, followed by gel electrophoresis, clearly show the presence of NDMs. The o-sulfonamide-based probe has the highest efficiency of detection for both the NDMs. The proteins are detectable at nM concentrations, and the method is also selective, works both in vitro and in vivo, as revealed by cellular imaging and also with clinical isolates.
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