Article
Toxicology
Sarah McCarrick, Valentin Romanovski, Zheng Wei, Elin M. Westin, Kjell-Arne Persson, Klara Trydell, Richard Wagner, Inger Odnevall, Yolanda S. Hedberg, Hanna L. Karlsson
Summary: The study demonstrates that welding particles generated using optimized Cr(VI)-reduced wires are less toxic compared to standard welding wires, showing reduced cytotoxicity and no DNA damage. The release of Cr(VI) from standard wires in cell media seemed to explain most of the cytotoxicity and DNA damage. Different welding particles caused similar inflammatory effects, suggesting different underlying mechanisms.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Plant Sciences
Ioanna Efthimiou, Dimitris Vlastos, Vassilios Triantafyllidis, Antonios Eleftherianos, Maria Antonopoulou
Summary: This study investigated the genotoxic and cytotoxic activity of Betula pendula leaf extract and found that it exhibited antigenotoxic potential. The mixture of the extract with mitomycin-C showed significant antigenotoxic activity at low concentrations.
Article
Chemistry, Multidisciplinary
Danielle Mulder, Cornelius Johannes Francois Taute, Mari van Wyk, Pieter J. Pretorius
Summary: The study found that functionalized GNPs caused genotoxicity in HepG2 cells, but the cells were able to initiate repair mechanisms and recover DNA damage, except for two functionalization chemistries.
Article
Fisheries
Samantha Fernandes, Savita Kerkar, Avelyno D'Costa, Moreska Costa, Abhishek Mishra, Soorambail K. Shyama, Kirti Ranjan Das
Summary: The probiotic consortium SFSK4 used as a water additive during shrimp culture significantly increased shrimp immunity and decreased mortality by more than 50% against pathogens. Toxicology studies showed no adverse effects on shrimp survival or DNA damage. This suggests that SFSK4 is an eco-friendly alternative to antibiotics for enhancing shrimp immunity in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Plant Sciences
Debora Elisa Antunes de Mendonca, Mariane Aparecida Franco de Godoy, Naiara Cristina Lucredi, Jurandir Fernando Comar, Igor Vivian Almeida, Veronica Elisa Pimenta Vicentini
Summary: This study evaluated the effects of Ganoderma lucidum fruiting body dry extract (GLE) on human liver and kidney tumor cells as well as peripheral blood lymphocytes. The results showed that low concentrations of GLE increased lymphocyte viability while high concentrations were toxic to lymphocytes. On the other hand, low concentrations of GLE exhibited cytotoxic activity and induced DNA damage in tumor cells. Therefore, G. lucidum has potential antitumor effects and could be developed into a therapeutic agent for cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gamze Tan, Atakan Tevlek, Halil Murat Aydin
Summary: This study investigates the antioxidative and anticancer activities of gold nanoparticles (AuNPs) reduced by Allium cepa L. (onion-O) and Allium sativum L. (garlic-G) extracts. The results show that these particles have cytotoxic effects on different cancer cells and can modulate cell proliferation, apoptosis, and migration. Furthermore, AuNPs synthesized with onion extract exhibit stronger antioxidant activity compared to those synthesized with garlic extract.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Milos Ognjanovic, Zeljko Jacimovic, Milica Kosovic-Perutovic, Irina Besu Zizak, Tatjana Stanojkovic, Zeljko Zizak, Biljana Dojcinovic, Dalibor M. Stankovic, Bratislav Antic
Summary: Partial cation substitution can change the physical properties of compounds, and in this study, yttrium-substituted iron oxide nanoconstructs (YIONs) were prepared. The Y3+ substitution in maghemite (γ-Fe2O3) crystal structures was limited to 1.5%. The YIONs showed excellent heating efficiency and low toxicity, making them suitable for potential medical and technological applications such as magnetic hyperthermia cancer treatment and catalysis.
