Review
Immunology
Xin Ma, Chenhao Zhao, Yuyao Xu, Haifang Zhang
Summary: This mini-review focuses on the role and mechanism of host SUMOylation in the pathogenesis of six important clinical bacterial pathogens, providing new insights into the unique pathogen-host interaction based on host SUMOylation.
INFECTION AND IMMUNITY
(2023)
Review
Immunology
Muhammad Nadeem Abbas, Saima Kausar, Bibi Asma, Wenhao Ran, Jingui Li, Zini Lin, Tiejun Li, Hongjuan Cui
Summary: The interaction between bacteria and insects has widespread implications due to their global distribution. It can directly impact human health as insects serve as disease vectors, and also have economic consequences. Moreover, it is linked to high mortality rates in economically important insects, resulting in significant economic losses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Zohreh Riahi Rad, Zahra Riahi Rad, Hossein Goudarzi, Mehdi Goudarzi, Mohammad Mahmoudi, Javad Yasbolaghi Sharahi, Ali Hashemi
Summary: miRNAs play a critical role in gene expression regulation, affecting biological or pathological processes by targeting specific mRNAs. Bacterial pathogens suppress host miRNA expression for their own benefit, while miRNAs have been extensively studied in the interaction between host and bacterial pathogens.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Aryashree Arunima, Erin J. van Schaik, James E. Samuel
Summary: Long non-coding RNAs (lncRNAs) are conserved non-coding regulatory transcripts that play a role in various biological processes. They regulate chromatin function and mRNA stability and translation. Increasing evidence suggests that lncRNAs are involved in immune responses, microbiome development, and diseases such as neurological disorders, cancer, and infections. This review discusses the regulatory roles of lncRNAs in immune responses, host-microbe interactions, and bacterial infections. The study of lncRNAs is important for the development of alternative therapies for severe infections and the diagnosis and prognosis of human diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Vera Vozandychova, Pavla Stojkova, Kamil Hercik, Pavel Rehulka, Jiri Stulik
Summary: Ubiquitination, similar to phosphorylation and acetylation, plays a crucial role in regulating various cell processes. Understanding how pathogens manipulate host ubiquitination processes is important for vaccine development and disease treatment. Pathogenic bacteria encode effector proteins targeting the host ubiquitin machinery to disrupt host defense processes.
Editorial Material
Microbiology
Lanxiang Wang, Moxian Chen, Pui-Ying Lam, Francisco Dini-Andreote, Lei Dai, Zhong Wei
Summary: This comprehensive review discusses the multiple roles of flavonoids in mediating plant-microbe interactions, including their synthesis, transport, and exudation in plants, the importance of flavonoids in regulating plant-microbe interactions, and how flavonoids influence the overall community assembly of plant-root microbiomes. The review also highlights potential knowledge gaps in understanding how flavonoids determine the interactions between plants and commensal microbes, advocating for further research in this area for innovative strategies to manipulate plant-microbiome composition.
Article
Multidisciplinary Sciences
Ori Heyman, Dror Yehezkel, Camilla Ciolli Mattioli, Neta Blumberger, Gili Rosenberg, Aryeh Solomon, Dotan Hoffman, Noa Bossel Ben-Moshe, Roi Avraham
Summary: Encounters between host cells and intracellular bacterial pathogens lead to complex phenotypes that determine the outcome of infection. Single-cell RNA sequencing (scRNA-seq) has limited capacity to analyze the role of bacterial factors. The scPAIR-seq method developed in this study enables functional analysis of mutant-dependent changes in host transcriptomes, providing insights into bacterial virulence strategies and their interplay with host defense strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Gulab Chand Arya, Hagai Cohen
Summary: This article explores the multifaceted roles of fungal cutinases during the four major stages of infection, including spore attachment, germination, and penetration of host plants. Based on previous evidence and a molecular phylogenetic tree, the relationship between fungal species lifestyle and the activity of its cutinases is discussed.
Review
Cell Biology
Yanqing Bao, Lin Wang, Jianjun Sun
Summary: EsxA is crucial for the virulence of pathogenic mycobacteria by mediating mycobacterial escape from the phagosome and translocation to the cytosol. It also regulates host immune responses and interacts with multiple cellular proteins to stimulate various signal pathways.
Article
Fisheries
Siwei Wu, Linghe Kong, Bingxi Li, Xiao Tu, Zheng Guo, Jianmin Ye
Summary: The study successfully cloned OnCD152 from Nile tilapia and found its important role in immune response. Upon stimulation by bacterial pathogens, CD152 was significantly upregulated in the head kidney and spleen, and its binding ability with CD80/86 increased with concentration.