Article
Environmental Sciences
Luiza Flavia Veiga Francisco, Debora da Silva Baldivia, Bruno do Amaral Crispim, Syla Maria Farias Ferraz Klafke, Pamella Fukuda de Castilho, Lucilene Finoto Viana, Edson Lucas dos Santos, Kelly Mari Pires de Oliveira, Alexeia Barufatti
Summary: The study found that high concentrations of aluminum and manganese exhibit cytotoxic and genotoxic effects on cell lines, but do not show a clear mutagenic response.
Article
Pharmacology & Pharmacy
Raffaella di Vito, Mattia Acito, Cristina Fatigoni, Carl H. Schiesser, Michael J. Davies, Francesca Mangiavacchi, Milena Villarini, Claudio Santi, Massimo Moretti
Summary: This study evaluated the cytotoxic and genotoxic potential of SeTal in liver cells through in vitro experiments. The results showed that SeTal had minimal impact on cell viability and did not cause clastogenic or aneugenic activity. These findings suggest that SeTal may be a potential active pharmaceutical ingredient.
Article
Environmental Sciences
Fatma Turna Demir
Summary: This study investigates the genotoxicity and enhanced generation of reactive oxygen species (ROS) caused by bulk and nano forms of Hydroxyapatite (HAp), and tests the potential mitigation of DNA damage by resveratrol. The results demonstrate that both bulk and nano HAp induce DNA damage and ROS generation in Drosophila melanogaster, which can be alleviated by treatment with resveratrol.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Biochemistry & Molecular Biology
Terezia Zajickova, Eva Horvathova, Stanislav Kyzek, Eva Salyova, Eva Turyova, Andrea Sevcovicova, Eliska Galova
Summary: This study suggests that skyrin, a potential precursor of hypericin, has DNA-protective effects and shows promising potential in anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Toshihiro Nohara, Yukio Fujiwara, Mona El-Aasr, Tsuyoshi Ikeda, Masateru Ono, Daisuke Nakano, Junei Kinjo
Summary: This paper reviewed the examination and characterization of sulfides in garlic, onion, and Welsh onion extracts, identified new sulfide structures, proposed hypothetical pathways for sulfide production, and demonstrated the antitumor effects of onionin A(1) on tumor proliferation and metastasis through activation of the antitumor immune system. These findings suggest that onionin A(1) could be an effective adjuvant therapy for osteosarcoma, ovarian cancer, and other malignant tumors.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Arthur B. Ribeiro, Saulo D. Ozelin, Lucas H. D. da Silva, Francisco Rinaldi-Neto, Karoline S. Freitas, Heloiza D. Nicolella, Larissa D. R. de Souza, Ricardo A. Furtado, Wilson Roberto Cunha, Denise C. Tavares
Summary: Asiatic acid (AA) demonstrated antiproliferative activity in tumor cells, inducing DNA damage leading to cell cycle arrest and apoptosis, and also exhibited antioxidant effects.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Environmental Sciences
Jefferson Hollanda Veras, Camila Regina Do Vale, Elisa Flavia Luiz Cardoso Bailao, Murilo Machado Dos Anjos, Clever Gomes Cardoso, Matheus Gabriel de Oliveira, Jose Realino de Paula, Guilherme Roberto de Oliveira, Carolina Ribeiro E. Silva, Lee Chen-Chen
Summary: A coumarin-chalcone hybrid, 4-MET, was synthesized and evaluated for its genotoxic, cytotoxic, and protective effects. The results demonstrated that 4-MET showed chemopreventive potential and significantly reduced the harmful effects of certain mutagens, exhibiting a chemoprotective effect against DNA damage.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Toxicology
Serpil Konen Adiguzel
Summary: The use of pesticides in farmland has increased to protect crops, but their impact on non-target organisms cannot be ignored. A study on the herbicide Indaziflam revealed that it did not have a cytotoxic effect on cells, but it did induce DNA strand breaks and micronucleus formation.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Julia Poyato-Bonilla, Nora Laseca, Sebastian Demyda-Peyras, Antonio Molina, Mercedes Valera