Review
Immunology
Rachel A. Cheng, Martin Wiedmann
Summary: Salmonella enterica is a diverse pathogen with over 2600 serovars, utilizing fimbriae as important organelles for interaction with hosts. Recent genome sequencing has uncovered novel fimbriae, shedding light on their diversity and distribution. Understanding Salmonella chaperone-usher fimbriome evolution and complexities in host-pathogen interactions is crucial for future research.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Sobiepanek, Lukasz Kuryk, Mariangela Garofalo, Sandeep Kumar, Joanna Baran, Paulina Musolf, Frank Siebenhaar, Joachim Wilhelm Fluhr, Tomasz Kobiela, Roberto Plasenzotti, Karl Kuchler, Monika Staniszewska
Summary: Mast cells play important roles in immune responses, including defense against antigens, modulation of inflammation, and immune responses to microorganisms. Controlling mast cell activation or stabilization is crucial for tissue homeostasis and pathogen clearance. Additionally, mast cells contribute to maintaining the balance between host and resident microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Suborno Jati, Soham Sengupta, Malini Sen
Summary: The study found that the Wnt5A signaling pathway plays different roles in handling pathogenic and non-pathogenic infections, with a potentially crucial role in regulating intracellular actin organization of bacteria.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Pavla Stojkova, Petra Spidlova
Summary: HU protein, a member of the nucleoid-associated protein family, plays a crucial role in regulating bacterial virulence, pathogenesis, and survival. Recent studies suggest that HU protein may not only exist inside bacteria but also be secreted outside bacteria and even enter host cells. However, its specific role in host cells is still not well understood and further research is needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Dominik Brokatzky, Serge Mostowy
Summary: Pyroptosis is a regulated form of cell death characterized by cell lysis and the release of pro-inflammatory molecules. It plays a crucial role in bacterial infection by promoting an inflammatory response and eliminating intracellular pathogens. Recent studies using various bacterial pathogens have enhanced our understanding of pyroptosis and its importance in host defense.
DISEASE MODELS & MECHANISMS
(2022)
Article
Biochemistry & Molecular Biology
Cristina Sorino, Valeria Catena, Tiziana Bruno, Francesca De Nicola, Stefano Scalera, Gianluca Bossi, Francesca Fabretti, Miguel Mano, Enrico De Smaele, Maurizio Fanciulli, Simona Iezzi
NUCLEIC ACIDS RESEARCH
(2020)
Article
Microbiology
Nina Wallaschek, Saskia Reuter, Sabrina Silkenat, Katharina Wolf, Carolin Niklas, Oezge Kayisoglu, Carmen Aguilar, Armin Wiegering, Christoph-Thomas Germer, Stefan Kircher, Andreas Rosenwald, Claire Shannon-Lowe, Sina Bartfeld
Summary: The study reveals that EBV infection in gastric cancer is associated with partial changes in the Ephrin receptor A2 (EPHA2) of gastric epithelial cells. In healthy gastric epithelium, this receptor is confined to cell-cell junctions, making it difficult for EBV infection, while it is expressed normally in cancer cells, making them susceptible to infection.
Article
Multidisciplinary Sciences
Carmen Aguilar, Susana Costa, Claire Maudet, R. P. Vivek-Ananth, Sara Zaldivar-Lopez, Juan J. Garrido, Areejit Samal, Miguel Mano, Ana Eulalio
Summary: Cells infected with Salmonella Typhimurium activate the ER-stress response in both infected and bystander cells, leading to JNK pathway activation, downregulation of transcription factor E2F1, and reprogramming of microRNA expression. This response is specific to Salmonella and is mediated by the host factor HMGB1, contributing to increased infection efficiency in bystander cells.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Clivia Lisowski, Jane Dias, Susana Costa, Ricardo Jorge Silva, Miguel Mano, Ana Eulalio
Summary: Research indicates that during Salmonella infection, dysregulation of host cell endolysosomal trafficking leads to inhibition of vacuolar replication in host cells arrested in G(1), while cytosolic replication of the closely related pathogen Shigella remains unaffected. This disruption results in Salmonella release into the host cytosol, compromising vacuole maturation and integrity.
Review
Biochemistry & Molecular Biology
Carmen Aguilar, Marta Alves da Silva, Margarida Saraiva, Mastura Neyazi, I. Anna S. Olsson, Sina Bartfeld
Summary: Infectious diseases remain a major threat globally, with antimicrobial resistance and emerging pathogens posing challenges. Utilizing organoid cultures for infectious disease research allows for personalized treatment approaches, by mimicking cellular structures and molecular mechanisms of organs, and providing insights into individual responses to infections and therapies. Organoids have the potential to advance the understanding of infection progression and host-specific factors influencing disease outcomes.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Immunology
Joao Paulo Silva Nunes, Pauline Andrieux, Pauline Brochet, Rafael Ribeiro Almeida, Eduardo Kitano, Andre Kenji Honda, Leo Kei Iwai, Debora Andrade-Silva, David Goudenege, Karla Deysiree Alcantara Silva, Raquel de Souza Vieira, Debora Levy, Sergio Paulo Bydlowski, Frederic Gallardo, Magali Torres, Edimar Alcides Bocchi, Miguel Mano, Ronaldo Honorato Barros Santos, Fernando Bacal, Pablo Pomerantzeff, Francisco Rafael Martins Laurindo, Priscila Camillo Teixeira, Helder I. Nakaya, Jorge Kalil, Vincent Procaccio, Christophe Chevillard, Edecio Cunha-Neto
Summary: Infection by Trypanosoma cruzi can lead to Chagas disease cardiomyopathy (CCC) characterized by arrhythmia, heart failure, and death. IFN-gamma and TNF-alpha are implicated in the mitochondrial dysfunction observed in CCC patients. Treatment with AMPK, NRF2, and SIRT1 agonists may ameliorate the progression of Chagas disease cardiomyopathy by protecting mitochondrial function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mar Cordero, Julia Garcia-Fernandez, Ivan C. Acosta, Ana Yepes, Jose Avendano-Ortiz, Clivia Lisowski, Babett Oesterreicht, Knut Ohlsen, Eduardo Lopez-Collazo, Konrad U. Foerstner, Ana Eulalio, Daniel Lopez
Summary: The induction of natural competence in Staphylococcus aureus occurs in response to ROS and host defenses during infection. Bacteria cope with reduced respiration by increasing the rate of glycolysis and obtaining energy through fermentation. Natural competence provides S. aureus with additional nutritional and metabolic possibilities, fostering genetic variability and allowing it to proliferate during infection.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Carmen Aguilar, Mindaugas Pauzuolis, Malvika Pompaiah, Ehsan Vafadarnejad, Panagiota Arampatzi, Mara Fischer, Dominik Narres, Mastura Neyazi, Ozge Kayisoglu, Thomas Sell, Nils Bluethgen, Markus Morkel, Armin Wiegering, Christoph-Thomas Germer, Stefan Kircher, Andreas Rosenwald, Antoine-Emmanuel Saliba, Sina Bartfeld
Summary: In this study, it was found that Helicobacter pylori prefers to attach to differentiated cells in the pit region of gastric units. Organoid models were used to validate this phenomenon, and it was discovered that differentiated pit cells with high levels of GKN1, GKN2 and PSCA were more susceptible to H. pylori attachment and CagA translocation. It was also found that attachment was unrelated to the expression of MUC5AC or PSCA, but relied on bacterial chemotaxis towards host cell-released urea, which was proportional to the size of the host cell.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio
Summary: miR-182-3p is identified as a post-transcriptional regulator of TRF2 and induces DNA damage and apoptosis by reducing TRF2 levels. Treatment with LNPs containing miR-182-3p can inhibit tumor growth in TNBC models and cross the blood-brain barrier for treating brain metastatic lesions.
EMBO MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ines Rodrigues Lopes, Laura Maria Alcantara, Ricardo Jorge Silva, Jerome Josse, Elena Pedrero Vega, Ana Marina Cabrerizo, Melanie Bonhomme, Daniel Lopez, Frederic Laurent, Francois Vandenesch, Miguel Mano, Ana Eulalio
Summary: This study investigates the interaction of 191 clinical isolates of Staphylococcus aureus with host cells, revealing the prevalence of intracellular replication and persistence. The study highlights the impact of phenotypic variation on infection characteristics and suggests potential implications for the treatment of staphylococcal infections.
NATURE COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Juber Herrera-Uribe, Sara Zaldivar-Lopez, Carmen Aguilar, Carmen Entrenas-Garcia, Rocio Bautista, M. Gonzalo Claros, Juan J. Garrido
Summary: This study identified differentially expressed miRNAs in the ileum of S. Typhimurium-infected pigs using small RNA sequencing, and found that miR-194a-5p regulates the expression of the TLR4 gene, which is important in pathogen virulence, recognition, and activation of innate immunity in Salmonella infection.
VETERINARY RESEARCH
(2022)