Summary: The Carthusian horse, a Pura Raza Espanol strain, has been bred as a closed population for over 500 years. Analysis of its population structure revealed a unique genetic profile with a history of both differentiation and introgression. The study also noted recent reductions in variability and a genetic bottleneck in the population.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
Jose Maria Jimenez, Rosa Morales, Antonio Molina, Miguel Moreno-Millan, Sebastian Demyda-Peyras
Summary: This study analyzed the impact of rob(1;29) in the Retinta cattle breed and found that cows carrying the heterozygote genotype showed a significant decrease in fertility. After avoiding selection of carrier individuals as breeding bulls for 30 years, the breed's fertility significantly improved and the effect of rob(1;29) on cattle fertility was only significant when the prevalence of carriers was high.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Engineering, Chemical
Marcos Mateo-Fernandez, Miguel Josue Gonzalez-Jimenez, Mercedes Del Rio Celestino, Rafel Font, Angeles Alonso-Moraga, Tania Merinas-Amo
Summary: This study evaluated the toxicity of three artificial sweeteners, acesulfame-k, aspartame, and cyclamate. The results demonstrated that these compounds were not toxic or genotoxic in fruit flies, but they decreased the lifespan of the flies. Additionally, aspartame and cyclamate showed protective effects against genotoxins in fruit flies. In cell experiments, acesulfame-k and aspartame exhibited cytotoxicity and the ability to cause DNA damage.
Article
Engineering, Chemical
Tania Merinas-Amo, Mercedes Del Rio Celestino, Rafael Font, Angeles Alonso-Moraga
Summary: There is a growing interest in improving health to achieve better quality of life. Diet plays a crucial role in determining health conditions. In this study, the biological activities of three types of alcohol-free lager beer and one of their most abundant phenols, epicatechin gallate (ECG), were analyzed to identify their potential as nutraceuticals. The study employed Drosophila melanogaster as an animal model and human leukaemia cells (HL-60) for in vitro experiments. The results indicate the safety and protective properties of the tested compounds, with alcohol-free beers and ECG showing promising effects in terms of genotoxic activity, oxidative damage protection, longevity increase, and inhibition of tumour cell growth.
Article
Veterinary Sciences
Nora Laseca, Antonio Molina, Manuel Ramon, Mercedes Valera, Florencia Azcona, Ana Encina, Sebastian Demyda-Peyras
Summary: The study evaluated the impact of increased inbreeding levels on mare fertility, showing a negative correlation between whole-genome homozygosity and fertility estimated breeding values. The analysis also revealed chromosome-level variability and stronger correlations in a reduced dataset of the 10% most and least fertile individuals. Furthermore, the study identified genomic regions associated with fertility, including candidate genes related to oocyte and embryo development.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
N. Laseca, S. Demyda-Peyras, M. Valera, M. Ramon, B. Escribano, D. I. Perdomo-Gonzalez, A. Molina
Summary: This study conducted a genome-wide association study in horses to identify genomic variants, regions, and candidate genes associated with mare fertility. The results showed potential associations between reproductive efficiency and specific genetic markers, regions, and candidate genes, providing important insights into the genetic mechanisms of mare fertility.
Article
Chemistry, Analytical
Maria del Carmen Garcia-Garcia, Emilio Martin-Exposito, Isabel Font, Barbara del Carmen Martinez-Garcia, Juan A. Fernandez, Juan Luis Valenzuela, Pedro Gomez, Mercedes Del Rio-Celestino
Summary: This study explores the use of near-infrared reflectance spectroscopy (NIRS), a non-chemical and rapid technique, to determine the physicochemical quality of Pisum sativum L. ssp. arvense. The results show that NIRS has the potential for quantitative prediction and screening purposes.
Article
Agriculture, Dairy & Animal Science
Nora Laseca, Antonio Molina, Mercedes Valera, Alicia Antonini, Sebastian Demyda-Peyras
Summary: This study provides a detailed characterization of CNV regions in the Pura Raza Espanola horse breed, revealing a unique pattern of genomic regions enriched in CNVs and the incidence of CNVs across the entire genome. The study also identifies genes related to olfactory pathways and immune response. The findings contribute to our understanding of CNVs in equines and their impact on genetic and phenotypic variations.
Article
Agriculture, Dairy & Animal Science
Antonio Granero, Gabriel Anaya, Sebastian Demyda-Peyras, Maria J. Alcalde, Francisco Arrebola, Antonio Molina
Summary: This study used a genomic approach to investigate the genetic basis of historical Spanish Merino sheep, and found significant genetic differences between them and modern Merino breeds. They also exhibited high variability and richness in terms of genetics, suggesting that they should be protected as a valuable genetic population for improving sheep breeds.
Editorial Material
Chemistry, Analytical
Mercedes del Rio Celestino, Rafael Font
Article
Agriculture, Dairy & Animal Science
Ayelen Karlau, Antonio Molina, Alicia Antonini, Sebastian Demyda-Peyras
Summary: This study aimed to determine the genetic influence of foreign individuals on the reproductive performance of Argentine Criollo mares. The results showed that although foreign Criollo bloodlines had a certain impact on the fertility traits of Argentine Criollo mares, the use of foreign lineages did not significantly change their fertility.
Article
Agriculture, Dairy & Animal Science
Sebastian Demyda-Peyras, Nora Laseca, Gabriel Anaya, Barbara Kij-Mitka, Antonio Molina, Ayelen Karlau, Mercedes Valera
Summary: Chromosomal abnormalities are commonly associated with fertility impairments in horses. This study aimed to analyze the prevalence of chromosomal diseases in a large population of Pura Raza Espanol horses using a two-step molecular tool. Thirteen individuals showed positive results for chromosomal abnormalities, including cases of sex development disorders, blood chimerism, Turner syndrome, Klinefelter syndrome, and complex karyotypes. The overall prevalence in the entire population was about 0.05%, with sex development disorders and blood chimerism occurring at rates of 0.02% and 0.016%, respectively.
Article
Agriculture, Dairy & Animal Science
Jose Maria Jimenez, Rosa Maria Morales, Alberto Menendez-Buxadera, Sebastian Demyda-Peyras, Nora Laseca, Antonio Molina
Summary: This study analyzed fertility in beef production systems using reproductive efficiency and found that the random regression model can be recommended to improve fertility. The study also identified genetic markers and candidate genes associated with fertility in cattle.
Article
Agriculture, Dairy & Animal Science
Tatiana E. Ziegler, Antonio Molina, Manuel Ramon, Manuel Sanchez, Eva Munoz-Mejias, Alicia Antonini, Sebastian Demyda-Peyras
Summary: The genomic landscape of inbreeding was analyzed in Florida goats using runs of homozygosity (ROH) patterns as a tool to understand phenotypic differences. Inbreeding levels were determined for each individual using ROH-based inbreeding coefficients (F-ROH), and two groups were formed based on these levels. The distribution of ROH was analyzed in each group, showing differences in abundance and distribution among chromosomes. Genomic regions with increased ROH were identified, and candidate genes related to production, fertility, and heat resistance were found within these regions.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Letter
Biotechnology & Applied Microbiology
Timothy P. L. Smith, Derek M. Bickhart, Didier Boichard, Amanda J. Chamberlain, Appolinaire Djikeng, Yu Jiang, Wai Y. Low, Hubert Pausch, Sebastian Demyda-Peyras, James Prendergast, Robert D. Schnabel, Benjamin D. Rosen
Summary: The Bovine Pangenome Consortium (BPC) aims to assemble cattle genomes to create a comprehensive representation of cattle genomic diversity. Their goal is to provide genome assemblies and a community-approved pangenome reference as a public resource to replace breed-specific reference genomes. The BPC invites partners to participate in this collaborative effort and contribute to the development of this community-driven resource. It will serve as a foundation for cattle genomic selection and enable comparison across studies.
